Obeticholic Acid (5mg) & OB-COLLAR 5 :Tablet- View Uses, Side Effects, Dosage, Mechanism of action...

Obeticholic Acid (5mg) & OB-COLLAR 5 

Obeticholic Acid (5mg), is a medication designed to OB-COLLAR 5 to treat specific liver conditions, particularly primary biliary cholangitis (PBC). As an emerging therapy, Obeticholic Acid offers hope for those suffering from chronic liver diseases, providing a new approach to managing symptoms and slowing disease progression. This article will delve into the uses, benefits, dosage, side effects, and precautions associated with it.

Understanding Obeticholic Acid

What is Obeticholic Acid?

Obeticholic Acid is a semi-synthetic bile acid analog that acts as an agonist for the farnesoid X receptor (FXR). FXR plays a crucial role in regulating bile acid synthesis, transport, and metabolism. By activating FXR, Obeticholic Acid helps reduce the production of bile acids and promote their excretion, which can alleviate the symptoms and progression of liver diseases like PBC.

Uses of Obeticholic Acid

Obeticholic Acid is primarily used for:

• Primary Biliary Cholangitis (PBC): It is prescribed for adults with PBC, especially those who have not responded adequately to ursodeoxycholic acid (UDCA) or who cannot tolerate UDCA.

How Obeticholic Acid Works

Obeticholic Acid binds to and activates FXR, a nuclear receptor involved in bile acid homeostasis. By activating FXR, Obeticholic Acid reduces the synthesis of bile acids in the liver and increases their clearance from the bloodstream. This action helps to alleviate cholestasis (bile acid buildup) and reduce liver inflammation and fibrosis.

Benefits of OB-COLLAR 5

Effective Management of PBC

• Symptom Relief: OB-COLLAR 5 helps reduce symptoms such as fatigue, itching, and jaundice in patients with PBC.
• Disease Progression: It slows the progression of liver damage, reducing the risk of cirrhosis and liver failure.
• Improved Liver Function: By reducing bile acid levels, OB-COLLAR 5 helps improve liver enzyme levels, which are markers of liver function.

Dosage and Administration

Recommended Dosage

• Starting Dose: The typical starting dose of OB-COLLAR 5 is 5mg taken once daily.
• Adjustment: Depending on the patient's response and tolerance, the dose may be increased to 10mg once daily after three months.

Administration

• With or Without Food: OB-COLLAR 5 can be taken with or without food. However, it is advisable to take it at the same time each day to maintain consistent blood levels of the medication.
• Missed Dose: If a dose is missed, it should be taken as soon as possible on the same day. 

Monitoring

• Regular Check-Ups: Regular monitoring of liver function tests and other relevant parameters is essential to assess the effectiveness and safety of the treatment.
• Dose Adjustment: Based on the liver function test results and clinical response, the healthcare provider may adjust the dosage.

Side Effects of OB-COLLAR 5

Common Side Effects

• Pruritus (Itching): This is the most common side effect and may occur during the initial phase of treatment.
• Fatigue: Some patients may experience tiredness or lack of energy.
• Abdominal Pain: Mild to moderate abdominal discomfort can occur.

Serious Side Effects

Though rare, serious side effects may include:

• Severe Pruritus: Intense itching that may require dose adjustment or additional treatment.
• Liver-Related Issues: In rare cases, worsening liver function or hepatic decompensation can occur.

Managing Side Effects

• Itching: For patients experiencing severe itching, the healthcare provider may recommend antihistamines or bile acid sequestrants.
• Dose Modification: Adjusting the dose or frequency of OB-COLLAR 5 can help manage side effects.

Precautions and Warnings

Before Taking OB-COLLAR 5

• Allergies: Inform your healthcare provider if you have any known allergies to Obeticholic Acid or any other ingredients in OB-COLLAR 5.
• Medical History: Provide a complete medical history, especially if you have a history of liver conditions, biliary obstruction, or severe hepatic impairment.

Drug Interactions

OB-COLLAR 5 may interact with other medications, including:

• Bile Acid Sequestrants: These can interfere with the absorption of Obeticholic Acid. It is recommended to take OB-COLLAR 5 at least 4-6 hours before or after taking bile acid sequestrants.
• Statins: Caution is advised when co-administering with statins due to the increased risk of liver enzyme abnormalities.

Pregnancy and Breastfeeding

• Pregnancy: The safety of Obeticholic Acid during pregnancy has not been established. It should only be used if clearly needed and prescribed by a healthcare provider.
• Breastfeeding: It is unknown if Obeticholic Acid passes into breast milk. Consult your healthcare provider before using OB-COLLAR 5 while breastfeeding.

Conclusion

OB-COLLAR 5, containing Obeticholic Acid (5mg), offers an effective treatment option for individuals with primary biliary cholangitis. By targeting FXR, it helps manage symptoms, improve liver function, and slow disease progression. Patients should follow their healthcare provider’s instructions carefully, monitor for side effects, and attend regular check-ups to ensure the best outcomes with this medication. With proper use and monitoring, OB-COLLAR 5 can significantly enhance the quality of life for those suffering from PBC. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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