Obeticholic Acid (10mg) & OB-COLLAR 10: Uses, Side Effects, Dosage and Call to Action.

Obeticholic Acid (10mg) & OB-COLLAR 10

Obeticholic Acid (10mg), is used OB-COLLAR 10 primarily in the treatment of primary biliary cholangitis (PBC), a chronic liver disease. Obeticholic Acid is a semi-synthetic bile acid analog that helps regulate bile flow and reduce liver inflammation. This article explores the uses, benefits, dosage, side effects, and precautions associated with it.

Understanding Obeticholic Acid

What is Obeticholic Acid?

 By activating FXR, Obeticholic Acid reduces the production of bile acids in the liver and promotes their excretion, helping to alleviate cholestasis (impaired bile flow).

Uses of Obeticholic Acid

• Primary Biliary Cholangitis (PBC): Obeticholic Acid is used as a second-line treatment for PBC in adults who do not respond adequately to ursodeoxycholic acid (UDCA) or cannot tolerate it. PBC is a chronic autoimmune liver disease characterized by the destruction of the small bile ducts within the liver, leading to bile buildup and liver damage.

Benefits of Obeticholic Acid

• Reduces Liver Inflammation: Obeticholic Acid decreases bile acid production and promotes their excretion, helping to reduce liver inflammation and fibrosis.
• Improves Liver Function: The medication aids in improving liver enzyme levels, indicating better liver function.
• Slows Disease Progression: Obeticholic Acid can slow the progression of PBC, potentially delaying the need for liver transplantation.

Dosage and Administration

How to Take OB-COLLAR 10

• Dosage: The recommended starting dose of OB-COLLAR 10 is 5mg taken once daily. If the patient responds well to the initial dose and can tolerate it, the dosage may be increased to 10mg once daily after three months. It is important to follow the prescribed dosage and not to exceed the recommended amount without consulting a healthcare provider.
• Monitoring: Regular monitoring of liver function tests and other relevant parameters is essential to assess the effectiveness of the treatment and adjust the dosage if necessary.

Side Effects of Obeticholic Acid

Common Side Effects

• Pruritus (Itching): This is the most common side effect and can be severe in some patients. Itching is typically more intense during the initial stages of treatment.
• Fatigue: Some patients may experience tiredness or fatigue.
• Abdominal Pain and Discomfort: Mild to moderate abdominal pain can occur.

Serious Side Effects

• Liver-Related Issues: In rare cases, Obeticholic Acid can cause liver-related side effects, including jaundice (yellowing of the skin or eyes) and worsening liver function.
• Hypersensitivity Reactions: Though uncommon, some patients may experience allergic reactions, including rash, swelling, and difficulty breathing.

Precautions and Warnings

Before Taking OB-COLLAR 10

• Allergies: Inform your healthcare provider if you have any known allergies to Obeticholic Acid or any other components of the medication.
• Medical History: Discuss your complete medical history with your healthcare provider, especially if you have a history of liver disease, biliary obstruction, or other significant health conditions.
• Pregnancy and Breastfeeding: The safety of Obeticholic Acid during pregnancy and breastfeeding is not well established. It should be used during pregnancy only if clearly needed and prescribed by a healthcare provider.

Drug Interactions

Obeticholic Acid may interact with other medications, including:

• Bile Acid Sequestrants: These medications, such as cholestyramine, can interfere with the absorption of Obeticholic Acid. It is recommended to take Obeticholic Acid at least 4 hours before or after bile acid sequestrants.
• Warfarin: Obeticholic Acid may affect the anticoagulant effects of warfarin, necessitating close monitoring of blood clotting parameters.

Monitoring and Follow-Up

Regular follow-up with a healthcare provider is essential during the treatment with OB-COLLAR 10. This includes:

• Liver Function Tests: To monitor the effectiveness and safety of the medication.
• Routine Check-Ups: To assess overall health and detect any potential side effects early.

Managing Side Effects

Mild Side Effects

For mild side effects such as pruritus or fatigue, consider the following tips:

• Hydration: Drink plenty of water to stay hydrated, which can help alleviate some side effects.
• Moisturizers: Use skin moisturizers to help reduce itching.
• Rest: Ensure adequate rest to combat fatigue.

Conclusion

OB-COLLAR 10, containing Obeticholic Acid (10mg), is a valuable medication for managing primary biliary cholangitis, particularly for patients who do not respond to or cannot tolerate ursodeoxycholic acid. Its role in reducing liver inflammation and improving liver function makes it a critical component in the treatment of PBC. As with any medication, it is important to use OB-COLLAR 10 under the supervision of a healthcare provider, adhere to the prescribed dosage, and report any side effects promptly to ensure safe and effective treatment. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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