Trelagliptin 50 mg: Dose, Uses, Side Effects & Why TRELAQWK 50 is a Smart Choice

Jun 05, 2025

Introduction

TRELAQWK 50 is a once-weekly oral antidiabetic formulation containing Trelagliptin 50 mg, developed to improve glycemic control in adults with type 2 diabetes mellitus. Trelagliptin belongs to the class of DPP-4 inhibitors (Dipeptidyl Peptidase-4 inhibitors), known for their ability to regulate insulin and glucose levels effectively.This product is part of a new generation of diabetes medications that provide the convenience of weekly dosing, supporting better adherence and improved blood sugar control.

Composition

Each film-coated tablet of TRELAQWK 50 contains:

  • Active Ingredient: Trelagliptin Succinate equivalent to Trelagliptin 50 mg

  • Dosage Form: Oral tablet

  • Administration Route: Oral

  • Packaging: Blister pack for extended shelf life

What is Trelagliptin?

Trelagliptin is a long-acting DPP-4 inhibitor designed to reduce blood sugar levels by:

  • Enhancing insulin secretion post meals

  • Decreasing glucagon secretion

  • Improving the function of pancreatic beta cells

Unlike other DPP-4 inhibitors that require daily intake, Trelagliptin 50 mg allows once-weekly administration, increasing patient compliance and convenience.

Trelagliptin Tablet Uses

Trelagliptin tablets, especially in the 50 mg strength, are used for:

  • Type 2 Diabetes Management: As monotherapy or in combination with other antidiabetic drugs (e.g., metformin, sulfonylureas, or insulin)

  • Blood Sugar Control: Lowers fasting and postprandial glucose levels

Note: It is not suitable for type 1 diabetes or for treating diabetic ketoacidosis.

Trelagliptin Dose

Standard Dosage

  • Trelagliptin Dose: 50 mg once weekly

  • Taken orally with or without food

Dosing Guidelines

  • Administer on the same day each week

  • Do not double dose if a dose is missed

  • Dose adjustments may be required in renal or hepatic impairment

TRELAQWK 50 is ideal for early-stage type 2 diabetes or patients who require a lower dose due to mild comorbidities.

How TRELAQWK 50 Works

Trelagliptin 50 mg inhibits the DPP-4 enzyme, which breaks down incretin hormones (GLP-1 and GIP). These incretins:

  • Increase insulin secretion in a glucose-dependent manner

  • Reduce glucagon secretion

  • Help in overall glycemic control

The weekly dosing offers a significant advantage in patient lifestyle and medication adherence compared to daily oral antidiabetics.

Trelagliptin Side Effects

Trelagliptin is generally well tolerated. However, like all medications, it may cause some side effects.

Common Side Effects

  • Headache

  • Nasopharyngitis (cold-like symptoms)

  • Upper respiratory tract infection

  • Gastrointestinal discomfort

Less Common but Serious Side Effects

  • Hypoglycemia (especially when combined with insulin or sulfonylureas)

  • Allergic skin reactions

  • Pancreatitis (rare)

  • Liver enzyme elevation

Precautions

  • Use with caution in patients with kidney or liver issues

  • Not recommended during pregnancy or lactation without medical advice

Advantages of Trelagliptin 50 mg (TRELAQWK 50)

  • Once-weekly dose enhances patient compliance

  • Low risk of hypoglycemia when used alone

  • Suitable for combination therapy

  • Better control of both fasting and postprandial glucose

  • Convenient alternative to daily DPP-4 inhibitors

Contraindications

Do not use TRELAQWK 50 in patients with:

  • Type 1 diabetes mellitus

  • Diabetic ketoacidosis

  • History of hypersensitivity to Trelagliptin or excipients

Drug Interactions

Trelagliptin may interact with:

  • Other antidiabetics (e.g., insulin, sulfonylureas)

  • Renally excreted drugs

  • Drugs affecting liver metabolism (consult a physician)

TRELAQWK 50 – Product Summary

Feature Details
Brand Name TRELAQWK 50
Generic Name Trelagliptin 50 mg
Drug Class DPP-4 Inhibitor
Indication Type 2 Diabetes Mellitus
Dosage 50 mg once weekly
Route of Administration Oral
Manufacturer Steris Healthcare Pvt. Ltd.

FAQs – Trelagliptin 50 mg (TRELAQWK 50)

Q1. What is Trelagliptin 50 mg used for?

Trelagliptin 50 mg is used for the management of type 2 diabetes mellitus to help regulate blood sugar levels in adult patients.

Q2. How often should I take TRELAQWK 50?

The recommended Trelagliptin dose is 50 mg once a week. Take it on the same day each week for consistent control.

Q3. What are the side effects of Trelagliptin tablets?

Common trelagliptin side effects include headache, cold-like symptoms, and indigestion. Serious but rare effects include pancreatitis and allergic reactions.

Q4. Can Trelagliptin 50 mg be taken with metformin?

Yes, Trelagliptin tablets can be safely combined with metformin and other oral antidiabetic drugs under medical supervision.

Q5. Is TRELAQWK 50 available online?

Yes, you can buy TRELAQWK 50 online from Sterisonline, the trusted e-commerce portal of Steris Healthcare.

Q6. Is Trelagliptin better than Sitagliptin?

Both are effective DPP-4 inhibitors, but Trelagliptin offers once-weekly dosing, making it more convenient than Sitagliptin, which is taken daily.

Conclusion

TRELAQWK 50, formulated with Trelagliptin 50 mg, offers a modern solution for managing type 2 diabetes with once-weekly dosing convenience. With good tolerability, reduced pill burden, and proven clinical efficacy, it represents a breakthrough in DPP-4 inhibitor therapy. Always use under medical supervision and combine with lifestyle changes for best results.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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