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Vildiabate M 500

Metformin (500mg)SR, Vildagliptin (50mg)

Vildiabate M 500 is a combination oral antidiabetic medication containing Vildagliptin and Metformin. This combination is specifically designed to improve glycemic control in adults with Type 2 diabetes mellitus. Vildagliptin is a DPP-4 inhibitor that enhances insulin secretion and reduces glucagon levels, while Metformin is a biguanide that decreases hepatic glucose production and improves insulin sensitivity. Together, they provide a comprehensive approach to managing blood glucose levels.

Composition

• Active Ingredients:
  • Vildagliptin (50mg)
  • Metformin Hydrochloride (500mg)
• Excipients: Microcrystalline cellulose, povidone, magnesium stearate, hypromellose, and other inactive ingredients that ensure the stability and efficacy of the tablet.

Mechanism of Action

Vildiabate M 500 works through the combined mechanisms of its two active ingredients:

• Vildagliptin: Inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), increasing the levels of active incretin hormones (GLP-1 and GIP). These hormones enhance insulin secretion and suppress glucagon release, helping to lower blood glucose levels, particularly after meals.
• Metformin: Decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. This results in lower blood glucose levels, both fasting and postprandial.

Indications

Vildiabate M 500 is indicated for:

• Type 2 Diabetes Mellitus: Used to improve glycemic control in adults with Type 2 diabetes, particularly when diet and exercise alone do not provide adequate control. It can be used as monotherapy or in combination with other antidiabetic agents.

Dosage and Administration

• Standard Dosage: The typical dose is one tablet taken twice daily with meals to reduce gastrointestinal side effects. The dosage may be adjusted based on the patient’s needs and the prescribing physician’s advice.
• Administration: Vildiabate M 500 should be taken with food to minimize gastrointestinal discomfort. Tablets should be swallowed whole with water.
• Dose Adjustments: Adjustments may be necessary based on the patient's renal function and response to treatment. Regular monitoring of blood glucose levels is essential to ensure optimal dosing.

Benefits

• Improved Glycemic Control: The combination of Vildagliptin and Metformin offers superior glycemic control compared to monotherapy.
• Convenient Dosing: Combines two effective antidiabetic agents into a single tablet, simplifying the treatment regimen and enhancing patient compliance.
• Reduced Risk of Hypoglycemia: Vildagliptin has a lower risk of causing hypoglycemia compared to some other antidiabetic medications.
• Weight Neutral or Weight Loss: Metformin is often associated with weight loss or at least weight neutrality, which is beneficial for overweight or obese patients with Type 2 diabetes.

Side Effects

While Vildiabate M 500 is generally well-tolerated, it may cause some side effects, including:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and abdominal discomfort are common, particularly during the initial phase of treatment.
• Headache: Some patients may experience headaches.
• Dizziness: Mild dizziness can occur but usually diminishes over time.
• Nasopharyngitis: Inflammation of the nasal passages and throat is a common side effect.
• Rare but Serious Side Effects: Lactic acidosis (a rare but serious complication of Metformin) and pancreatitis may occur. Immediate medical attention is required if these symptoms develop.

Precautions and Warnings

• Renal Function Monitoring: Patients with renal impairment should have their kidney function regularly monitored, and dose adjustments may be necessary.
• Liver Function Tests: Liver enzymes should be checked before starting treatment and periodically thereafter, as Vildagliptin can cause liver enzyme elevations.
• Contraindications: Not recommended for patients with a history of severe hypersensitivity to Vildagliptin, Metformin, or any of their components. Also contraindicated in patients with severe renal impairment, metabolic acidosis, or a history of lactic acidosis.
• Pregnancy and Nursing: The safety of Vildiabate M 500 during pregnancy and breastfeeding has not been established. It should only be used if the potential benefits justify the potential risks.

Drug Interactions

• Other Antidiabetic Agents: When used in combination with other antidiabetic medications, there may be an increased risk of hypoglycemia.
• ACE Inhibitors: Concurrent use may increase the risk of angioedema.
• Corticosteroids: These may reduce the blood glucose-lowering effect of Vildagliptin and Metformin.
• Diuretics: Can increase the risk of lactic acidosis when taken with Metformin.

Conclusion

Vildiabate M 500, containing both Vildagliptin and Metformin, provides a comprehensive and effective approach to managing Type 2 diabetes mellitus. Its dual mechanism of action helps to regulate blood glucose levels, improve glycemic control, and reduce the risk of diabetes-related complications. With benefits such as improved glycemic control, convenient dosing, and a lower risk of hypoglycemia, Vildiabate M 500 is a valuable addition to diabetes management. Regular monitoring and adherence to prescribed guidelines are crucial for maximizing the therapeutic benefits and minimizing potential side effects. Vildiabate M 500 remains a cornerstone in the treatment of Type 2 diabetes, helping patients achieve better health outcomes and improved quality of life.Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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