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Tmozolmide 100

Temozolomide (100mg)

Tmozolmide 100 is a potent chemotherapeutic medication containing Temozolomide100mg, an oral alkylating agent used in the treatment of specific types of brain cancer, such as glioblastoma multiforme and anaplastic astrocytoma. As a standard of care in oncology, Tmozolmide 100 is recognized for its effectiveness in penetrating the blood-brain barrier, making it a crucial tool in combating aggressive brain tumors.

Composition

• Active Ingredient: Temozolomide (100mg)
• Excipients: Lactose anhydrous, sodium starch glycolate, tartaric acid, stearic acid, and other inactive ingredients that ensure the stability and efficacy of the capsule.

Mechanism of Action

Temozolomide is a prodrug that undergoes rapid conversion in the body to its active form, MTIC (methyl-triazeno-imidazole-carboxamide). MTIC works by methylating the DNA of cancer cells at the O6 and N7 positions of guanine residues, leading to DNA damage and triggering cell cycle arrest and apoptosis. This mechanism is particularly effective against rapidly dividing cancer cells.

Indications

Tmozolmide 100 is indicated for:

• Newly Diagnosed Glioblastoma Multiforme: Used in conjunction with radiotherapy followed by maintenance treatment.
• Refractory Anaplastic Astrocytoma: Indicated for patients whose disease has progressed despite previous therapy.
• Off-Label Uses: Occasionally used for other malignancies, such as metastatic melanoma and certain sarcomas, under the guidance of an oncologist.

Dosage and Administration

• Standard Dosage: For newly diagnosed glioblastoma, the initial dose is 75mg/m² daily for 42 days alongside radiotherapy, followed by maintenance dosing of 150-200mg/m² once daily for 5 days in a 28-day cycle.
• Administration: Tmozolmide 100 should be taken on an empty stomach to enhance absorption, preferably at the same time each day.
• Dose Adjustments: Dosage may be adjusted based on patient response and tolerability, with close monitoring for hematologic and non-hematologic toxicities.

Benefits

• Penetrates Blood-Brain Barrier: One of the few chemotherapeutic agents that can effectively cross the blood-brain barrier, providing direct treatment to brain tumors.
• Proven Efficacy: Demonstrated to improve overall survival and progression-free survival in patients with glioblastoma.
• Convenient Oral Administration: Easier for patients to take compared to intravenous chemotherapeutic agents, enhancing compliance and quality of life.

Side Effects

While Tmozolmide 100 is effective, it can cause several side effects, including:

• Hematologic Toxicity: Myelosuppression, including neutropenia, thrombocytopenia, and anemia, is common and requires regular blood monitoring.
• Gastrointestinal Issues: Nausea, vomiting, and loss of appetite are frequent but can often be managed with supportive care.
• Fatigue: Many patients experience significant fatigue during treatment.
• Liver Toxicity: Potential for elevated liver enzymes, necessitating periodic liver function tests.
• Increased Infection Risk: Due to immunosuppression, patients are more susceptible to infections and should take precautions to avoid exposure to pathogens.

Precautions and Warnings

• Regular Monitoring: Patients should undergo regular blood tests to monitor blood cell counts and liver function.
• Contraindications: Not recommended for patients with severe bone marrow suppression or known hypersensitivity to Temozolomide.
• Drug Interactions: Caution is advised when used with other myelosuppressive agents or medications that can increase the risk of liver toxicity.
• Pregnancy and Nursing: Temozolomide is teratogenic and should not be used during pregnancy. Women of childbearing potential should use effective contraception, and breastfeeding is contraindicated during treatment.

Conclusion

Tmozolmide 100, with its active ingredient Temozolomide, plays a critical role in the management of aggressive brain tumors such as glioblastoma multiforme and anaplastic astrocytoma. Its ability to cross the blood-brain barrier and directly target cancer cells within the central nervous system makes it an invaluable treatment option in oncology. Despite the potential for significant side effects, the benefits of improved survival and tumor control make Tmozolmide 100 a cornerstone in the treatment of malignant brain tumors. With careful monitoring and adherence to prescribed guidelines, patients can achieve optimal outcomes in their fight against these challenging cancers.Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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