OB-COLLAR 10

OB-COLLAR 10 contains Obeticholic Acid 10 mg, a revolutionary treatment specifically designed for patients suffering from chronic liver conditions such as primary biliary cholangitis (PBC) and nonalcoholic fatty liver disease (NAFLD), including its advanced form nonalcoholic steatohepatitis (NASH). As liver diseases continue to rise globally due to metabolic disorders, OB-COLLAR 10 emerges as a targeted therapy that addresses bile acid regulation and inflammation at the cellular level. Manufactured with stringent quality standards, OB-COLLAR 10 by Steris Healthcare offers a reliable option for managing progressive liver diseases and improving overall hepatic function.

Obeticholic acid (OCA) is exemplified as a potent drug for treating primary biliary cirrhosis and nonalcoholic fatty liver disease by inhibiting bile acid synthesis.

What is Obeticholic Acid 10 mg (OB-COLLAR 10)?

Obeticholic Acid is a semi-synthetic bile acid analogue that works by activating the farnesoid X receptor (FXR) in the liver and intestine. FXR plays a vital role in regulating bile acid production, lipid metabolism, and inflammation. OB-COLLAR 10, by stimulating FXR, reduces the production of bile acids in the liver and increases bile flow, thus preventing liver damage caused by bile acid accumulation in conditions such as primary biliary cholangitis (PBC).

Uses of OB-COLLAR 10 (Obeticholic Acid 10 mg):

• Treatment of Primary Biliary Cholangitis (PBC) in adults, either as monotherapy or in combination with ursodeoxycholic acid (UDCA) when response to UDCA alone is inadequate.

• Under clinical evaluation and off-label use in managing Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) due to its role in reducing liver fibrosis and bile acid-related inflammation.

• Helps in improving liver enzyme levels, reducing hepatic inflammation, and slowing disease progression in chronic liver conditions.

Side Effects of OB-COLLAR 10:

While OB-COLLAR 10 is well-tolerated by many patients, some may experience mild to moderate side effects, including:

• Pruritus (itching) – the most common side effect, sometimes requiring dosage adjustment

• Fatigue

• Abdominal pain

• Rash or allergic reactions

• Elevated liver enzymes (transaminases) in some individuals

• Constipation or diarrhea

Serious liver-related adverse reactions may occur in rare cases, especially with inappropriate dosing in advanced cirrhosis. Always consult your doctor immediately if symptoms like jaundice, severe itching, or dark urine appear.

Precautions Before Using OB-COLLAR 10:

• Not recommended in patients with decompensated cirrhosis (Child-Pugh Class B or C) or a history of liver failure unless strictly supervised by a hepatologist.

• Regular liver function monitoring is necessary during therapy, especially in the initial months.

• Inform your physician if you have any gallbladder problems, biliary obstruction, or cardiovascular issues.

• Caution is advised in pregnant or breastfeeding women due to limited safety data.

• Dosage should be adjusted in patients with moderate to severe hepatic impairment.

Drug Interactions: What drugs interact with OB-COLLAR 10?

Certain medications can influence the efficacy or safety of Obeticholic Acid. Common drug interactions include:

• Bile acid sequestrants (e.g., cholestyramine, colesevelam): These can reduce the absorption of obeticholic acid. It's advised to take OB-COLLAR 10 at least 4–6 hours before or after these medications.

• Warfarin and other anticoagulants: Obeticholic acid may alter INR levels, requiring closer monitoring.

• CYP1A2 substrates (e.g., theophylline): Co-administration may increase levels of these drugs.

• Statins (e.g., simvastatin): Use with caution due to altered lipid metabolism.

Always share a complete list of your medications with your healthcare provider to avoid harmful interactions.

Conclusion

OB-COLLAR 10 is a scientifically advanced treatment option offering hope for patients suffering from chronic liver diseases like PBC and NAFLD. Its targeted action on bile acid synthesis and liver inflammation makes it a vital part of modern hepatology. As with all medications, it should be used under medical supervision with careful monitoring for maximum benefit and safety.