Mesalamine ER (400mg) & MESALMILE 400 : Tablet View Uses, Side Effects, Dosage, Mechanism of action...

Mesalamine ER (400mg) & MESALMILE 400 

Mesalamine (ER) 400mg, containing MESALMILE 400, is a potent medication primarily used in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. Mesalamine, also known as 5-aminosalicylic acid (5-ASA), plays a crucial role in reducing inflammation in the colon, thereby alleviating symptoms and promoting remission in patients suffering from these chronic conditions.

What is Mesalamine?

Mesalamine is an anti-inflammatory drug that targets the lining of the colon to reduce inflammation and prevent flare-ups in patients with IBD. The extended-release formulation ensures a sustained release of the medication, providing long-lasting effects and improving patient compliance.

Indications and Usage

Ulcerative Colitis

MESALMILE 400 is extensively prescribed for the management of mild to moderate ulcerative colitis. It helps in inducing remission during active flare-ups and maintaining remission to prevent future episodes. Ulcerative colitis is characterized by continuous inflammation and ulceration of the inner lining of the colon and rectum, leading to symptoms like abdominal pain, diarrhea, rectal bleeding, and an urgent need to defecate. MESALMILE 400 helps to alleviate these symptoms and improve the quality of life for patients.

Mechanism of Action

Mesalamine works by inhibiting the enzyme cyclooxygenase and blocking the production of prostaglandins and leukotrienes, which are mediators of inflammation. By reducing these inflammatory mediators, Mesalamine decreases inflammation, tissue damage, and associated symptoms in the gastrointestinal tract. The extended-release formulation ensures a consistent therapeutic effect, which is crucial for maintaining remission and preventing flare-ups.

Dosage and Administration

Recommended Dosage

The typical dosage of MESALMILE 400 for adults with mild to moderate ulcerative colitis is two 400mg tablets taken three times a day, for a total daily dose of 2400mg. Dosage may vary based on the severity of the condition and the patient's response to the treatment. 

Administration Instructions

MESALMILE 400 should be taken with or without food, as directed by the healthcare provider. It is essential to swallow the tablets whole, without crushing or chewing them, to ensure the extended-release mechanism works correctly. Patients should drink plenty of fluids while taking this medication to avoid dehydration, especially if they experience diarrhea.

Potential Side Effects

Common Side Effects

Some common side effects associated with MESALMILE 400 include:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Flatulence

However, if they persist or become bothersome, it is important to consult a healthcare provider.

Serious Side Effects

While rare, serious side effects can occur and require immediate medical attention. These include:

• Severe abdominal pain
• Chest pain
• Shortness of breath
• Blood in the stool
• Signs of liver dysfunction (e.g., yellowing of the skin or eyes, dark urine)

Precautions and Warnings

Allergies

Patients with a known allergy to Mesalamine, salicylates, or any component of MESALMILE 400 should not use this medication. It is important to inform the healthcare provider about any known allergies to avoid adverse reactions.

Kidney and Liver Function

Mesalamine can affect kidney and liver function. Patients with pre-existing kidney or liver conditions should use MESALMILE 400 with caution and under strict medical supervision. Regular monitoring of kidney and liver function may be necessary during treatment.

Pregnancy and Breastfeeding

The safety of MESALMILE 400 during pregnancy and breastfeeding has not been fully established. Pregnant or breastfeeding women should consult their healthcare provider before starting this medication to weigh the potential benefits and risks.

Drug Interactions

MESALMILE 400 can interact with other medications, potentially altering their effects. Some notable interactions include:

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Concurrent use may increase the risk of kidney damage.
• Azathioprine and 6-Mercaptopurine: There may be an increased risk of bone marrow suppression.
• Antacids: These can affect the release mechanism of the extended-release formulation.

Patients should inform their healthcare provider about all the medications they are currently taking, including over-the-counter drugs and supplements, to avoid potential interactions.

Conclusion

MESALMILE 400 is a valuable medication in the management of inflammatory bowel diseases like ulcerative colitis and Crohn's disease. Its extended-release formulation ensures sustained therapeutic effects, making it an effective option for inducing and maintaining remission. While generally well-tolerated, it is important for patients to be aware of potential side effects and interactions, and to follow their healthcare provider's instructions closely. With proper use, MESALMILE 400 can significantly improve the quality of life for individuals suffering from these chronic conditions. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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