MESALMILE 400 is a medication that contains Mesalamine ER (400mg) as its active ingredient. Mesalamine, also known as 5-aminosalicylic acid, is a potent anti-inflammatory agent primarily used to treat and manage inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. MESALMILE 400 is formulated as an extended-release (ER) tablet, which ensures a controlled and sustained release of the medication throughout the day, providing long-lasting relief from symptoms and promoting intestinal healing.

Key Benefits:

• Effective Symptom Relief: MESALMILE 400 helps in reducing symptoms of ulcerative colitis and Crohn's disease, such as abdominal pain, diarrhea, and rectal bleeding.
• Sustained Release: The extended-release formulation ensures that the medication is gradually released over time, providing consistent therapeutic effects and reducing the frequency of dosing.
• Promotes Intestinal Healing: By targeting inflammation directly in the colon, MESALMILE 400 aids in the healing of the intestinal lining, contributing to long-term disease management.
• Minimal Systemic Absorption: Mesalamine primarily acts locally within the colon, which minimizes systemic side effects and enhances its safety profile.

How Does It Work?

Mesalamine, the active ingredient in MESALMILE 400, is an anti-inflammatory agent that specifically targets the colon. It inhibits the production of inflammatory chemicals called prostaglandins and leukotrienes by blocking the enzyme cyclooxygenase and reducing the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). This action helps to decrease inflammation and promotes the healing of the colonic mucosa, thereby relieving the symptoms of inflammatory bowel diseases.

Directions for Use:

• Dosage: Follow the dosage instructions provided by your healthcare provider. Typically, MESALMILE 400 is taken once or twice daily.
• Administration: Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet as it is designed for extended release.
• Consistency: Take the medication at the same time(s) each day to maintain an even level of the drug in your system.
• Dietary Considerations: MESALMILE 400 can be taken with or without food. However, if you experience stomach upset, it is advisable to take it with food.

Side Effects:

While MESALMILE 400 is generally well-tolerated, some individuals may experience side effects. Common side effects include:

• Gastrointestinal Issues: Nausea, vomiting, abdominal pain, and diarrhea.
• Headache: Some users may experience headaches.
• Skin Reactions: Rash or itching in some individuals.
• Fatigue: A feeling of tiredness or weakness.

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