Teneligliptin and Metformin Hydrochloride Uses in Diabetes

Introduction

TENELIGOLD M 1000, manufactured by Steris Healthcare, is a fixed-dose oral antidiabetic medication containing Teneligliptin 20 mg and Metformin Hydrochloride 1000 mg (Extended Release). It is prescribed for patients with Type 2 Diabetes Mellitus (T2DM) who do not achieve adequate glycemic control with diet, lifestyle modifications, or monotherapy. Teneligliptin is a potent DPP-4 inhibitor, and Metformin is a first-line biguanide antidiabetic agent. The combination works through complementary mechanisms—improving insulin secretion and reducing hepatic glucose production—to provide efficient and sustained blood sugar control. TENELIGOLD M 1000 is widely accepted for its balance of efficacy, safety, and patient compliance.The teneligliptin and metformin hydrochloride uses include reducing fasting and postprandial blood glucose levels, improving insulin sensitivity, and delaying disease progression.

Chemical Composition and Formulations

TENELIGOLD M 1000 contains:

• Teneligliptin 20 mg

• Metformin Hydrochloride 1000 mg (Extended Release)

Formulated as an oral tablet, it is intended for adult patients. The extended-release version of Metformin minimizes gastrointestinal discomfort and supports sustained glucose control.

Mechanism of Action

Teneligliptin inhibits the enzyme DPP-4, which leads to increased levels of incretin hormones like GLP-1 and GIP. These hormones enhance glucose-dependent insulin secretion and suppress glucagon release.Metformin reduces hepatic glucose production, improves peripheral insulin sensitivity, and enhances glucose uptake. This dual mechanism addresses both fasting and postprandial hyperglycemia without significant risk of hypoglycemia.

Uses and Indications

The key teneligliptin and metformin hydrochloride uses include:

• Management of Type 2 Diabetes Mellitus in adults who have not achieved adequate glycemic control with Metformin alone or other antidiabetic agents.

• Recommended for patients with insulin resistance or elevated HbA1c despite lifestyle changes.

• Considered beneficial in overweight or obese patients where weight neutrality is desired.

Not indicated for:

• Type 1 Diabetes

• Diabetic ketoacidosis

Dosage and Administration

• Recommended dose: One tablet daily with the largest meal to reduce gastrointestinal side effects.

• Tablets must be swallowed whole with water; do not crush or chew.

• If a dose is missed, it should be taken as soon as remembered unless it’s near the time for the next dose.

Dosage adjustments may be required based on renal function and clinical response.

Efficacy and Clinical Evidence

Clinical trials and real-world studies have demonstrated:

• Reduction in HbA1c by 0.8–1.5%

• Improved postprandial and fasting glucose levels

• High tolerability and low incidence of hypoglycemia

• Enhanced patient adherence due to once-daily dosing

Comparative studies also show better tolerability and cost-effectiveness versus sulfonylureas or insulin in early-stage T2DM.

Side Effects and Safety Profile

Common side effects:

• Gastrointestinal discomfort (nausea, diarrhea, flatulence)

• Headache

• Dizziness

• Abdominal pain

• Loss of appetite

• Upper respiratory tract infection

• Constipation

• Weight gain

• Sweating

• Vision impairment

Rare or serious effects:

• Lactic acidosis (linked to Metformin, particularly in renal impairment)

• Pancreatitis (rare with Teneligliptin)

• Vitamin B12 deficiency with long-term use

Side effects are generally mild and often resolve with continued use or dietary adjustments.

Contraindications and Precautions

Contraindications:

• Known hypersensitivity to Teneligliptin or Metformin

• Severe renal or hepatic impairment

• History of lactic acidosis

• Alcohol dependence

Precautions:

• Use with caution in elderly patients

• Not recommended during pregnancy or lactation without medical guidance

• Monitor renal function regularly

• Discontinue temporarily before contrast imaging procedures

Drug Interactions

Potential interactions include:

• Alcohol: Increases risk of lactic acidosis

• Iodinated contrast agents: Can compromise renal function

• Corticosteroids, thiazide diuretics, and beta-blockers: May alter glycemic response

• Other antidiabetic agents: Combined use may require monitoring for hypoglycemia

Always disclose all concurrent medications, including herbal and OTC supplements, to your healthcare provider.

Warnings and Regulatory Status

• Approved by the Drug Controller General of India (DCGI) for management of Type 2 Diabetes.

• Metformin carries a lactic acidosis warning, especially in patients with renal dysfunction.

• No black box warning on Teneligliptin.

• Should be used strictly under a physician’s supervision.

Patient Advice and Tips

• Maintain a balanced diabetic-friendly diet and engage in regular physical activity.

• Take the medication after food to minimize stomach upset.

• Store in a cool, dry place away from direct sunlight.

• Do not self-adjust dosage; consult your doctor for any modifications.

• Monitor blood glucose regularly and maintain follow-up appointments.

Recent Developments and Research

• Studies are investigating the combination's effects on cardiorenal protection.

• Ongoing trials are evaluating its utility in combination with SGLT2 inhibitors.

• Research also suggests favorable outcomes in newly diagnosed diabetics where dual therapy is initiated early.

Frequently Asked Questions (FAQs)

1.What are teneligliptin and metformin hydrochloride uses?
They are used together to manage Type 2 Diabetes Mellitus by improving insulin sensitivity and stimulating insulin release.

2.How should I take TENELIGOLD M 1000?
Take one tablet daily after food, preferably the largest meal of the day, unless directed otherwise by your doctor.

3.Is this medicine safe for long-term use?
Yes, with regular medical monitoring, it is considered safe for long-term diabetes control.

4.Can it cause hypoglycemia?
Rarely. Hypoglycemia is more common when combined with sulfonylureas or insulin.

5.Is this combination safe in pregnancy?
It is not recommended during pregnancy unless explicitly prescribed by a physician.

6.Where can I buy TENELIGOLD M 1000?
You can purchase it from licensed pharmacies or online at https://sterisonline.com.

7.What should I do if I miss a dose?
Take the missed dose as soon as possible. Skip it if it’s close to your next dose. Do not double-dose.

8.Can I drink alcohol while taking this medicine?
Avoid alcohol as it increases the risk of lactic acidosis, particularly with Metformin.

Conclusion

The combination of Teneligliptin and Metformin Hydrochloride, as seen in TENELIGOLD M 1000, offers a clinically sound, effective, and well-tolerated option for managing Type 2 Diabetes Mellitus. Its dual action targets multiple metabolic abnormalities while reducing the risk of hypoglycemia.Importantly, the teneligliptin and metformin hydrochloride uses make this combination an effective solution for those requiring dual therapy for optimal glycemic control.For individuals seeking comprehensive glycemic control with convenience and affordability, TENELIGOLD M 1000 is a trusted choice under proper medical guidance.

Why Choose Steris Healthcare Pvt Ltd for TENELIGOLD M 1000

Steris Healthcare Pvt Ltd stands out as a trusted name in the pharmaceutical industry. Here's why it's the preferred choice for TENELIGOLD M 1000:

• Trusted Quality: Manufactured under WHO-GMP certified facilities.

• Patient-Focused: Designed to improve real-world outcomes.

• Locally Optimized: Tailored for Indian patients' needs.

• Wide Reach: Available across India through a strong distribution network.

• Cost-Effective: Premium quality without the high price.

Choosing Steris Healthcare Pvt Ltd ensures reliability, affordability, and clinically sound diabetes care.