Dabigatran Etexilate Capsules 75 mg ''''

Introduction

DABIGATREX 75 is a pharmaceutical formulation containing Dabigatran Etexilate (75mg), an anticoagulant used to prevent and treat blood clots. It belongs to the class of direct thrombin inhibitors and is commonly prescribed for conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke prevention in atrial fibrillation. As a novel oral anticoagulant (NOAC), Dabigatran offers advantages over traditional blood thinners like warfarin, including fewer dietary restrictions and less frequent monitoring.

Key Ingredients

Dabigatran Etexilate (75mg)

Dabigatran Etexilate is a prodrug that gets converted into its active form, Dabigatran, in the body. This active form inhibits thrombin (Factor IIa), an essential enzyme in the blood clotting process, preventing the formation of dangerous clots. Unlike warfarin, Dabigatran does not require routine INR monitoring, making it a convenient and effective choice for many patients.

Uses of DABIGATREX 75

1. Prevention of Stroke in Atrial Fibrillation (AF)

Dabigatran is widely used in patients with non-valvular atrial fibrillation to lower the risk of stroke and systemic embolism by preventing clot formation in the heart.

2. Treatment and Prevention of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE)

Dabigatran is prescribed for patients with a history of DVT or PE and for those at risk of recurrent blood clots, especially after surgery.

3. Post-Surgical Thromboprophylaxis

After major orthopedic surgeries, such as hip or knee replacement, patients are at a high risk of clot formation. Dabigatran is effective in preventing postoperative blood clots.

How Does DABIGATREX 75 Work?

Dabigatran Etexilate undergoes rapid bioconversion in the liver to its active form, Dabigatran. It then binds to thrombin, inhibiting its ability to convert fibrinogen into fibrin, a key step in clot formation. By blocking thrombin, Dabigatran reduces the formation of fibrin-rich clots, thereby lowering the risk of thrombosis.

Unlike traditional anticoagulants like warfarin, which act by inhibiting vitamin K-dependent clotting factors, Dabigatran directly inhibits thrombin, leading to a more predictable anticoagulant effect with fewer dietary restrictions and no need for frequent blood tests.

Dosage and Administration

Recommended Dosage for Different Conditions

• For Stroke Prevention in AF: 75mg or 150mg twice daily, depending on renal function and physician's assessment.

• For DVT and PE Treatment: 150mg twice daily after initial anticoagulation therapy.

• For Prevention of DVT/PE after Surgery: 110mg on the first day post-surgery, followed by 220mg daily for 10-35 days, depending on the type of surgery.

How to Take DABIGATREX 75?

• Swallow the capsule whole with a full glass of water.

• Do not chew, crush, or break the capsule, as it may alter the drug’s effectiveness.

• Take it at the same time each day for best results.

• Can be taken with or without food.

Side Effects of DABIGATREX 75

Like all medications, Dabigatran may cause some side effects, although not everyone experiences them. Common side effects include:

Common Side Effects

• Bleeding tendencies (e.g., nosebleeds, gum bleeding, prolonged bleeding from cuts)

• Gastrointestinal issues (e.g., stomach pain, nausea, diarrhea, indigestion)

• Bruising easily

• Mild skin rash or itching

Serious Side Effects (Seek Medical Attention Immediately)

• Severe bleeding (e.g., blood in urine, black stools, coughing up blood)

• Severe allergic reactions (e.g., swelling of the face, difficulty breathing, hives)

• Liver dysfunction (e.g., yellowing of skin or eyes, dark urine, fatigue)

• Spinal or epidural hematoma (increased risk in patients receiving spinal anesthesia or undergoing lumbar puncture)

Precautions and Warnings

Who Should Not Take DABIGATREX 75?

• Patients with active bleeding disorders

• Those with a history of severe kidney disease

• Patients with severe liver dysfunction

• Individuals with mechanical heart valves (Dabigatran is not recommended for such patients)

• Those with a history of serious allergic reactions to Dabigatran

Precautionary Measures

• Monitor renal function regularly, especially in elderly patients.

• Avoid alcohol, as it can increase the risk of bleeding.

• Inform healthcare providers about Dabigatran use before any surgery or dental procedures.

• Be cautious while taking NSAIDs or aspirin, as they may increase the risk of bleeding.

Drug Interactions

Medications That May Increase Bleeding Risk

• NSAIDs (e.g., ibuprofen, naproxen)

• Antiplatelet drugs (e.g., clopidogrel, aspirin)

• Other anticoagulants (e.g., warfarin, heparin)

Drugs That May Affect Dabigatran Levels

• P-glycoprotein inhibitors (e.g., amiodarone, verapamil) may increase Dabigatran levels.

• P-glycoprotein inducers (e.g., rifampin) may decrease Dabigatran levels.

Storage and Handling

• Store at room temperature (15-30°C).

• Keep in original packaging to protect from moisture.

• Do not remove the capsules from the blister pack until needed.

• Keep out of reach of children.

Benefits of DABIGATREX 75

• Effective stroke prevention in AF patients

• No routine INR monitoring required, unlike warfarin

• Rapid onset and offset of action, reducing complications

• Lower risk of major bleeding compared to warfarin

• Fewer drug and food interactions, allowing more dietary flexibility

Price and Availability

The price of DABIGATREX 75 varies depending on the manufacturer, region, and pharmacy. It is available by prescription only and can be found in most leading pharmacies and hospitals.

Conclusion

DABIGATREX 75 (Dabigatran Etexilate 75mg) is a highly effective anticoagulant used to prevent stroke, DVT, and PE. Its direct thrombin inhibition mechanism, combined with fewer monitoring requirements and better safety profile, makes it a preferred choice over traditional blood thinners. However, it should always be taken under medical supervision to minimize risks and ensure optimal therapeutic benefits. If you experience any unusual bleeding or side effects, seek medical attention immediately. Always follow the prescribed dosage and inform your doctor about any other medications you are taking to avoid potential drug interactions.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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