Divalproex Sodium Extended-Release Tablets 750 mg – DIOWELPREX ER 750 by Steris Healthcare

Introduction

DIOWELPREX ER 750, an advanced extended-release formulation of divalproex sodium 750 mg, serves as a cornerstone in long-term neuropsychiatric care. Developed by Steris Healthcare Pvt Ltd, this high-strength medication is engineered to ensure stable plasma concentrations over an extended duration, optimizing both efficacy and tolerability.

What is DIOWELPREX ER 750?

DIOWELPREX ER 750 is a high-strength extended-release tablet containing divalproex sodium 750 mg, a widely used anticonvulsant and mood stabilizer. It combines valproic acid and sodium valproate into a single compound that releases gradually into the bloodstream. This controlled delivery system ensures steady therapeutic levels, reducing the risk of peak-related side effects and providing enhanced seizure control and mood stabilization.

Uses of DIOWELPREX ER 750

1. Epilepsy:
DIOWELPREX ER 750 is effective against various types of seizures including:

• Generalized tonic-clonic seizures

• Complex partial seizures

• Absence seizures

It works by stabilizing electrical activity in the brain and reducing the frequency and severity of seizure episodes.

2. Bipolar Disorder:
It is indicated for the treatment of acute manic or mixed episodes associated with bipolar I disorder. Additionally, it aids in the long-term maintenance of mood stability and prevention of relapses.

3. Migraine Prophylaxis:
DIOWELPREX ER 750 is prescribed to reduce the frequency of migraine headaches in individuals with a history of recurrent migraines.

How Divalproex Sodium Works

Divalproex sodium increases the levels of gamma-aminobutyric acid (GABA) in the brain, an inhibitory neurotransmitter that calms excessive neuronal activity. It also alters sodium and calcium channel function, contributing to mood stabilization and seizure prevention. This multifaceted mechanism makes it suitable for various neurological and psychiatric conditions.

Dosage & Administration

• Initial Dosage: Typically begins at 10–15 mg/kg/day and is increased gradually.

• Maintenance Dosage: Adjusted based on therapeutic response and serum valproate levels.

• Route: Oral; swallow whole, do not chew or crush.

• With Food: Can be taken with or without meals.

Dosage must be individualized under the guidance of a healthcare provider.

Side Effects of Divalproex 750 mg

Common Side Effects:

• Gastrointestinal upset (nausea, vomiting)

• Headache and dizziness

• Fatigue or drowsiness

• Weight gain

• Tremors

• Hair thinning

Serious Side Effects:

• Liver failure, especially in pediatric patients

• Pancreatitis

• Low platelet count (thrombocytopenia)

• Hyperammonemia

• Suicidal thoughts or behavior

Seek immediate medical attention if serious side effects occur.

Precautions Before Using

• Not advised for pregnant women unless no safer alternatives are available.

• Periodic liver function tests and complete blood counts are required.

• Caution in elderly patients or those with renal impairment.

• Avoid alcohol and CNS depressants while on treatment.

• Monitor for signs of liver damage or mood disturbances.

Drug Interactions

Divalproex sodium may interact with:

• Carbapenems (e.g., meropenem): May lower valproate levels drastically

• Aspirin/Warfarin: Increased bleeding risk

• Phenytoin/Lamotrigine/Phenobarbital: Altered serum concentrations

• CNS depressants (e.g., benzodiazepines): Enhanced sedation

• Oral contraceptives: May become less effective

Consult your doctor before combining DIOWELPREX ER 750 with other medications.

Why Choose Steris Healthcare Pvt Ltd?

Steris Healthcare Pvt Ltd stands at the forefront of India's pharmaceutical sector, delivering innovative and patient-centric formulations that align with global standards. DIOWELPREX ER 750 is a testament to its dedication to neurological and psychiatric wellness.

• WHO-GMP certified manufacturing practices

• Robust quality assurance and R&D support

• Trusted by physicians across India

• Affordable and widely available in both metro and rural markets

With Steris Healthcare, patients are assured of efficacy, affordability, and safety.

Frequently Asked Questions (FAQs)

Q1. Can DIOWELPREX ER 750 be taken at night?
Yes. Taking it at night may reduce drowsiness experienced during the day.

Q2. How long should I take DIOWELPREX ER 750?
It is intended for long-term use under medical supervision. Do not stop without consulting your doctor.

Q3. Is routine blood monitoring necessary?
Yes. Liver function, blood counts, and serum valproate levels should be monitored regularly.

Q4. Can I take this medication during pregnancy?
It poses a risk to fetal development. Use only when essential and with medical oversight.

Q5. What happens if I miss a dose?
Take it as soon as remembered, but skip it if it's near your next scheduled dose. Never double dose.

Conclusion

DIOWELPREX ER 750 is a clinically proven solution for patients dealing with epilepsy, bipolar mood disorders, or frequent migraines. Its extended-release mechanism ensures consistent drug levels, minimizing side effects while maximizing efficacy. When paired with Steris Healthcare’s high manufacturing standards and physician trust, DIOWELPREX ER 750 becomes a preferred choice for long-term neuropsychiatric therapy.