Losartan (50mg), Hydrochlorothiazide (12.5mg)"

Aug 16, 2023

Introduction

LOSASTRUM H is a combination medication containing Losartan (50mg) and Hydrochlorothiazide (12.5mg), widely prescribed to manage high blood pressure (hypertension) effectively. It helps lower blood pressure, reducing the risk of heart attacks, strokes, and kidney damage. This antihypertensive combination offers dual benefits by relaxing blood vessels and eliminating excess fluid from the body, making it a preferred choice for hypertension management.

Key Ingredients

  1. Losartan (50mg):

    • Belongs to the class of angiotensin II receptor blockers (ARBs).

    • Prevents blood vessels from narrowing, ensuring smooth blood flow.

    • Reduces strain on the heart, helping to maintain healthy circulation.

  2. Hydrochlorothiazide (12.5mg):

    • A thiazide diuretic (water pill) that helps remove excess sodium and water.

    • Reduces fluid retention (edema).

    • Lowers blood pressure by decreasing blood volume.

Key Benefits

  • Effective Blood Pressure Control: Helps lower hypertension efficiently.

  • Reduces Risk of Cardiovascular Diseases: Minimizes the chances of heart attacks and strokes.

  • Combines Two Mechanisms of Action: Losartan relaxes blood vessels, while Hydrochlorothiazide removes excess fluid.

  • Protects Kidney Function: Beneficial for hypertensive patients with kidney issues.

  • Helps Manage Fluid Retention: Reduces swelling and bloating caused by excess fluid accumulation.

  • Enhances Overall Heart Health: Promotes better circulation and prevents complications.

How Does It Work?

The dual-action formula of LOSASTRUM H works effectively in hypertension management:

  1. Losartan (50mg) blocks angiotensin II receptors, preventing blood vessels from narrowing and ensuring smooth blood circulation.

  2. Hydrochlorothiazide (12.5mg) increases urine production, removing excess salt and water, thus lowering blood pressure.

  3. This combination reduces strain on the heart and kidneys, offering long-term protection against heart disease and kidney damage.

Directions for Use

  • Dosage: Take one tablet daily or as directed by a physician.

  • Best Time to Take: Preferably in the morning to prevent nighttime urination disturbances.

  • With or Without Food: Can be taken with or without meals.

  • Swallow Whole: Do not crush or chew the tablet.

  • Hydration: Drink plenty of water throughout the day.

  • Avoid Missing Doses: Consistency is crucial for effective blood pressure control.

Precautions & Warnings

  • Not Recommended in Pregnancy: May cause harm to the unborn baby.

  • Avoid Alcohol: It may increase dizziness and lower blood pressure excessively.

  • Kidney or Liver Issues: Consult your doctor before use.

  • Diabetes Patients: Should monitor blood sugar levels, as thiazide diuretics can alter glucose levels.

  • Electrolyte Imbalance: Regular blood tests are advised to monitor potassium and sodium levels.

  • Avoid Excessive Sun Exposure: Hydrochlorothiazide can increase sensitivity to sunlight.

Side Effects

Most side effects are mild and temporary. However, some patients may experience:

Common Side Effects

  • Dizziness or Lightheadedness

  • Frequent Urination

  • Fatigue or Weakness

  • Headache

  • Nausea or Vomiting

  • Dry Mouth

Serious Side Effects (Seek Medical Attention)

  • Severe Drop in Blood Pressure (Hypotension)

  • High Potassium Levels (Hyperkalemia)

  • Kidney Dysfunction

  • Severe Allergic Reactions (Swelling, Rash, Difficulty Breathing)

  • Irregular Heartbeat

Who Should Not Take LOSASTRUM H?

  • Pregnant or Breastfeeding Women

  • Patients with Severe Kidney or Liver Disorders

  • People Allergic to Losartan, Hydrochlorothiazide, or Sulfa Drugs

  • Patients with Gout (as it may increase uric acid levels)

  • Individuals with Addison’s Disease

Drug Interactions

LOSASTRUM H may interact with certain medications. Inform your doctor if you are taking:

  • NSAIDs (e.g., Ibuprofen, Naproxen): May reduce effectiveness.

  • Potassium Supplements or Salt Substitutes: Risk of high potassium levels.

  • Diabetes Medications (e.g., Metformin, Insulin): May require dosage adjustments.

  • Lithium: Increased risk of lithium toxicity.

  • Corticosteroids: Can worsen electrolyte imbalances.

  • Other Blood Pressure Medications: Risk of excessive low blood pressure.

Lifestyle and Dietary Recommendations

  • Low-Sodium Diet: Avoid processed and salty foods.

  • Increase Potassium-Rich Foods: Bananas, oranges, and spinach (unless advised otherwise).

  • Stay Hydrated: Drink plenty of water to prevent dehydration.

  • Regular Exercise: Engage in moderate physical activity.

  • Quit Smoking & Alcohol: Reduces cardiovascular risks.

  • Monitor Blood Pressure Regularly: Ensures effectiveness of the treatment.

Storage Instructions

  • Store in a cool, dry place, away from direct sunlight.

  • Keep out of reach of children and pets.

  • Do not use expired medication.

Conclusion

LOSASTRUM H is a potent combination of Losartan (50mg) and Hydrochlorothiazide (12.5mg), effectively managing hypertension and reducing the risk of cardiovascular diseases. With its dual-action mechanism, it provides effective blood pressure control while protecting the heart and kidneys. However, it should be taken under medical supervision, with regular monitoring of blood pressure and kidney function to ensure safety and efficacy.

If you are prescribed LOSASTRUM H, follow your doctor’s guidance, maintain a healthy lifestyle, and keep track of your blood pressure levels to achieve optimal results.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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