GLICLAGLAZE M 40: USES, PRICE AND ALL DETAILS..

GLICLAGLAZE M 40

gliclazide (40mg),Metformin (500 mg)

GLICLAGLAZE M 40 is a combination medication containing Gliclazide (40 mg) and Metformin Hydrochloride (500 mg). This medication is used to manage blood sugar levels in adults with type 2 diabetes mellitus. It combines two different mechanisms of action to provide more effective glycemic control.

Uses
Type 2 Diabetes Mellitus: GLICLAGLAZE M 40 is prescribed to help lower and control blood sugar levels in patients with type 2 diabetes, particularly when diet, exercise, and single-drug therapy are not sufficient.
Mechanism of Action
Gliclazide: A sulfonylurea that stimulates insulin secretion from the pancreatic beta cells. It works by closing ATP-sensitive potassium channels on the beta-cell membrane, leading to depolarization and calcium influx, which triggers insulin release.
Metformin Hydrochloride: A biguanide that reduces hepatic glucose production, decreases intestinal absorption of glucose, and enhances insulin sensitivity by increasing peripheral glucose uptake and utilization.
Dosage
Typical Dose: One tablet of GLICLAGLAZE M 40 taken once or twice daily with meals. The dosage should be individualized based on the patient's current regimen, effectiveness, and tolerance.
Side Effects
Common: Gastrointestinal symptoms such as nausea, vomiting, diarrhea, abdominal pain, and a metallic taste. Hypoglycemia, especially when combined with other antidiabetic medications.
Serious: Lactic acidosis (rare but serious condition related to Metformin), severe hypoglycemia, liver dysfunction, and hematological changes.
Contraindications
Type 1 diabetes or diabetic ketoacidosis.
Severe renal or hepatic impairment.
Known hypersensitivity to Gliclazide, Metformin, or any other component of the formulation.

Interactions
Medications: Beta-blockers, corticosteroids, diuretics, ACE inhibitors, and other medications that may affect blood glucose levels.
Alcohol: Increases the risk of lactic acidosis and hypoglycemia.
Monitoring
Renal Function: Periodic assessment, especially in elderly patients or those with pre-existing renal conditions.
Liver Function: Regular tests to detect any hepatic abnormalities.
Benefits
Effective Glycemic Control: The combination of Gliclazide and Metformin offers a dual mechanism to better manage blood sugar levels.
Convenience: Combines two medications into one tablet, simplifying the treatment regimen and potentially improving patient adherence.
Price
The cost of GLICLAGLAZE M 40 can vary depending on the manufacturer and the pharmacy. Patients should check with their local pharmacies for specific pricing.
Conclusion
GLICLAGLAZE M 40 is a potent combination therapy for managing type 2 diabetes mellitus. By combining Gliclazide and Metformin, it provides comprehensive blood glucose control, which is crucial for preventing diabetes-related complications. Patients should use this medication under the supervision of a healthcare provider, with regular monitoring to ensure safety and effectiveness.Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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