1000 Vildagliptin + Metformin Hydrochloride

Introduction

VILDIABATE M 1000 is a combination medication that contains Metformin (1000mg) SR and Vildagliptin (50mg). It is widely prescribed for managing Type 2 Diabetes Mellitus (T2DM). This medication helps regulate blood sugar levels by enhancing insulin production and reducing glucose production in the liver. By combining these two powerful antidiabetic agents, VILDIABATE M 1000 provides better glycemic control for patients who require dual therapy.

Key Ingredients

1. Metformin (1000mg) SR (Sustained Release):

   • A biguanide class drug that lowers glucose production in the liver and improves insulin sensitivity in muscles.

   • The sustained-release (SR) formulation ensures gradual drug release, reducing gastrointestinal side effects like nausea and diarrhea.

2. Vildagliptin (50mg):

   • A DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor) that helps enhance insulin secretion and reduce glucagon release.

   • Improves beta-cell function, which is crucial for sustained glucose control.

Mechanism of Action

Metformin (1000mg) SR:

• Reduces hepatic glucose production by inhibiting gluconeogenesis.

• Enhances insulin sensitivity, improving glucose uptake in muscle tissues.

• Reduces intestinal absorption of glucose.

Vildagliptin (50mg):

• Inhibits DPP-4 enzyme, prolonging the action of incretin hormones like GLP-1 (Glucagon-like peptide-1) and GIP (Glucose-dependent insulinotropic peptide).

• Increases insulin secretion in response to meals.

• Reduces glucagon secretion, preventing excessive glucose production by the liver.

• Helps preserve pancreatic beta-cell function, improving long-term diabetes management.

Uses of VILDIABATE M 1000

• Type 2 Diabetes Mellitus (T2DM): Used in patients where diet and exercise alone are insufficient.

• Combination Therapy: Often prescribed when monotherapy (single drug treatment) fails to provide adequate glycemic control.

• Improves Insulin Sensitivity: Reduces insulin resistance in overweight patients.

• Enhances Beta-Cell Function: Helps in the long-term sustainability of insulin production.

• Reduces Postprandial Hyperglycemia: Controls blood sugar spikes after meals.

Dosage and Administration

• Recommended Dose: Typically, one tablet per day is prescribed, preferably with a meal to minimize gastrointestinal discomfort.

• Maximum Dose: Dosage adjustments should be made by a healthcare provider based on renal function, tolerance, and glycemic response.

• Missed Dose: If a dose is missed, take it as soon as possible. If it’s close to the next dose, skip the missed dose and continue as usual. Do not double the dose.

• Overdose Risk: Symptoms may include hypoglycemia, lactic acidosis, dizziness, sweating, and irregular heartbeat. Seek immediate medical attention.

Side Effects of VILDIABATE M 1000

Common Side Effects:

• Nausea and vomiting

• Diarrhea or stomach discomfort

• Headache and dizziness

• Hypoglycemia (low blood sugar) in some cases

Serious Side Effects:

• Lactic Acidosis: A rare but serious condition associated with metformin in cases of kidney impairment.

• Pancreatitis: Severe abdominal pain and vomiting may indicate pancreatic inflammation.

• Liver Function Issues: Elevated liver enzymes may indicate liver stress, especially in patients with pre-existing liver disease.

• Allergic Reactions: Rash, swelling, or breathing difficulties may occur in rare cases.

Precautions and Warnings

• Kidney Function Monitoring:

  • Metformin is excreted by the kidneys. Patients with renal impairment should avoid or use lower doses.

• Liver Disease:

  • Vildagliptin may cause elevated liver enzymes, requiring regular liver function tests.

• Heart Disease:

  • Caution in patients with a history of heart failure or cardiovascular conditions.

• Pregnancy & Breastfeeding:

  • Not recommended unless prescribed by a doctor. Alternative diabetes treatments may be considered.

• Alcohol Consumption:

  • Avoid excessive alcohol intake as it increases the risk of lactic acidosis.

Drug Interactions

• Other Antidiabetic Drugs: Can increase hypoglycemia risk when combined with insulin or sulfonylureas.

• Diuretics & Antihypertensives: May alter blood sugar levels.

• NSAIDs & Corticosteroids: Can affect glucose metabolism, requiring dose adjustments.

• Beta-Blockers: May mask hypoglycemia symptoms.

Benefits of VILDIABATE M 1000

• Dual Mechanism of Action: Targets both insulin secretion and insulin sensitivity.

• Sustained Release Metformin: Reduces gastrointestinal side effects and provides longer glucose control.

• Improved Beta-Cell Function: Helps preserve pancreatic function in Type 2 diabetics.

• Better Glycemic Control: Lowers HbA1c levels effectively.

• Convenient Once-Daily Dosing: Enhances patient compliance and simplifies diabetes management.

Comparison with Other Diabetes Medications

Storage & Handling

• Store in a cool, dry place away from direct sunlight.

• Keep out of children’s reach.

• Do not use expired medication.

Price in India

• The price of VILDIABATE M 1000 varies based on the manufacturer and location.

• The estimated cost in India ranges between ₹250 - ₹500 per strip (10 tablets).

• It is available at local pharmacies and online medicine stores.

Conclusion

VILDIABATE M 1000 (Metformin 1000mg SR + Vildagliptin 50mg) is a highly effective oral antidiabetic medication for Type 2 Diabetes Mellitus. It provides dual benefits by improving insulin sensitivity and enhancing insulin secretion. The sustained-release formulation ensures better tolerance and patient compliance. While it offers superior glycemic control, patients should follow their doctor’s recommendations, adhere to a healthy diet and exercise regimen, and monitor their blood sugar levels regularly for optimal diabetes management.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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