Gliclazide 80 mg & Metformin 500 mg

Introduction

GLICLAGLAZE M 80 is a combination medication that contains Gliclazide (80mg) and Metformin (500mg). This formulation is used for managing Type 2 Diabetes Mellitus (T2DM) effectively. It combines the benefits of Gliclazide, a sulfonylurea that stimulates insulin secretion, and Metformin, a biguanide that enhances insulin sensitivity and reduces glucose production in the liver. This dual mechanism helps regulate blood sugar levels and prevents complications related to diabetes.

Key Ingredients

1. Gliclazide (80mg)

• Belongs to the sulfonylurea class of antidiabetic drugs.

• Stimulates insulin secretion from pancreatic beta cells.

• Reduces postprandial and fasting blood glucose levels.

• Exhibits antioxidant and anti-inflammatory properties, which provide cardiovascular benefits.

2. Metformin (500mg)

• Belongs to the biguanide class.

• Enhances insulin sensitivity and reduces hepatic glucose production.

• Lowers intestinal absorption of glucose.

• Helps in weight management and reduces the risk of hypoglycemia.

Uses of GLICLAGLAZE M 80

• Management of Type 2 Diabetes Mellitus (T2DM).

• Helps in controlling high blood sugar levels and prevents diabetes-related complications.

• Improves insulin sensitivity and pancreatic function.

• Reduces the risk of cardiovascular diseases, neuropathy, and nephropathy in diabetic patients.

• Aids in weight management, especially in overweight diabetic patients.

How Does GLICLAGLAZE M 80 Work?

GLICLAGLAZE M 80 works through a dual mechanism:

1. Gliclazide stimulates the pancreas to produce more insulin, thereby increasing glucose uptake by the cells.

2. Metformin reduces liver glucose production and enhances insulin action, making the body more responsive to insulin.

This combination ensures steady glucose control while minimizing the risk of hypoglycemia and excessive weight gain.

Dosage & Administration

• The usual dose is one tablet once or twice daily, preferably with meals.

• The dosage may vary based on doctor’s recommendation, considering blood sugar levels and overall health condition.

• Regular monitoring of blood glucose levels is essential for optimal dose adjustment.

• Do not crush or chew the tablet; swallow it whole with water.

Precautions & Warnings

1. Contraindications:

• Not for Type 1 Diabetes or diabetic ketoacidosis.

• Patients with severe kidney or liver impairment should avoid this medication.

• Avoid if allergic to sulfonylureas or biguanides.

2. Warnings:

• May cause low blood sugar (hypoglycemia) if combined with excessive alcohol or skipped meals.

• Metformin may cause lactic acidosis, a rare but serious condition.

• Not recommended for pregnant or breastfeeding women without medical advice.

• Avoid alcohol consumption, as it may increase the risk of lactic acidosis and hypoglycemia.

Side Effects of GLICLAGLAZE M 80

While GLICLAGLAZE M 80 is generally well-tolerated, some patients may experience side effects, including:

Common Side Effects:

• Nausea and vomiting

• Diarrhea

• Stomach pain

• Mild hypoglycemia (dizziness, hunger, sweating)

Serious Side Effects (Seek Medical Attention):

• Severe hypoglycemia (confusion, seizures, unconsciousness)

• Lactic acidosis (rapid breathing, muscle pain, weakness)

• Liver dysfunction (yellowing of the skin or eyes, dark urine)

• Skin allergies (rash, itching, swelling)

Drug Interactions

GLICLAGLAZE M 80 may interact with other medications, including:

• Beta-blockers – May mask symptoms of hypoglycemia.

• Diuretics and corticosteroids – May raise blood sugar levels.

• Alcohol – Increases the risk of lactic acidosis.

• Antifungals & antibiotics (Fluconazole, Rifampin) – Can affect blood sugar control.

Benefits of GLICLAGLAZE M 80

1. Effective Blood Sugar Control:

• Maintains balanced glucose levels by regulating insulin secretion and sensitivity.

2. Cardiovascular Protection:

• Gliclazide has antioxidant properties, reducing the risk of heart complications in diabetes.

3. Weight-Neutral:

• Unlike other sulfonylureas, Gliclazide has a lower tendency for weight gain.

4. Reduces Insulin Resistance:

• Metformin improves glucose utilization and prevents insulin resistance.

5. Prevents Diabetes Complications:

• Reduces risks of diabetic neuropathy, nephropathy, and retinopathy.

Who Should Take GLICLAGLAZE M 80?

GLICLAGLAZE M 80 is suitable for patients:

• Diagnosed with Type 2 Diabetes Mellitus.

• Requiring a combination of insulin stimulation and glucose regulation.

• Struggling with postprandial blood sugar spikes.

• Looking for a weight-friendly diabetes medication.

Who Should Avoid GLICLAGLAZE M 80?

This medication is NOT recommended for:

• Type 1 Diabetes patients.

• People with severe kidney or liver disease.

• Pregnant or breastfeeding women without doctor approval.

• Individuals with sulfonylurea or metformin allergy.

Lifestyle Modifications for Better Diabetes Control

While taking GLICLAGLAZE M 80, lifestyle changes enhance its effectiveness:

1. Healthy Diet:

• Follow a low-glycemic index (GI) diet.

• Increase fiber-rich foods like whole grains, vegetables, and legumes.

• Avoid processed sugar and trans fats.

2. Regular Exercise:

• Engage in 30-45 minutes of exercise daily (brisk walking, jogging, cycling).

• Strength training helps improve insulin sensitivity.

3. Regular Monitoring:

• Check blood sugar levels regularly to assess treatment effectiveness.

• Schedule routine doctor check-ups for dose adjustments.

4. Hydration and Sleep:

• Drink adequate water to help kidney function.

• Get 7-8 hours of sleep to regulate insulin levels.

FAQs on GLICLAGLAZE M 80

1. Can GLICLAGLAZE M 80 cause weight gain?

• No, Metformin helps in weight management, though Gliclazide may cause slight weight gain in some cases.

2. What should I do if I miss a dose?

• Take it as soon as possible but skip it if it’s almost time for the next dose.

• Do not double-dose to make up for a missed dose.

3. Can I stop taking GLICLAGLAZE M 80 suddenly?

• No, stopping suddenly may cause blood sugar spikes. Consult a doctor before discontinuing.

4. Is GLICLAGLAZE M 80 safe for elderly patients?

• Yes, but dose adjustments may be necessary to avoid hypoglycemia.

5. How long does it take to see results?

• Blood sugar levels start improving within a few days, but full benefits may take a few weeks.

Conclusion

GLICLAGLAZE M 80 is an effective and widely used medication for Type 2 Diabetes, combining the benefits of Gliclazide (80mg) & Metformin (500mg). It helps control blood sugar levels, enhances insulin action, and prevents diabetes-related complications. To achieve the best results, it is crucial to follow a balanced diet, regular exercise, and routine monitoring. Always consult a healthcare provider before making any changes to your diabetes treatment plan.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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