Glibenclamide 5 mg

Introduction

GLIBIMIDE 5, a formulation containing Glibenclamide 5 mg, is a pharmaceutical product used primarily for the management of type 2 diabetes. It belongs to the class of sulfonylureas, a group of oral medications designed to lower blood sugar levels in patients who have not achieved adequate control with diet and exercise alone. Glibenclamide (also known as Glyburide) works by stimulating the pancreas to release more insulin, thereby aiding in better blood glucose control.

The medication is commonly prescribed when lifestyle changes, such as improved diet and exercise, are not sufficient to manage diabetes. Understanding how GLIBIMIDE 5 works, its uses, dosages, potential side effects, and other relevant information is essential for patients taking it.

Key Ingredients: Glibenclamide (5 mg)

• Glibenclamide (5 mg): The active ingredient in GLIBIMIDE 5, Glibenclamide, is a second-generation sulfonylurea. It helps regulate blood sugar levels by enhancing the release of insulin from the pancreas and increasing the body's sensitivity to insulin. By doing so, it effectively lowers blood glucose levels and helps manage type 2 diabetes.
• Inactive Ingredients: The inactive ingredients vary based on the manufacturer but typically include binding agents, fillers, and stabilizers to ensure the proper form and effectiveness of the tablet.

How Does Glibenclamide Work?

Glibenclamide is a member of the sulfonylurea class of drugs, which function by interacting with sulfonylurea receptors on the surface of pancreatic beta cells. This interaction results in the closing of ATP-sensitive potassium channels, which, in turn, leads to depolarization of the cell membrane. The depolarization causes calcium channels to open, allowing an influx of calcium ions into the cell. This increased calcium concentration triggers the release of insulin from the pancreas.

By increasing insulin secretion, Glibenclamide helps lower blood glucose levels. Additionally, it enhances the body’s ability to use the insulin it produces more effectively. However, Glibenclamide does not work in patients with type 1 diabetes or those who are insulin-dependent since it only stimulates the pancreas to release insulin in individuals who still have functional pancreatic beta cells.

Uses of GLIBIMIDE 5 (Glibenclamide 5 mg)

GLIBIMIDE 5 is primarily prescribed to manage type 2 diabetes mellitus. Type 2 diabetes is characterized by insulin resistance, where the body does not respond properly to insulin, and progressive beta-cell dysfunction, where the pancreas can no longer produce enough insulin to control blood sugar levels. In this condition, GLIBIMIDE 5 can be used either alone or in combination with other anti-diabetic medications.

Key Uses:

1. Management of Type 2 Diabetes: GLIBIMIDE 5 helps in controlling blood glucose levels in adults with type 2 diabetes, particularly when lifestyle changes like diet and exercise have proven ineffective.
2. Adjunct Therapy: It can be combined with other oral anti-diabetic drugs (such as metformin) or insulin in patients who need additional glycemic control.

Dosage of GLIBIMIDE 5 (Glibenclamide 5 mg)

The dosage of GLIBIMIDE 5 is individualized based on the patient's blood glucose levels, body weight, and overall health condition. It is essential to follow the doctor’s instructions and adjust the dosage as needed.

• Starting Dose: Typically, the starting dose for an adult is 5 mg per day, taken once daily with breakfast or the first meal of the day. This helps reduce the risk of hypoglycemia.
• Maintenance Dose: The dose can be gradually increased depending on the patient’s blood glucose levels. The maximum recommended dose is generally 20 mg per day.
• Elderly Patients: Older adults may be more sensitive to the effects of Glibenclamide, so doctors usually start them on a lower dose and carefully monitor blood glucose levels.
• Combination Therapy: In some cases, GLIBIMIDE 5 may be prescribed alongside other diabetes medications to achieve optimal glucose control.

How to Take GLIBIMIDE 5

1. Oral Administration: GLIBIMIDE 5 should be taken by mouth with or just after a meal to minimize the risk of stomach upset.
2. Consistent Timing: To maintain stable blood sugar levels, it is best to take the medication at the same time every day.
3. Missed Dose: If a dose is missed, take it as soon as you remember unless it is nearly time for your next dose. In that case, skip the missed dose and resume the regular dosing schedule. Never take two doses at once.

Side Effects of GLIBIMIDE 5 (Glibenclamide 5 mg)

Like all medications, GLIBIMIDE 5 can cause side effects, although not everyone experiences them. Common and severe side effects are as follows:

1. Common Side Effects:

   • Hypoglycemia (Low Blood Sugar): The most significant risk with GLIBIMIDE 5 is hypoglycemia. Symptoms may include sweating, dizziness, trembling, hunger, and confusion.
   • Weight Gain: Some patients may experience weight gain due to increased insulin secretion.
   • Gastrointestinal Issues: Nausea, vomiting, abdominal discomfort, and indigestion are possible side effects.

2. Serious Side Effects:

   • Severe Hypoglycemia: If blood sugar drops too low, it can lead to seizures, unconsciousness, or even death. Immediate medical attention is required if severe symptoms of hypoglycemia occur.
   • Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing could indicate an allergic reaction.
   • Hepatic Dysfunction: Liver-related issues may include jaundice, dark urine, or unexplained fatigue.
   • Hematological Disorders: Some people may experience low blood cell counts, including white blood cells, red blood cells, and platelets.

Precautions and Warnings

Before taking GLIBIMIDE 5, patients should inform their healthcare provider about any existing medical conditions, particularly:

1. Hypoglycemia: Patients at risk of low blood sugar, such as those with irregular meal patterns or alcohol consumption, should use GLIBIMIDE 5 with caution.
2. Kidney and Liver Disease: Patients with renal or hepatic impairments may need dose adjustments or alternative therapies, as Glibenclamide is processed in the liver and excreted by the kidneys.
3. Pregnancy and Breastfeeding: Glibenclamide is not recommended during pregnancy due to potential harm to the fetus. It can also pass into breast milk, so breastfeeding mothers should consult their doctor before taking the medication.
4. Other Medications: Inform your doctor about any other medications being taken, as certain drugs can interact with GLIBIMIDE 5 and affect its effectiveness or increase the risk of side effects. This includes diuretics, steroids, and certain antifungal medications.

Interactions with Other Medications

Several medications may interact with GLIBIMIDE 5, either increasing the risk of hypoglycemia or reducing its effectiveness. Some notable drug interactions include:

• Beta-blockers: These can mask the symptoms of hypoglycemia, making it harder to detect.
• Anticoagulants: Drugs like warfarin may interact with GLIBIMIDE 5, requiring adjustments in dosing.
• Corticosteroids: These may elevate blood glucose levels and counteract the effects of GLIBIMIDE 5.

Price and Availability in India

GLIBIMIDE 5 is available in most pharmacies across India. The cost can vary depending on the manufacturer and the pharmacy, but it is generally affordable for most patients. It is available in tablet form, with 5 mg being the most common dosage. The price for a strip of 10 tablets usually ranges from INR 30 to INR 60.

Conclusion

GLIBIMIDE 5 (Glibenclamide 5 mg) is an essential medication in the management of type 2 diabetes. By stimulating the pancreas to release insulin, it helps patients achieve better control over their blood sugar levels. While effective, it must be taken carefully, with proper monitoring, as it can lead to side effects like hypoglycemia and weight gain.

Patients using GLIBIMIDE 5 should closely follow their doctor's instructions regarding dosage, timing, and lifestyle modifications. Regular blood sugar testing, a healthy diet, and regular physical activity are key to achieving optimal results and minimizing risks. Always consult your healthcare provider before making any changes to your treatment plan.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW