GLIDAPAFLOZIN M 10/500

GLIDAPAFLOZIN M 10/500 is a scientifically formulated oral antidiabetic medication that combines two powerful agents: dapagliflozin and metformin hydrochloride extended-release. Designed to provide optimal glycemic control, this combination works through dual mechanisms—reducing glucose production in the liver and enhancing glucose excretion through urine. It is especially effective in adults with Type 2 Diabetes Mellitus (T2DM) who require improved blood sugar management along with lifestyle modifications like diet and exercise.

What is Dapagliflozin and Metformin Hydrochloride?

Dapagliflozin and Metformin Hydrochloride is a combination of two antidiabetic medicines:

• Dapagliflozin is a selective SGLT2 inhibitor that helps lower blood glucose by increasing urinary glucose excretion.

• Metformin Hydrochloride (Extended-Release) is a biguanide that reduces hepatic glucose production and enhances insulin sensitivity.

Together, these agents offer a synergistic effect to lower fasting and postprandial blood glucose levels without causing significant weight gain or hypoglycemia.

Uses of Dapagliflozin and Metformin Hydrochloride Tablets

GLIDAPAFLOZIN M 10/500 is prescribed for:

• Managing Type 2 Diabetes Mellitus in adults, especially when monotherapy is insufficient

• Reducing HbA1c levels in diabetic patients

• Supporting weight management in overweight individuals with diabetes

• Helping prevent cardiovascular complications in diabetic patients

• Offering dual glucose control through insulin-independent mechanisms

Side Effects of Dapagliflozin and Metformin

While GLIDAPAFLOZIN M 10/500 is generally well-tolerated, some patients may experience mild to moderate side effects such as:

• Genital infections (especially in women, due to increased glucose in urine)

• Urinary tract infections

• Increased urination

• Nausea, vomiting, or diarrhea (common with metformin)

• Abdominal discomfort

• Headache or fatigue

Rare but serious side effects may include:

• Lactic acidosis (a rare but life-threatening condition linked to metformin)

• Dehydration or low blood pressure due to excess urination

• Ketoacidosis, especially in insulin-deficient conditions

Always report persistent or severe symptoms to your healthcare provider immediately.

Precautions Before Using Dapagliflozin and Metformin

Before starting GLIDAPAFLOZIN M 10/500, consider the following:

• Not suitable for patients with Type 1 Diabetes or diabetic ketoacidosis

• Use with caution in patients with kidney or liver impairment

• Avoid alcohol as it increases the risk of lactic acidosis

• Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding

• Monitor blood sugar levels regularly to avoid unexpected hypoglycemia when used with other antidiabetics

• Stay well-hydrated to reduce the risk of dehydration

Drug Interactions: What Drugs Interact with Dapagliflozin and Metformin Hydrochloride?

Certain medications may influence the efficacy or safety of dapagliflozin and metformin hydrochloride, such as:

• Diuretics: May increase the risk of dehydration and low blood pressure

• Insulin or sulfonylureas: May enhance the risk of hypoglycemia

• Rifampicin, phenytoin, or phenobarbital: May reduce dapagliflozin levels

• Cimetidine: Can elevate metformin concentration, increasing lactic acidosis risk

• Contrast dyes (iodinated contrast): Can cause acute kidney injury, increasing metformin-related risks

• ACE inhibitors or ARBs: May alter kidney function and require dosage adjustment

Always provide your full medical history and list of current medications to your physician before starting this therapy.

Conclusion

GLIDAPAFLOZIN M 10/500 offers a modern, dual-acting solution for the effective control of Type 2 Diabetes. With the combined power of dapagliflozin and metformin hydrochloride extended-release, it addresses both insulin resistance and excess glucose levels—without burdening the patient with weight gain or frequent hypoglycemic episodes.

Ideal for those seeking comprehensive diabetic management, GLIDAPAFLOZIN M 10/500 empowers patients to regain control of their health and live a more balanced life.

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