Understanding Trimetazidine 80mg: Uses, Dosage, and Side Effects

Introduction

Trimetazidine (80 mg), marketed as TRIMETAZ CR 80, is a modified-release formulation used as an adjunct treatment in stable angina pectoris. It works by improving the efficiency of the heart’s energy metabolism, thus enhancing cardiac function without affecting hemodynamics.

Composition

• Active Ingredient: Trimetazidine Dihydrochloride 80 mg (Modified Release)

Indications and Uses

TRIMETAZ CR 80 is primarily indicated for:

• Chronic Stable Angina Pectoris: Used as an add-on therapy in patients inadequately controlled by or intolerant to first-line anti-anginal agents (e.g., beta-blockers or calcium channel blockers).

• Cardiac Ischemia Support: Helps protect myocardial cells against ischemia without altering blood pressure or heart rate.

Mechanism of Action

Trimetazidine acts at the cellular level to maintain energy metabolism in cardiac cells under hypoxic conditions. It inhibits long-chain 3-ketoacyl-CoA thiolase (LC 3-KAT), a key enzyme in fatty acid oxidation, thereby shifting metabolism toward glucose oxidation. This shift helps preserve ATP levels, enhances myocardial glucose utilization, and improves overall cardiac function.

Recommended Dosage

• Adults: One tablet of TRIMETAZ CR 80 once daily, preferably with food.

• Elderly Patients and Renal Impairment: Dose adjustment may be necessary. Assessment of renal function is recommended before and during treatment.

Note: This medication is not suitable for use in acute angina attacks or as an initial therapy for unstable angina or myocardial infarction.

Side Effects of Trimetazidine

While Trimetazidine is generally well-tolerated, some patients may experience the following side effects:

Common Side Effects:

• Headache

• Dizziness

• Abdominal pain

• Nausea and vomiting

• Diarrhea

Rare but Serious Side Effects:

• Gait disorders (especially in elderly patients)

• Extrapyramidal symptoms (tremor, rigidity, instability)

• Allergic skin reactions such as rash or pruritus

Patients with Parkinson’s disease or Parkinsonian symptoms should avoid this medication, as it may worsen these conditions.

Warnings and Precautions

• Parkinson’s Disease: Contraindicated due to risk of motor symptom exacerbation.

• Renal Impairment: Dose adjustments required; monitor renal function regularly.

• Driving and Machinery Use: Trimetazidine may cause dizziness or drowsiness; use caution.

Drug Interactions

No significant drug interactions have been reported with Trimetazidine; however, it's best to inform your healthcare provider of all medications you are currently using.

Storage Instructions

• Store below 25°C.

• Protect from moisture and direct sunlight.

• Keep out of reach of children.

Why Choose TRIMETAZ CR 80?

• Modified-release technology ensures steady plasma levels and once-daily dosing.

• Well-tolerated in long-term use.

• Ideal as an add-on in angina management when standard therapies are insufficient.

Frequently Asked Questions (FAQs)

Q. Can TRIMETAZ CR 80 be taken with other heart medications?
Yes, it is commonly prescribed alongside beta-blockers, nitrates, or calcium channel blockers for better angina control.

Q. How long should I take Trimetazidine 80 mg?
Your doctor will determine the duration based on your condition. It is typically used for long-term management.

Q. Is it safe to stop TRIMETAZ CR 80 suddenly?
Consult your physician before stopping any medication, especially for chronic cardiac conditions.

Conclusion

TRIMETAZ CR 80 (Trimetazidine 80 mg MR Tablet) is a clinically trusted solution for the long-term management of chronic stable angina. With its once-daily modified-release formulation, it enhances myocardial efficiency without affecting hemodynamic parameters—making it a valuable add-on therapy in cardiac care. Backed by quality manufacturing and patient-centric design, TRIMETAZ CR 80 stands out as a safe, effective, and convenient choice for heart health.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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