UDCHOLIC SR 450 : Ursodeoxycholic Acid (450 mg)

Introduction

UDCHOLIC SR 450 is a pharmaceutical formulation containing Ursodeoxycholic Acid (450 mg), primarily used for treating liver-related conditions and improving bile flow. This sustained-release (SR) tablet ensures gradual release, maximizing therapeutic benefits. Let’s explore its comprehensive details, from uses and benefits to precautions and possible side effects.The liver is a vital organ that plays a critical role in detoxification, metabolism, and digestion. However, liver conditions such as cholestasis, bile acid imbalance, and gallstones can impair its functioning. UDCHOLIC SR 450, with Ursodeoxycholic Acid (450 mg) as the active ingredient, is a proven medication that enhances bile flow, protects liver cells, and alleviates liver-related complications. Its sustained-release formulation ensures consistent therapeutic action.

Key Ingredients

Ursodeoxycholic Acid (450 mg)

• Ursodeoxycholic Acid (UDCA) is a naturally occurring bile acid.
• It has hepatoprotective properties that reduce liver cell damage caused by bile acid accumulation.
• Helps dissolve cholesterol-based gallstones and improves bile flow in conditions like primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).

Key Benefits

1. Improves Liver Function

• UDCHOLIC SR 450 promotes bile secretion, which prevents toxic bile acid buildup.
• It enhances liver detoxification and protects hepatocytes from damage.

2. Dissolves Gallstones

• This medication helps dissolve cholesterol gallstones, reducing the need for surgical intervention in specific cases.

3. Relieves Cholestasis Symptoms

• Cholestasis occurs when bile flow from the liver is impaired. UDCHOLIC SR 450 helps restore bile flow and reduces itching and fatigue associated with the condition.

4. Manages Primary Biliary Cholangitis (PBC)

• It is commonly used to treat PBC, a chronic autoimmune disease affecting bile ducts, reducing liver inflammation and damage.

5. Supports Non-Alcoholic Fatty Liver Disease (NAFLD)

• Ursodeoxycholic Acid (450 mg) may improve liver enzyme levels and reduce fat accumulation in the liver.

6. Prevents Liver Damage in Cystic Fibrosis

• Patients with cystic fibrosis often experience liver complications. This medication supports liver function by improving bile flow.

How Does It Work?

Mechanism of Action

• Ursodeoxycholic Acid (450 mg) works by reducing the toxicity of bile acids that accumulate in liver cells during bile flow obstruction.
• It replaces toxic bile acids with non-toxic forms, thereby preventing liver cell damage.
• Additionally, it helps dissolve cholesterol from gallstones by decreasing cholesterol secretion into bile.

Sustained-Release Advantage

• The sustained-release (SR) formulation allows for the gradual release of Ursodeoxycholic Acid, maintaining a steady concentration in the bloodstream. This enhances efficacy and minimizes fluctuations in therapeutic effects.

Uses of UDCHOLIC SR 450

1. Primary Biliary Cholangitis (PBC):

   • Helps in the long-term management of autoimmune bile duct damage.

2. Gallstone Dissolution:

   • Useful in patients with cholesterol gallstones who are unsuitable for surgery.

3. Cholestatic Liver Diseases:

   • Treats bile flow obstruction and associated liver damage.

4. Non-Alcoholic Fatty Liver Disease (NAFLD):

   • Assists in reducing liver fat accumulation and improving enzyme profiles.

5. Cystic Fibrosis-Related Liver Disease:

   • Prevents liver complications by supporting bile flow.

6. Pregnancy-Related Cholestasis:

   • Used under medical supervision to manage symptoms like itching and bile flow issues.

Dosage and Administration

Recommended Dosage

• The usual dosage is one UDCHOLIC SR 450 tablet daily, or as prescribed by a healthcare professional.

Administration Tips

• Take the tablet with water, preferably with meals to enhance absorption.
• Follow the prescribed schedule and avoid missing doses for optimal results.
• Do not crush or chew the tablet, as it is designed for sustained release.

Missed Dose

• If a dose is missed, take it as soon as possible. If it’s close to the next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

• In case of an overdose, seek immediate medical attention. Symptoms may include diarrhea, nausea, and abdominal discomfort.

Side Effects

Common Side Effects

1. Diarrhea: Mild and transient in nature.
2. Nausea: Especially in the initial days of treatment.
3. Abdominal Pain: Linked to improved bile flow.

Rare but Serious Side Effects

1. Allergic Reactions: Skin rashes, itching, or swelling.
2. Liver Enzyme Alterations: Regular monitoring of liver function is essential.
3. Severe Diarrhea: May require dose adjustment.

If you experience any unusual symptoms, consult your doctor immediately.

Precautions

Before Using UDCHOLIC SR 450

1. Allergy Check: Inform your doctor if you’re allergic to Ursodeoxycholic Acid or any inactive ingredient.
2. Medical History: Share details about conditions like liver cirrhosis, gallstones, or bile duct blockages.
3. Pregnancy and Breastfeeding: Use under medical supervision if you are pregnant or breastfeeding.

During Treatment

1. Regular Monitoring: Liver function tests are necessary to track the medication’s effectiveness.
2. Avoid Alcohol: Alcohol may worsen liver conditions and reduce the effectiveness of the medication.
3. Maintain Hydration: Drink plenty of water to prevent dehydration, especially if diarrhea occurs.

Interactions with Other Medications

1. Cholestyramine or Colestipol:

   • May reduce the absorption of Ursodeoxycholic Acid. Take these at least 2 hours apart.

2. Antacids Containing Aluminum:

   • Decrease the effectiveness of UDCHOLIC SR 450. Avoid concurrent use.

3. Estrogen or Oral Contraceptives:

   • May increase bile cholesterol, reducing the medication’s gallstone-dissolving effects.

4. Ciclosporin:

   • Dosage adjustments may be necessary due to altered absorption.

Inform your healthcare provider about all medications, supplements, and herbal remedies you’re taking.

Who Should Avoid UDCHOLIC SR 450?

1. Patients with Non-Functional Gallbladder:
   • The medication is ineffective in such cases.
2. Severe Liver Disease:
   • Contraindicated in advanced liver conditions.
3. Acute Infections:
   • Not suitable during acute bile duct infections.

Price and Availability

UDCHOLIC SR 450 is widely available in pharmacies. The cost in India typically ranges between ₹400 and ₹600 for a strip of 10 tablets, though prices may vary based on location and pharmacy.

Storage Instructions

• Store the tablets at room temperature (15–25°C) in a cool, dry place.
• Keep them away from direct sunlight and moisture.
• Ensure they are out of reach of children.

Conclusion

UDCHOLIC SR 450 is a reliable medication for managing liver-related disorders and bile acid imbalances. Its active ingredient, Ursodeoxycholic Acid (450 mg), has a proven track record of improving liver health, dissolving gallstones, and alleviating cholestasis symptoms. With its sustained-release formulation, this medication ensures consistent efficacy, making it a vital choice for patients with chronic liver conditions. Always use UDCHOLIC SR 450 under the supervision of a healthcare provider to maximize its benefits while minimizing potential risks. Regular monitoring, adherence to dosage, and lifestyle adjustments can further enhance the therapeutic outcomes. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline  ,  Sterisindia and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

For further information 

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