TRIOLMISTRUM 40 is a potent combination medication formulated to effectively manage hypertension (high blood pressure). It contains three powerful active ingredients: Olmesartan (40mg), Amlodipine (5mg), and Hydrochlorothiazide (HCTZ) (12.5mg). This combination provides a comprehensive approach to controlling blood pressure by utilizing three different mechanisms to ensure maximum efficacy. High blood pressure is a common condition that, if left untreated, can lead to serious health complications such as heart disease, stroke, and kidney damage. TRIOLMISTRUM 40 aims to provide a reliable solution for patients seeking to maintain their blood pressure within the recommended range.

Key Ingredients:

1. Olmesartan (40mg): Olmesartan is an angiotensin II receptor blocker (ARB) that helps to relax blood vessels, allowing blood to flow more easily and lowering blood pressure.

2. Amlodipine (5mg): Amlodipine is a calcium channel blocker that relaxes and widens blood vessels by affecting the movement of calcium into the cells of the heart and blood vessel walls, thus lowering blood pressure.

3. Hydrochlorothiazide (HCTZ) (12.5mg): HCTZ is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. It helps to lower blood pressure by reducing the amount of fluid in the blood vessels.

How Does It Work?

TRIOLMISTRUM 40 works through a synergistic action of its three active ingredients to provide an all-encompassing treatment for hypertension:

• Olmesartan blocks the binding of angiotensin II to its receptors in the blood vessels, preventing vasoconstriction and promoting vasodilation, which reduces blood pressure.
• Amlodipine relaxes and dilates the blood vessels by inhibiting calcium ion influx across cell membranes in cardiac and smooth muscle.
• HCTZ increases the excretion of sodium and water by the kidneys, reducing blood volume and subsequently decreasing blood pressure.

Together, these mechanisms help to effectively lower and control blood pressure, reducing the risk of cardiovascular events.

Directions for Use:

• TRIOLMISTRUM 40 should be taken once daily, preferably at the same time each day.
• Swallow the tablet whole with water. It can be taken with or without food.
• Follow your healthcare provider's instructions on dosage and duration of use. Do not alter the dose or stop taking the medication without consulting your doctor.
• Regular monitoring of blood pressure is recommended to assess the medication's effectiveness and adjust the dose if necessary.

Side Effects:

While TRIOLMISTRUM 40 is generally well-tolerated, some patients may experience side effects, including:

• Dizziness or lightheadedness, especially when standing up quickly
• Headache
• Swelling of the ankles or feet (edema)
• Nausea or upset stomach
• Increased urination
• Fatigue

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