Glimipiride 0.5 mg + Metformin SR 500 mg

Introduction

SEIZMET G 0.5 is a combination medication containing Glimepiride (0.5mg) and Metformin SR (500mg), which is widely prescribed for managing Type 2 Diabetes Mellitus (T2DM). This formulation helps regulate blood sugar levels effectively by combining the benefits of a sulfonylurea (Glimepiride) and a biguanide (Metformin). It enhances insulin secretion, improves insulin sensitivity, and reduces glucose production in the liver.

This detailed guide will explore the composition, benefits, mechanism of action, dosage, precautions, potential side effects, and pricing of SEIZMET G 0.5.

Key Ingredients

1. Glimepiride (0.5mg)

   • A sulfonylurea that stimulates pancreatic beta cells to produce more insulin.

   • Helps in lowering postprandial (after-meal) blood glucose levels.

   • Enhances the body's natural response to insulin.

2. Metformin SR (500mg) (Sustained Release)

   • A biguanide that reduces liver glucose production.

   • Enhances insulin sensitivity in muscle cells.

   • Delays glucose absorption from the intestines, leading to better glycemic control.

   • SR (Sustained Release) formulation ensures gradual and prolonged action.

Key Benefits of SEIZMET G 0.5

• Effective Blood Sugar Control: Helps in reducing fasting and postprandial blood sugar levels.

• Dual Mechanism of Action: Combines insulin-stimulating (Glimepiride) and insulin-sensitizing (Metformin) effects for comprehensive control.

• Reduces Insulin Resistance: Metformin improves insulin action in muscle and fat tissues.

• Minimizes Risk of Hypoglycemia: The low dose of Glimepiride (0.5mg) reduces the chances of sudden blood sugar drops.

• Weight Management Support: Metformin helps prevent weight gain, making it suitable for overweight diabetic patients.

• Cardiovascular Benefits: Studies suggest that Metformin reduces cardiovascular risk factors in diabetics.

• Sustained-Release Formula: Ensures better gastrointestinal tolerance and longer-lasting effects.

How Does SEIZMET G 0.5 Work?

1. Stimulating Insulin Release (Glimepiride)

   • Activates pancreatic beta cells to release more insulin.

   • Increases glucose uptake by cells, reducing blood sugar levels.

2. Reducing Glucose Production (Metformin)

   • Suppresses excess glucose production in the liver.

   • Enhances insulin sensitivity in muscles and tissues.

   • Delays glucose absorption from the intestines, leading to better post-meal control.

This synergistic effect makes SEIZMET G 0.5 highly effective in managing diabetes with fewer side effects.

Recommended Dosage and Administration

• Usual Dosage: As prescribed by the physician, usually once or twice daily with meals.

• Best Time to Take: Preferably before or with breakfast/dinner to reduce gastrointestinal discomfort.

• Swallow Whole: Do not crush or chew the tablet to ensure sustained-release action.

• Missed Dose: If missed, take it as soon as possible, but do not double the dose.

• Overdose Risk: Overconsumption may cause severe hypoglycemia (low blood sugar) – seek immediate medical attention if symptoms occur.

Possible Side Effects

While SEIZMET G 0.5 is generally well-tolerated, some users may experience side effects such as:

Common Side Effects

• Nausea and Vomiting

• Diarrhea

• Mild Hypoglycemia (Dizziness, Sweating, Hunger)

• Abdominal Pain or Bloating

• Fatigue and Weakness

Serious Side Effects (Seek Medical Help Immediately)

• Severe Hypoglycemia (Confusion, Seizures, Fainting)

• Lactic Acidosis (Rare but Fatal) – Symptoms include breathing difficulty, muscle pain, and extreme tiredness.

• Liver Dysfunction (Jaundice, Dark Urine, Persistent Nausea)

• Allergic Reactions (Rash, Swelling, Itching, Breathing Problems)

Precautions & Warnings

• Avoid Alcohol: May increase the risk of lactic acidosis and hypoglycemia.

• Kidney and Liver Patients: Use with caution in renal or hepatic impairment.

• Pregnancy & Breastfeeding: Consult your doctor before use.

• Monitor Blood Sugar Levels: Regular glucose monitoring is necessary for dosage adjustment.

• Be Cautious While Driving: Hypoglycemia may cause dizziness or blurred vision.

Drug Interactions

• NSAIDs (Ibuprofen, Aspirin): Can enhance hypoglycemic effects.

• Beta-Blockers (Metoprolol, Propranolol): May mask low blood sugar symptoms.

• Diuretics (Furosemide, Hydrochlorothiazide): Can reduce Metformin effectiveness.

• Steroids (Prednisolone, Cortisone): May increase blood sugar levels.

Always inform your doctor about all ongoing medications before starting SEIZMET G 0.5.

Price & Availability in India

• Price Range: ₹150 – ₹350 per strip (10 tablets) depending on brand and region.

• Availability: Easily accessible in local pharmacies and online drug stores.

Conclusion

SEIZMET G 0.5 (Glimepiride 0.5mg + Metformin SR 500mg) is an effective, well-balanced anti-diabetic medication for Type 2 Diabetes patients. Its dual mechanism ensures better glycemic control, while the sustained-release formula improves tolerance. However, proper monitoring, lifestyle modifications, and regular medical check-ups are essential for maximizing its benefits.

Before starting SEIZMET G 0.5, consult your diabetologist or healthcare provider for personalized guidance based on your medical condition.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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