INH IPRATROP DUO

Respiratory conditions like asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, and emphysema require effective bronchodilation therapy to relieve airway constriction and improve breathing.
Ipratropium Bromide 20 mg and Levosalbutamol 50 mcg Respirator Solution is a widely prescribed combination medication designed for inhalation via a nebulizer. It offers dual-action relief by relaxing airway muscles and reducing mucus secretion, making breathing easier for patients with obstructive lung diseases.

This guide provides a detailed understanding of the composition, uses, benefits, dosage, mechanism of action, side effects, safety precautions, and storage guidelines to help healthcare professionals and patients use it effectively.  

Composition

Each 2.5 ml unit dose of Ipratropium Bromide and Levosalbutamol Respirator Solution typically contains:

• Ipratropium Bromide IP – 20 mcg
  (Per actuation or equivalent nebulized dose)

• Levosalbutamol (Levalbuterol) IP – 50 mcg
  (As levosalbutamol hydrochloride)

• Sterile isotonic saline solution as the base 

Pharmacological Class

• Ipratropium Bromide: Anticholinergic (muscarinic antagonist) bronchodilator

• Levosalbutamol: Selective β₂-adrenergic receptor agonist bronchodilator

The combination works synergistically to relieve bronchospasm and improve airflow. 

Mechanism of Action

Ipratropium Bromide

• Blocks muscarinic cholinergic receptors in the bronchial smooth muscle

• Prevents acetylcholine-mediated bronchoconstriction

• Reduces mucus gland secretion in the airways

Levosalbutamol

• Stimulates β₂-adrenergic receptors in bronchial smooth muscle

• Increases cyclic AMP (cAMP), leading to smooth muscle relaxation

• Provides rapid bronchodilation and improved airflow

Combined Effect:

• Ipratropium Bromide addresses parasympathetic-mediated bronchoconstriction,

• Levosalbutamol targets sympathetic pathways to relax airway muscles.
  Together, they produce a faster and more sustained bronchodilatory effect than either drug alone.  

Therapeutic Indications

Ipratropium Bromide 20 mg and Levosalbutamol 50 mcg Respirator Solution is indicated for:

1. Chronic Obstructive Pulmonary Disease (COPD) – including chronic bronchitis and emphysema

2. Asthma – for acute or chronic management, especially when single bronchodilator therapy is insufficient

3. Exercise-Induced Bronchospasm

4. Post-infectious Bronchospasm

5. Airway Obstruction in Allergic Respiratory Disorders 

Key Benefits

1. Rapid Symptom Relief – Levosalbutamol acts within minutes to reduce airway tightness

2. Prolonged Bronchodilation – Ipratropium provides sustained effects for hours

3. Dual-Mechanism Approach – Addresses different bronchoconstriction pathways

4. Reduced Need for Multiple Inhalers – Convenient single solution for nebulization

5. Improved Lung Function – Increases forced expiratory volume (FEV₁)

6. Better Symptom Control – Especially for patients unresponsive to single-drug therapy 

Dosage & Administration

• Route: Inhalation via nebulizer only

• Adult Dose: One unit dose vial (usually 2.5 ml) every 6–8 hours, as prescribed

• Pediatric Dose: As directed by the physician, often lower depending on age/weight

• Instructions:

  1. Wash hands before handling.

  2. Open the unit-dose vial by twisting the top.

  3. Pour the solution into the nebulizer chamber.

  4. Use the nebulizer mask or mouthpiece and inhale deeply until the mist stops.

  5. Clean the nebulizer after each use.

Possible Side Effects

Like all medicines, this solution can cause some side effects, usually mild and temporary:

• Dry mouth or throat irritation

• Cough after inhalation

• Mild tremors or shakiness

• Headache

• Palpitations

• Nausea

• Rarely: allergic reactions like rash or swelling

If severe side effects occur—such as chest pain, irregular heartbeat, or difficulty breathing—stop use and seek medical help immediately.  

Precautions & Warnings

• Pregnancy & Breastfeeding: Use only if prescribed

• Cardiac Disorders: Monitor patients with arrhythmias or heart disease

• Glaucoma: Avoid eye contact to prevent worsening

• Urinary Retention: Use cautiously in prostate enlargement

• Allergic Reactions: Avoid use if allergic to any component

• Drug Interactions:

  • Other β₂-agonists may increase side effects

  • MAO inhibitors and tricyclic antidepressants may enhance cardiovascular effects

Buying Ipratropium Bromide 20 mg and Levosalbutamol 50 mcg Respirator Solution

When purchasing this medication, ensure it comes from a reputed and licensed pharmaceutical supplier.
Steris Healthcare ensures:

• WHO-GMP certified manufacturing

• Premium quality active ingredients

• Stringent quality control

• Competitive pricing

• Reliable nationwide distribution

Ipratropium Bromide 20 mg and Levosalbutamol 50 mcg Respirator Solution offers a powerful, dual-action bronchodilation therapy ideal for patients with asthma, COPD, and other obstructive lung diseases. With rapid onset, prolonged relief, and reduced side effects, it has become a trusted choice among healthcare professionals worldwide.

When sourced from Steris Healthcare, patients are assured of consistent quality, safety, and therapeutic efficacy—making it the preferred choice for better respiratory health.