Glibenclamide 5 mg + Metformin SR 500

Introduction

Glibemide Forte is an effective antidiabetic medication that combines two potent drugs: Glibenclamide (5mg) and Metformin HCl (500mg). It is primarily used for the management of Type 2 Diabetes Mellitus (T2DM) in patients who require a combination therapy to maintain blood glucose levels within a normal range. This combination medication helps in improving glycemic control, reducing insulin resistance, and preventing complications associated with diabetes.

Key Ingredients

Glibenclamide (5mg)

Glibenclamide, also known as Glyburide, is a second-generation sulfonylurea that works by stimulating the pancreas to release insulin. It helps lower blood sugar levels in people with Type 2 Diabetes by increasing insulin secretion from the beta cells of the pancreas.

Metformin HCl (500mg)

Metformin is a biguanide that plays a crucial role in reducing hepatic glucose production and enhancing insulin sensitivity. It lowers blood glucose levels by decreasing intestinal glucose absorption and improving glucose utilization in the body.

Mechanism of Action

The dual action of Glibenclamide and Metformin makes Glibemide Forte an effective choice for diabetes management.

1. Glibenclamide stimulates the pancreatic beta cells to produce more insulin, thereby helping in reducing blood glucose levels.

2. Metformin works by decreasing glucose production in the liver and increasing insulin sensitivity in muscle and fat tissues, leading to improved glucose uptake.

3. Together, they provide better glycemic control, reduce the risk of hypoglycemia, and help manage diabetes-related complications.

Uses of Glibemide Forte

• Effective in managing Type 2 Diabetes Mellitus.

• Helps improve insulin sensitivity and reduces insulin resistance.

• Lowers fasting blood glucose (FBG) and postprandial blood glucose (PPBG) levels.

• Prevents diabetic complications such as neuropathy, nephropathy, and retinopathy.

• Reduces the risk of cardiovascular diseases in diabetic patients.

• Aids in weight management in diabetic individuals by controlling glucose metabolism.

Dosage and Administration

The dosage of Glibemide Forte should be prescribed by a healthcare professional based on the patient’s blood glucose levels and individual needs.

Recommended Dosage:

• The usual starting dose is one tablet per day, taken with meals.

• The dose may be adjusted gradually based on blood sugar levels.

• Maximum dosage should not exceed 20mg of Glibenclamide and 2000mg of Metformin per day.

• Regular blood sugar monitoring is essential for effective diabetes control.

Missed Dose:

• If a dose is missed, take it as soon as possible.

• If it is close to the next dose, skip the missed dose and continue the regular schedule.

• Do not double the dose to make up for a missed one.

Overdose:

An overdose of Glibemide Forte can lead to severe hypoglycemia, characterized by:

• Sweating

• Dizziness

• Confusion

• Tremors

• Unconsciousness

• Seizures

Seek immediate medical attention in case of overdose.

Side Effects of Glibemide Forte

Like all medications, Glibemide Forte may cause some side effects. These can range from mild to severe and vary among individuals.

Common Side Effects:

• Nausea

• Vomiting

• Diarrhea

• Stomach pain

• Dizziness

• Headache

Serious Side Effects:

• Severe hypoglycemia (shakiness, confusion, sweating, and blurred vision)

• Lactic acidosis (muscle pain, difficulty breathing, and extreme tiredness)

• Liver dysfunction (yellowing of the skin and eyes, dark urine)

• Kidney problems (reduced urine output, swelling in feet and ankles)

• Allergic reactions (rash, itching, swelling, breathing difficulties)

Seek medical help immediately if you experience any of these serious side effects.

Precautions and Warnings

• Not recommended for Type 1 Diabetes or diabetic ketoacidosis.

• Avoid alcohol consumption as it can increase the risk of lactic acidosis.

• Not suitable for individuals with severe kidney or liver impairment.

• Pregnant and breastfeeding women should consult a doctor before use.

• Elderly patients should use it cautiously to prevent hypoglycemia.

• Monitor blood sugar levels regularly to adjust the dose accordingly.

Drug Interactions

Glibemide Forte may interact with other medications, altering its effectiveness.

Drugs that may increase the risk of hypoglycemia:

• Insulin

• Other sulfonylureas

• Beta-blockers

• MAO inhibitors

Drugs that may reduce the effect of Glibemide Forte:

• Corticosteroids

• Thiazide diuretics

• Oral contraceptives

• Thyroid hormones

Inform your doctor about all the medications, supplements, and herbal products you are taking before starting Glibemide Forte.

Storage Instructions

• Store Glibemide Forte at room temperature (15-30°C).

• Keep it away from moisture, direct sunlight, and heat.

• Keep out of reach of children.

• Do not use it after the expiry date mentioned on the packaging.

Price and Availability in India

The price of Glibemide Forte may vary depending on the manufacturer and the pharmacy. It is readily available in medical stores and online pharmacies across India.

Estimated Price Range:

• Blister pack (10 tablets): ₹30 - ₹100

• 30-day supply: ₹100 - ₹300

Prices may differ based on brand, region, and discounts available online.

Conclusion

Glibemide Forte is a highly effective combination therapy for Type 2 Diabetes Mellitus, offering dual benefits of insulin stimulation and improved insulin sensitivity. It provides better glycemic control, reduces the risk of diabetic complications, and enhances quality of life. However, proper dosage, regular monitoring, and medical supervision are crucial to avoid side effects and complications.

Before starting Glibemide Forte, consult a healthcare professional to ensure safe and effective diabetes management.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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