Empagliflozin and Metformin Hydrochloride: Dual Therapy for Effective Diabetes Management

Introduction

GLIEMPAFLOZIN MET ER is a combination medication containing Empagliflozin (25mg) and Metformin Hydrochloride (Extended Release) 1000mg. It is primarily used for the management of Type 2 Diabetes Mellitus (T2DM), helping control blood sugar levels in individuals who require multiple mechanisms of action to maintain glycemic control.

Key Ingredients

Empagliflozin (25mg)

Empagliflozin is a Sodium-Glucose Cotransporter-2 (SGLT2) inhibitor, which works by reducing glucose reabsorption in the kidneys, thereby promoting glucose excretion through urine. This process helps lower blood sugar levels and may also contribute to weight loss and cardiovascular benefits.

Metformin Hydrochloride (Extended Release) 1000mg

Metformin belongs to the biguanide class of antidiabetic medications. It primarily works by decreasing hepatic glucose production and improving insulin sensitivity in the body, making it a widely prescribed drug for diabetes management. The extended-release formulation ensures gradual absorption, minimizing gastrointestinal side effects.

Key Benefits of GLIEMPAFLOZIN MET ER

1. Improved Blood Sugar Control – The combination of Empagliflozin and Metformin ER effectively lowers blood sugar levels in individuals with Type 2 Diabetes Mellitus.

2. Dual Mechanism of Action – Empagliflozin promotes glucose excretion through urine, while Metformin reduces glucose production and enhances insulin sensitivity.

3. Weight Management – Empagliflozin aids in weight loss by excreting excess glucose, making it beneficial for overweight diabetic patients.

4. Cardiovascular Protection – Studies suggest that Empagliflozin has cardiovascular benefits, reducing the risk of heart failure and other cardiovascular events in diabetic patients.

5. Long-Lasting Glycemic Control – The extended-release Metformin formulation ensures steady glucose control throughout the day.

6. Reduced Risk of Hypoglycemia – Unlike some diabetes medications, GLIEMPAFLOZIN MET ER has a lower risk of causing dangerously low blood sugar levels.

7. Improved Kidney Health – Empagliflozin has been shown to provide renal benefits, particularly for patients with diabetic kidney disease.

How Does GLIEMPAFLOZIN MET ER Work?

Mechanism of Action

• Empagliflozin (SGLT2 Inhibitor) blocks glucose reabsorption in the kidneys, leading to increased glucose excretion via urine.

• Metformin (Biguanide) reduces glucose production in the liver and improves insulin sensitivity, enhancing glucose uptake by cells.

• The combination works synergistically to provide better glycemic control with a reduced risk of side effects.

Directions for Use

• Dosage: GLIEMPAFLOZIN MET ER should be taken once daily with food to reduce gastrointestinal side effects.

• Swallow whole – Do not crush or chew the extended-release tablets.

• Follow your doctor’s advice regarding dosage adjustments based on blood sugar levels.

• Maintain a healthy lifestyle with a balanced diet and regular physical activity for optimal diabetes management.

Side Effects of GLIEMPAFLOZIN MET ER

Common Side Effects

• Increased urination due to Empagliflozin’s diuretic effect

• Nausea, diarrhea, or stomach discomfort (related to Metformin)

• Dehydration or dizziness

• Mild weight loss

Serious Side Effects (Seek medical help if these occur)

• Lactic Acidosis (a rare but serious condition associated with Metformin)

• Ketoacidosis (a serious condition linked to SGLT2 inhibitors like Empagliflozin)

• Urinary tract infections or genital infections

• Severe allergic reactions (rash, swelling, difficulty breathing)

Precautions and Warnings

1. Kidney Function Monitoring – Patients with impaired kidney function should use GLIEMPAFLOZIN MET ER with caution, as both components are eliminated through the kidneys.

2. Avoid in Severe Liver Disease – Metformin is contraindicated in patients with significant liver disease.

3. Hydration is Key – Due to Empagliflozin’s diuretic effect, drink plenty of water to prevent dehydration.

4. Not for Type 1 Diabetes – This medication is only for Type 2 Diabetes and should not be used in Type 1 Diabetes or diabetic ketoacidosis.

5. Caution in Elderly Patients – Risk of dehydration and kidney impairment is higher in older adults.

Drug Interactions

• Diuretics: Increased risk of dehydration and low blood pressure.

• Insulin or Sulfonylureas: Increased risk of hypoglycemia.

• NSAIDs and ACE Inhibitors: May impact kidney function when combined with GLIEMPAFLOZIN MET ER.

Price and Availability in India

The cost of Empagliflozin (25mg) and Metformin Hydrochloride 1000mg varies based on brand and pharmacy location. On average, a strip of 10 tablets ranges from ₹300 to ₹600. Prices may vary, and patients are encouraged to check with their local pharmacy or online medicine retailers for discounts.

Conclusion

GLIEMPAFLOZIN MET ER is an effective combination therapy for managing Type 2 Diabetes Mellitus, offering enhanced glycemic control, weight loss benefits, and cardiovascular protection. Its dual mechanism of action makes it a preferred choice for patients needing additional glucose-lowering benefits beyond Metformin alone. However, regular monitoring, adherence to lifestyle modifications, and consultation with a healthcare provider are essential for optimal results.

Always take GLIEMPAFLOZIN MET ER as prescribed and discuss any concerns with your doctor to ensure safe and effective diabetes management.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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