BEMPIDOC EZ 180/10

BEMPIDOC EZ 180/10 is a powerful lipid-lowering combination therapy formulated with Bempedoic Acid and Ezetimibe, designed to effectively control elevated cholesterol levels in patients who need additional LDL-C (bad cholesterol) reduction. This dual-action medication is particularly beneficial for individuals with primary hyperlipidemia, including heterozygous familial hypercholesterolemia (HeFH), a genetic disorder that causes dangerously high cholesterol. It is suitable for patients who are either intolerant to statins or require supplemental treatment alongside statins for optimized lipid control.

What is BEMPIDOC EZ 180/10?

BEMPIDOC EZ 180/10 is a prescription tablet that contains a fixed-dose combination of:

• Bempedoic Acid (180 mg) – an oral ATP-citrate lyase (ACL) inhibitor that works upstream in the cholesterol biosynthesis pathway.

• Ezetimibe (10 mg) – a cholesterol absorption inhibitor that prevents dietary and biliary cholesterol absorption in the intestine.

Together, these ingredients work synergistically to lower LDL-C levels more effectively than either agent alone.

Uses of BEMPIDOC EZ 180/10

This combination is used:

• To reduce bad cholesterol (LDL-C) in patients with primary hyperlipidemia, including those with heterozygous familial hypercholesterolemia (HeFH).

• As an adjunct to diet and lifestyle modifications.

• For patients inadequately controlled with statin therapy or who are statin-intolerant.

• In cases where monotherapy with either agent fails to achieve LDL-C goals.

Side Effects of Bempedoic Acid and Ezetimibe

While BEMPIDOC EZ 180/10 is generally well-tolerated, some individuals may experience side effects. Common and potential bempedoic acid and ezetimibe side effects include:

Bempedoic Acid Side Effects:

• Muscle spasms or pain

• Increased uric acid levels (hyperuricemia)

• Upper respiratory tract infections

• Back pain

• Elevated liver enzymes

Ezetimibe Side Effects:

• Headache

• Diarrhea

• Abdominal pain

• Fatigue

• Joint pain

• Allergic reactions (rash, swelling)

Seek immediate medical attention if serious symptoms such as severe muscle pain, signs of liver dysfunction (jaundice, dark urine), or allergic reactions occur.

Precautions Before Using

Before starting BEMPIDOC EZ 180/10, inform your healthcare provider if you:

• Have a history of gout or hyperuricemia

• Suffer from liver or kidney disorders

• Are pregnant or breastfeeding

• Are taking other lipid-lowering medications

• Have muscle-related conditions or experience unexplained muscle pain

Routine monitoring of liver enzymes, uric acid levels, and kidney function is recommended during treatment.

Drug Interactions

Several medications may interact with BEMPIDOC EZ 180/10, potentially altering its effects or increasing the risk of side effects.

What drugs interact with BEMPIDOC EZ 180/10?

• Statins (e.g., simvastatin, pravastatin) – Increased risk of muscle toxicity; dose adjustments may be needed.

• Fibrates (e.g., gemfibrozil) – May increase the risk of myopathy or rhabdomyolysis.

• Cyclosporine – Can raise the plasma concentration of ezetimibe.

• Colesevelam (bile acid sequestrants) – Should be administered several hours apart to prevent reduced absorption of ezetimibe.

• Anticoagulants (e.g., warfarin) – Monitor INR closely when initiating or discontinuing therapy.

Always consult your physician or pharmacist before starting or stopping any medication while on BEMPIDOC EZ 180/10.

Conclusion

BEMPIDOC EZ 180/10 offers a targeted and modern approach for individuals struggling with high LDL cholesterol despite statin therapy or those unable to tolerate statins. With the combined efficacy of bempedoic acid and ezetimibe, it helps achieve lipid goals and reduce cardiovascular risk in patients with primary hyperlipidemia, including HeFH. For best results, pair this treatment with a heart-healthy diet, exercise, and regular lipid monitoring.

If you're concerned about bempedoic acid and ezetimibe side effects or drug interactions, consult your healthcare provider for personalized advice.