Trimetazidine 60mg |TRIMETAZ CR 60
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Manufactured By Steris Healthcare Pvt Ltd
Composition Trimetazidine HCI Modified Release Tablets 60 mg
Rs 157.50
MRP Rs 225.00
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Description:
Trimetazidine 60mg is a prescription anti-anginal medicine used to manage chronic stable angina (chest pain caused by reduced blood flow to the heart) when other treatments alone aren't enough. Unlike beta-blockers or calcium channel blockers, it works by improving how the heart muscle uses energy under low-oxygen conditions, without significantly affecting heart rate or blood pressure. It is typically taken as one modified-release tablet twice daily with meals. Trimetazidine 60mg is a Schedule H prescription medicine and should only be used under medical supervision.
What Is Trimetazidine 60mg Used For?
Trimetazidine 60mg is prescribed as an add-on therapy for adults with chronic stable angina who are not adequately controlled by first-line anti-anginal medicines, or who cannot tolerate them. It is also sometimes used to support patients with ischemic heart disease where recurring chest discomfort affects daily life. It is not a rescue medicine for sudden chest pain and does not replace emergency treatments like sublingual nitroglycerin.
How Does Trimetazidine 60mg Work?
Trimetazidine works through a metabolic mechanism rather than a hemodynamic one. During reduced blood flow (ischemia), heart cells are forced to rely on fatty acid oxidation for energy, which is less oxygen-efficient. Trimetazidine partially inhibits this fatty acid pathway and shifts the heart's energy production toward glucose oxidation, which requires less oxygen per unit of ATP generated. This helps protect heart cells from ischemic stress, reduces the frequency of angina episodes, and improves exercise tolerance — all without lowering heart rate or blood pressure, which makes it a useful option for patients who cannot tolerate beta-blockers or calcium channel blockers.
Clinical Indications
| Condition | How Trimetazidine 60mg Helps |
|---|---|
| Chronic stable angina | Reduces frequency and severity of angina episodes as add-on therapy |
| Inadequate response to first-line anti-anginals | Used alongside beta-blockers/calcium channel blockers when symptoms persist |
| Intolerance to hemodynamic anti-anginals | Alternative option that doesn't affect heart rate or blood pressure |
| Exercise-induced chest discomfort | Improves exercise tolerance in stable angina patients |
Dosage Guidelines
| Parameter | Recommendation |
|---|---|
| Standard dose | 60mg per day, generally divided as per the modified-release formulation prescribed |
| Administration | Taken with meals, swallowed whole with water |
| Duration | Long-term use as advised by the cardiologist; not for acute attacks |
| Missed dose | Take as soon as remembered; skip if close to the next dose |
| Renal impairment | Dose adjustment required; consult physician |
Precautions
- Inform your doctor about kidney function, as dose adjustment may be needed in renal impairment.
- Not recommended in patients with Parkinson's disease, parkinsonian symptoms, tremors, restless legs syndrome, or other related movement disorders.
- Should be used cautiously in elderly patients due to increased risk of motor symptoms.
- Not a substitute for emergency angina treatment; keep prescribed rescue medication available.
- Inform your doctor of all other medicines, including over-the-counter drugs and supplements, before starting therapy.
- Pregnant or breastfeeding women should use only if clearly advised by a physician.
Drug Interactions
Trimetazidine has a relatively low interaction profile compared to other anti-anginal agents, but caution is advised with:
- Other medicines known to cause movement disorders or extrapyramidal symptoms
- Medicines affecting kidney clearance, since trimetazidine is renally eliminated
- CNS-active medicines, where additive effects on motor symptoms may occur
Always share your complete medication list with your doctor or pharmacist before starting trimetazidine 60mg.
Serious Side Effects
While trimetazidine is generally well tolerated, seek medical attention if you experience:
- New or worsening tremors, muscle stiffness, or shuffling gait
- Symptoms resembling Parkinsonism (slowness of movement, rigidity)
- Severe dizziness or fainting
- Signs of an allergic reaction: rash, swelling, difficulty breathing
- Unusual bruising or bleeding
Trimetazidine 60mg vs Other Anti-Anginal Options
| Medicine | Mechanism | Effect on Heart Rate/BP | Best Suited For |
|---|---|---|---|
| Trimetazidine 60mg | Metabolic modulator | No significant effect | Add-on therapy, intolerant to hemodynamic agents |
| Beta-blockers | Reduce heart rate/contractility | Lowers both | First-line angina therapy |
| Calcium channel blockers | Vasodilation | Lowers BP, variable HR effect | First-line, especially with hypertension |
| Nitrates | Vasodilation | Lowers BP | Acute relief and prevention |
Key Statistics
| Metric | Data Point |
|---|---|
| Drug class | Anti-anginal, metabolic agent (piperazine derivative) |
| Typical onset | Gradual improvement over days to weeks of regular use |
| Route | Oral, modified-release tablet |
| Common strength | 60mg (also available as 35mg MR/20mg formulations) |
| Renal elimination | Predominantly excreted unchanged via kidneys |
Frequently Asked Questions
What is trimetazidine 60mg used for?
Trimetazidine 60mg is used as an add-on treatment for chronic stable angina in adults who don't get adequate relief from first-line anti-anginal medicines like beta-blockers or calcium channel blockers.
How does trimetazidine 60mg work?
It works by helping the heart muscle use oxygen more efficiently during periods of reduced blood flow, shifting energy production from fatty acid to glucose metabolism, without changing heart rate or blood pressure.
What is the right dosage for trimetazidine 60mg?
The typical dose is 60mg daily, taken with meals as directed by your doctor. Dosage may be adjusted for patients with kidney impairment, so follow your prescription exactly.
Can trimetazidine 60mg be used for sudden chest pain?
No, it is not a rescue medicine. It is used for long-term prevention of angina episodes, not for treating an acute attack. Keep your prescribed emergency medication on hand.
Who should avoid trimetazidine 60mg?
Patients with Parkinson's disease, tremors, restless legs syndrome, or other movement disorders should generally avoid this medicine. Always disclose your full medical history to your doctor.
What are the common side effects of trimetazidine 60mg?
Mild nausea, headache, and dizziness are common and usually temporary. Report tremors, muscle stiffness, or signs of an allergic reaction to your doctor immediately.
Is trimetazidine 60mg safe for long-term use?
Yes, when prescribed and monitored by a cardiologist, it is generally considered safe for long-term use in appropriate patients, with periodic review for movement-related side effects.
Does trimetazidine 60mg interact with other heart medicines?
It has a low interaction profile and is often used alongside beta-blockers or calcium channel blockers, but your doctor should review all your medicines before starting therapy.
Conclusion
Trimetazidine 60mg offers a metabolic approach to managing chronic stable angina, making it a valuable add-on option for patients who need additional symptom control or cannot tolerate medicines that affect heart rate and blood pressure. It works gradually to improve the heart's energy efficiency under stress, helping reduce the frequency of angina episodes over time. As with any cardiac medication, it should be used strictly as prescribed, with regular follow-up to monitor for side effects such as movement-related symptoms. If you experience chest pain that doesn't improve, or new symptoms after starting this medicine, consult your doctor promptly.
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