PAFAGOLD M 500 Tablet- View Uses, Side Effects, Dosage, Mechanism of action...

PAFAGOLD M 500

Dapaflozin 10 mg + Metformin SR 500 mg

PAFAGOLD M 500 is a combination pharmaceutical product containing Paracetamol (500mg) and Mefenamic Acid (500mg), two medications widely used for their analgesic (pain-relieving) and antipyretic (fever-reducing) properties. This combination is particularly effective in managing pain and inflammation associated with various conditions, including headaches, dental pain, menstrual pain, musculoskeletal pain, and fever. This guide will cover all important aspects of PAFAGOLD M 500, including its uses, dosage, side effects, and precautions.

Uses of PAFAGOLD M 500

Pain Relief

• Headaches: PAFAGOLD M 500 is effective in alleviating various types of headaches, including tension headaches and migraines.
• Dental Pain: It provides relief from pain associated with dental procedures, tooth extractions, and other dental conditions.
• Menstrual Pain: PAFAGOLD M 500 is commonly used to relieve dysmenorrhea (menstrual cramps), providing significant relief from pain and discomfort.
• Musculoskeletal Pain: This medication is effective in managing pain from musculoskeletal conditions, including arthritis, sprains, and strains.

Fever Reduction

• Antipyretic Properties: Both Paracetamol and Mefenamic Acid have fever-reducing properties, making PAFAGOLD M 500 effective in lowering high body temperatures associated with infections and other illnesses.

Inflammation Reduction

• Anti-inflammatory Effects: Mefenamic Acid, a nonsteroidal anti-inflammatory drug (NSAID), helps reduce inflammation and swelling, enhancing the pain-relieving effects of Paracetamol.

Mechanism of Action

• Paracetamol: Paracetamol works by inhibiting the production of prostaglandins in the brain, which are chemicals responsible for pain and fever. It acts centrally in the brain to provide analgesic and antipyretic effects.
• Mefenamic Acid: Mefenamic Acid inhibits the enzymes cyclooxygenase (COX-1 and COX-2), which play a key role in the production of prostaglandins involved in inflammation, pain, and fever. By reducing prostaglandin synthesis, Mefenamic Acid helps alleviate pain and reduce inflammation.

Dosage and Administration

Recommended Dosage

• The standard dose of PAFAGOLD M 500 is one tablet taken up to three times daily, depending on the severity of the pain or fever and the patient's response to the medication. It is important not to exceed the recommended dose to avoid potential side effects.

Administration Guidelines

• With Food: PAFAGOLD M 500 should be taken with food to minimize gastrointestinal discomfort and reduce the risk of stomach upset.
• Consistency: Take the medication at regular intervals as prescribed by your healthcare provider to maintain consistent blood levels and achieve optimal pain and fever relief.
• Regular Monitoring: Patients should monitor their symptoms and report any persistent or worsening conditions to their healthcare provider.

Side Effects

Common Side Effects

• Gastrointestinal Issues: Common side effects include nausea, vomiting, diarrhea, and stomach pain. Taking the medication with food can help alleviate these symptoms.
• Dizziness and Drowsiness: Some patients may experience dizziness or drowsiness, which can affect their ability to perform tasks requiring alertness, such as driving.

Serious Side Effects

• Liver Damage: Overuse or long-term use of Paracetamol can cause liver damage. Patients should adhere to the recommended dosage and avoid consuming alcohol while taking PAFAGOLD M 500.
• Kidney Problems: Prolonged use of Mefenamic Acid can affect kidney function. Regular monitoring of kidney function is advised for patients on long-term therapy.
• Allergic Reactions: Rarely, patients may experience allergic reactions, including rash, itching, swelling, severe dizziness, and difficulty breathing. Immediate medical attention is required if these symptoms occur.
• Gastrointestinal Bleeding: Mefenamic Acid can increase the risk of gastrointestinal bleeding, particularly in patients with a history of ulcers or gastrointestinal disorders. Symptoms include black or bloody stools and vomiting blood.

Precautions and Warnings

Contraindications

• Allergy to Paracetamol or Mefenamic Acid: Patients with a known allergy to Paracetamol, Mefenamic Acid, or any other component of PAFAGOLD M 500 should not take this medication.
• Severe Liver or Kidney Disease: Patients with severe liver or kidney disease should avoid PAFAGOLD M 500 due to the risk of further organ damage.

Precautions

• Pregnancy and Breastfeeding: PAFAGOLD M 500 should be used with caution during pregnancy and breastfeeding. It is essential to consult a healthcare provider before use.
• Concurrent Medications: Patients should inform their healthcare provider about all medications they are taking, as PAFAGOLD M 500 can interact with other drugs, particularly other NSAIDs and anticoagulants.

Drug Interactions

Medications to Avoid

• Other NSAIDs: Combining PAFAGOLD M 500 with other NSAIDs can increase the risk of gastrointestinal bleeding and kidney damage.
• Anticoagulants: Concurrent use with anticoagulants (e.g., warfarin) can increase the risk of bleeding. Patients should be closely monitored for signs of bleeding.
• Alcohol: Consuming alcohol while taking PAFAGOLD M 500 can increase the risk of liver damage and gastrointestinal side effects.

Monitoring Required

• Liver Function Tests: Regular liver function tests are recommended for patients on long-term therapy to monitor for potential liver damage.
• Kidney Function Tests: Periodic kidney function tests help detect any potential renal-related side effects early.

Patient Management

Lifestyle Modifications

• Dietary Considerations: Patients should maintain a balanced diet and take PAFAGOLD M 500 with food to minimize gastrointestinal discomfort.
• Hydration: Staying well-hydrated is important, especially for patients taking NSAIDs, to support kidney function.
• Avoiding Alcohol: Patients should avoid alcohol consumption to reduce the risk of liver damage and gastrointestinal issues.

Regular Follow-Ups

• Medical Appointments: Regular check-ups with a healthcare provider are crucial to monitor the effectiveness of PAFAGOLD M 500 and adjust the treatment plan as necessary.
• Blood Tests: Periodic blood tests, including liver and kidney function tests, are essential to monitor the patient's response to the medication and detect any potential side effects early.

Conclusion

PAFAGOLD M 500 is an effective combination medication for managing pain, inflammation, and fever associated with various conditions. By leveraging the complementary actions of Paracetamol and Mefenamic Acid, it provides significant relief from discomfort and improves quality of life. While there are potential side effects and precautions to consider, regular monitoring and adherence to prescribed dosages can help manage these risks. Patients taking PAFAGOLD M 500 should maintain open communication with their healthcare providers to ensure optimal treatment outcomes and address any concerns promptly. Understanding the uses, side effects, and precautions associated with PAFAGOLD M 500 allows patients to manage their condition more effectively and improve their quality of life. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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