trigliclaglaze 60

Introduction

TRIGLICLAGLAZE 60 is a combination medication that contains Gliclazide 60mg (SR), Pioglitazone 15mg, and Metformin Hydrochloride 500mg (SR). It is prescribed for the management of type 2 diabetes mellitus (T2DM) in patients who require multiple mechanisms of action to achieve better glycemic control. This powerful anti-diabetic formulation helps regulate blood sugar levels by addressing insulin resistance, insulin secretion, and glucose production.

Key Ingredients and Their Mechanism of Action

1. Gliclazide 60mg (Sustained Release - SR)

• Class: Sulfonylurea

• Mechanism of Action: Gliclazide stimulates the pancreatic beta cells to secrete more insulin, thereby reducing blood sugar levels. It also has antioxidant and vascular protective properties, making it beneficial in diabetes-related complications.

2. Pioglitazone 15mg

• Class: Thiazolidinedione (TZD)

• Mechanism of Action: Pioglitazone improves insulin sensitivity by acting on peripheral tissues (muscle and fat). It increases glucose uptake and decreases hepatic glucose production, leading to better glycemic control.

3. Metformin HCL 500mg (Sustained Release - SR)

• Class: Biguanide

• Mechanism of Action: Metformin works by reducing glucose production in the liver and improving insulin sensitivity in muscles. It also helps lower the absorption of glucose from the intestine.

Uses of TRIGLICLAGLAZE 60

1. Management of Type 2 Diabetes Mellitus (T2DM)

2. Improvement of Insulin Sensitivity

3. Reduction of HbA1c Levels

4. Prevention of Diabetes-Related Complications such as neuropathy, nephropathy, and retinopathy

5. Weight Management Benefits, particularly in insulin-resistant patients

6. Cardiovascular Benefits (due to pioglitazone’s effect on lipid profiles)

Dosage and Administration

• Standard Dosage: One tablet once or twice daily, as directed by a healthcare professional.

• Timing: Preferably taken with meals to reduce gastrointestinal side effects.

• Titration: The dosage may be adjusted based on blood sugar levels and patient tolerance.

Benefits of TRIGLICLAGLAZE 60

•  Comprehensive Glycemic Control: Targets multiple pathways to manage diabetes effectively.
•  Sustained Release (SR) Formulation: Ensures longer action and better compliance.
  •  Improves Beta Cell Function:  helps protect pancreatic beta cells from oxidative stress.
•  Enhances Insulin Sensitivity: Pioglitazone reduces insulin resistance in muscle and fat tissues.
•  Reduces Hepatic Glucose Output: Metformin controls excess sugar production from the liver.
•  Weight Neutral or Slight Loss: Due to Metformin’s effects on reducing fat accumulation.
•  Cardiovascular and Anti-Inflammatory Benefits: Pioglitazone has been linked to improved lipid profiles and reduced inflammation.

Side Effects of TRIGLICLAGLAZE 60

Like any medication, TRIGLICLAGLAZE 60 may cause some side effects, which vary from person to person. Some of the common and rare side effects include:

Common Side Effects:

• Mild Hypoglycemia (low blood sugar levels)

• Nausea and Vomiting

• Diarrhea or Constipation

• Flatulence (Gas Formation)

• Weight Gain (due to Gliclazide and Pioglitazone)

• Mild Fluid Retention (Edema)

Serious but Rare Side Effects:

• Lactic Acidosis (associated with Metformin overdose)

• Liver Dysfunction (monitor liver enzymes regularly)

• Severe Hypoglycemia (requires immediate glucose intake)

• Cardiac Issues (Pioglitazone may cause fluid retention, leading to heart failure in rare cases)

• Bladder Cancer Risk (long-term use of Pioglitazone may slightly increase risk, though controversial)

Precautions and Warnings

• Not for Type 1 Diabetes or Diabetic Ketoacidosis.

• Kidney and Liver Impairment: Regular monitoring of kidney (eGFR) and liver function is recommended.

• Cardiac Patients: Pioglitazone should be used cautiously in patients with heart failure.

• Pregnancy & Lactation: Consult a doctor before use.

• Alcohol Consumption: Should be limited or avoided, as it may increase the risk of hypoglycemia and lactic acidosis.

Drug Interactions

• Beta-Blockers: May mask symptoms of hypoglycemia.

• Diuretics & NSAIDs: Increase the risk of fluid retention and heart failure with Pioglitazone.

• Antibiotics (Rifampin): May reduce Pioglitazone levels.

• Corticosteroids: Can increase blood glucose levels.

• ACE Inhibitors: May enhance the blood sugar-lowering effect.

Lifestyle and Dietary Recommendations

•  Follow a Balanced Diet: Include high-fiber foods, lean proteins, and healthy fats.
•  Engage in Regular Exercise: At least 30 minutes of moderate activity daily.
•  Monitor Blood Sugar Levels: Regularly check fasting and postprandial glucose.
•  Stay Hydrated: Helps reduce the risk of metformin-induced lactic acidosis.
•  Avoid Sugary and Processed Foods: Prevents sudden blood sugar spikes.

Comparison with Other Antidiabetic Combinations

Conclusion

TRIGLICLAGLAZE 60 is a powerful combination therapy for type 2 diabetes, offering an effective triple-action approach through Gliclazide (insulin secretion), Pioglitazone (insulin sensitivity), and Metformin (glucose reduction). It is suitable for patients who require an intensified treatment regimen to achieve their blood sugar targets. However, regular monitoring, lifestyle modifications, and adherence to medical guidance are essential for the best results. If you experience any adverse effects, consult a healthcare provider promptly for appropriate intervention.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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