Metoprolol Succinate 50 mg & Cilnidipine 10 mg ..

Metoprolol Succinate 50 mg & Cilnidipine 10 mg
CILINITAB M 50

Cilinitab M 50 is a combination medication that contains two active ingredients: Cilnidipine (10 mg) and Metoprolol Succinate (50 mg). This combination therapy is primarily used to manage hypertension (high blood pressure) and other cardiovascular conditions. The formulation combines two distinct mechanisms of action—one that dilates blood vessels and another that reduces the heart's workload, thereby working synergistically to lower blood pressure and reduce the risk of cardiovascular events.

Composition

• Active Ingredients:

  • Cilnidipine (10 mg): A calcium channel blocker, specifically a L-type and N-type calcium channel antagonist.
  • Metoprolol Succinate (50 mg): A beta-blocker, specifically a selective beta-1 adrenergic blocker that targets the heart.

• Excipients: Other inactive ingredients, such as binders, fillers, and coating agents, may vary depending on the manufacturer.

Mechanism of Action

1. Cilnidipine (10 mg)

   • Calcium Channel Blocker: Cilnidipine works by inhibiting the flow of calcium ions through the L-type and N-type calcium channels. This leads to relaxation of the smooth muscle in the blood vessels, causing vasodilation. The result is a reduction in peripheral vascular resistance, which helps to lower blood pressure.
   • Dual Mechanism: Cilnidipine’s unique action on both types of calcium channels makes it distinct from other calcium channel blockers. It not only reduces afterload by dilating blood vessels but also reduces the sympathetic nervous system activation, which can further help in controlling blood pressure.
   • Cardioprotective Effects: Cilnidipine may also provide protection against myocardial ischemia and reduce the risk of certain heart complications.

2. Metoprolol Succinate (50 mg)

   • Beta-1 Blocker: Metoprolol is a selective beta-1 adrenergic blocker, meaning it primarily targets the heart, reducing the effects of stress hormones (such as adrenaline) on the heart. This leads to a decrease in heart rate and the force of contraction.
   • Reduction in Heart Workload: By lowering the heart rate and reducing myocardial contractility, metoprolol reduces the heart's oxygen demand, which can help prevent chest pain (angina) and lower blood pressure. It also helps in managing heart failure symptoms by improving the heart’s efficiency.
   • Long-Acting Formulation: The succinate form of metoprolol is extended-release, ensuring a steady release of the drug throughout the day, offering a more sustained effect on heart rate and blood pressure.

Indications

Cilinitab M 50 is commonly prescribed for the treatment of:

1. Hypertension (High Blood Pressure):

   • Cilinitab M 50 is indicated for the management of high blood pressure, especially in patients who require dual therapy to achieve adequate control.

2. Chronic Heart Failure:

   • This combination medication is beneficial in managing heart failure due to its ability to lower blood pressure and reduce the workload on the heart.

3. Angina Pectoris (Chest Pain):

   • Metoprolol’s beta-blocking effect reduces chest pain by decreasing the heart's oxygen demand, while cilnidipine’s vasodilation helps in improving blood flow to the heart muscle.

4. Post-Myocardial Infarction (Heart Attack):

   • Cilinitab M 50 may be prescribed after a heart attack to improve long-term outcomes by reducing the risk of recurrent heart attacks and improving heart function.

Dosage and Administration

• Initial Dosage: The typical starting dose for adults is 1 tablet daily, which contains 10 mg of Cilnidipine and 50 mg of Metoprolol Succinate.
• Adjustments: The dose may be adjusted based on the patient's blood pressure readings and response to therapy, as determined by the healthcare provider.
• Administration: The tablet should be taken with or after food, ideally at the same time each day, to improve absorption and minimize the risk of gastrointestinal side effects. The tablet should not be crushed or chewed.

Side Effects

Like all medications, Cilinitab M 50 can cause side effects, although not everyone will experience them. The side effects can vary based on individual sensitivity to the active ingredients:

1. Common Side Effects:

   • Dizziness or lightheadedness, especially when standing up quickly (due to the blood pressure-lowering effects).
   • Fatigue or tiredness.
   • Headache.
   • Nausea or stomach discomfort.

2. Serious Side Effects:

   • Bradycardia (slow heart rate): Metoprolol may cause the heart rate to become dangerously slow in some individuals.
   • Hypotension (low blood pressure): Excessive lowering of blood pressure can cause fainting, dizziness, and shock.
   • Congestive Heart Failure: In rare cases, metoprolol can worsen heart failure symptoms, especially when used inappropriately.
   • Respiratory Issues: Beta-blockers like metoprolol can cause bronchospasm, especially in patients with a history of asthma or chronic obstructive pulmonary disease (COPD).

3. Other Potential Side Effects:

   • Sleep disturbances or vivid dreams.
   • Weight gain (due to fluid retention).
   • Cold hands and feet.

Precautions and Warnings

1. Caution in Heart Conditions:

   • Cilinitab M 50 should be used with caution in patients with pre-existing heart block, bradycardia, or heart failure. Close monitoring is necessary.

2. Liver and Kidney Function:

   • Patients with liver or kidney impairment may require a dosage adjustment, as the metabolism and excretion of both cilnidipine and metoprolol can be affected.

3. Asthma and Respiratory Conditions:

   • Metoprolol can trigger bronchospasm, making it unsuitable for individuals with asthma or other obstructive pulmonary diseases. In these cases, an alternative medication may be considered.

4. Pregnancy and Lactation:

   • Pregnancy: Cilinitab M 50 should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
   • Lactation: Both Cilnidipine and Metoprolol are excreted in breast milk, so the use of Cilinitab M 50 in breastfeeding mothers should be carefully evaluated.

5. Discontinuation:

   • Sudden discontinuation of metoprolol can cause a rebound increase in blood pressure or exacerbation of angina. It should be tapered gradually under medical supervision.

Conclusion

Cilinitab M 50, with its combination of Cilnidipine (10 mg) and Metoprolol Succinate (50 mg), is a highly effective medication for managing hypertension and certain heart conditions. By lowering blood pressure and reducing the strain on the heart, it helps prevent serious cardiovascular events. Patients using this medication should adhere to their prescribed dosage, attend regular check-ups, and consult their healthcare provider about any side effects or interactions with other medications. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline,  Sterisindia and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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