PERINDPRIM PLUS is a combined medication designed to effectively manage hypertension, leveraging the synergistic effects of Perindopril and Indapamide. This medication is prescribed to help control high blood pressure, reducing the risk of cardiovascular complications.

Active Ingredients:

1. Perindopril: This is an ACE (angiotensin-converting enzyme) inhibitor that works by relaxing blood vessels, allowing blood to flow more smoothly and lowering blood pressure. It helps in preventing heart attacks, strokes, and kidney problems.

2. Indapamide: A thiazide-like diuretic, Indapamide promotes the elimination of excess salt and water from the body through urine, thereby reducing fluid retention and lowering blood pressure.

Mechanism of Action:

• Perindopril: Inhibits the ACE enzyme, which normally causes blood vessels to constrict. By blocking this enzyme, Perindopril allows blood vessels to relax and widen, lowering blood pressure.

• Indapamide: Acts on the kidneys to increase urine production, reducing fluid retention and lowering blood volume, which in turn helps to lower blood pressure.

Indications:

PERINDPRIM PLUS is primarily indicated for the treatment of hypertension (high blood pressure) in adults. It is especially beneficial for patients who require a combination of an ACE inhibitor and a diuretic to achieve optimal blood pressure control.

Dosage and Administration:

• The dosage of PERINDPRIM PLUS should be determined by a healthcare provider based on individual patient factors such as age, medical history, and current medications.
• Typically, the medication is taken orally once daily, preferably in the morning, with or without food.
• It is important to adhere to the prescribed dosage and follow the healthcare provider’s instructions for maximum effectiveness.

Side Effects:

As with any medication, PERINDPRIM PLUS may cause side effects, although not everyone experiences them. Common side effects may include:

• Dizziness
• Headache
• Fatigue
• Cough
• Nausea
• Electrolyte imbalance (due to Indapamide’s diuretic effect)

Precautions:

• Patients with a history of allergic reactions to ACE inhibitors or sulfonamide-derived medications should avoid PERINDPRIM PLUS.
• Regular monitoring of blood pressure and electrolyte levels is recommended during treatment.
• It is important to inform healthcare providers about all medications being taken, as certain drugs may interact with PERINDPRIM PLUS.

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