GLISITAPTIN M 50/500

GLISITAPTIN M 50/500 is a combination oral anti-diabetic medicine formulated to manage Type 2 Diabetes Mellitus (T2DM) in adults. This combination includes sitagliptin phosphate 50 mg and metformin hydrochloride 500 mg, working together to improve blood glucose control when diet and exercise alone are insufficient.The product is manufactured with strict quality standards and offers a balanced therapeutic approach to glycemic control without causing significant weight gain or hypoglycemia when used as prescribed.

What is Sitagliptin Phosphate 50 mg and Metformin Hydrochloride 500 mg?

This fixed-dose combination includes:

• Sitagliptin Phosphate 50 mg: A DPP-4 (Dipeptidyl Peptidase-4) inhibitor that increases incretin levels, helping the body release insulin and lower glucagon levels in a glucose-dependent manner.

• Metformin Hydrochloride 500 mg: A biguanide class medication that reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues.

Together, they offer a dual mechanism of action that provides better glycemic control than either drug alone.

Uses of Sitagliptin Phosphate 50 mg and Metformin Hydrochloride 500 mg

GLISITAPTIN M 50/500 is used to:

• Manage Type 2 Diabetes Mellitus in adults

• Improve glycemic control in patients whose blood sugar levels are not adequately controlled by metformin alone

• Delay the progression of diabetes-related complications such as neuropathy, nephropathy, and retinopathy

• Enhance insulin sensitivity and reduce insulin resistance

This combination is not intended for use in Type 1 diabetes or diabetic ketoacidosis.

Side Effects of Sitagliptin Phosphate 50 mg and Metformin Hydrochloride 500 mg

Like all medications, GLISITAPTIN M 50/500 may cause side effects in some individuals:

Common Side Effects:

• Nausea and vomiting

• Diarrhea or stomach upset

• Headache

• Upper respiratory tract infection

• Metallic taste

Less Common but Serious Side Effects:

• Lactic acidosis (a rare but serious complication of metformin)

• Pancreatitis

• Low blood sugar (hypoglycemia), especially if used with sulfonylureas or insulin

• Allergic reactions (rash, swelling, itching)

If any severe side effects or allergic reactions occur, seek immediate medical attention.

Precautions Before Using

Before starting sitagliptin phosphate 50 mg and metformin hydrochloride 500 mg, inform your doctor if:

• You have kidney or liver impairment

• You consume alcohol regularly

• You have heart failure or recent heart attack

• You are scheduled for any surgery or radiological procedures involving contrast dye

• You are pregnant or breastfeeding

Avoid excessive alcohol consumption as it may increase the risk of lactic acidosis when combined with metformin.

Drug Interactions – What Drugs Interact with Sitagliptin Phosphate 50 mg and Metformin Hydrochloride 500 mg?

Inform your doctor if you're taking any of the following:

• Diuretics (e.g., furosemide) – may increase risk of dehydration and kidney issues

• Beta-blockers – may mask symptoms of hypoglycemia

• Corticosteroids – can raise blood sugar levels

• ACE inhibitors or ARBs – may alter kidney function when used with metformin

• Iodinated contrast agents – increase the risk of lactic acidosis during imaging procedures

• Other oral antidiabetics or insulin – increase the risk of low blood sugar

Always consult your physician before starting or stopping any medications.

Conclusion

GLISITAPTIN M 50/500, containing sitagliptin phosphate 50 mg and metformin hydrochloride 500 mg, is a clinically effective and well-tolerated treatment for managing Type 2 Diabetes Mellitus. Its dual action not only controls blood sugar but also supports better long-term metabolic outcomes when used consistently along with lifestyle changes.