SAVELINER 800 & Sevelamer (800mg).:Tablet- Uses, Side Effects, Dosage, Mechanism of action and more.....

SAVELINER 800 

Sevelamer (800mg)

SAVELINER 800 is a pharmaceutical product containing Sevelamer 800mg, primarily used to control serum phosphorus levels in patients with chronic kidney disease (CKD) on dialysis.  By binding dietary phosphorus in the gastrointestinal tract, SAVELINER 800 effectively reduces the absorption of phosphorus, thereby maintaining balanced mineral levels in the body.

Uses of SAVELINER 800

SAVELINER 800 is indicated for:

1. Management of Hyperphosphatemia in CKD Patients: SAVELINER 800 is extensively used to manage high phosphorus levels in patients undergoing hemodialysis or peritoneal dialysis.
2. Prevention of Bone Disorders: By controlling phosphorus levels, SAVELINER 800 helps prevent renal osteodystrophy and other bone disorders associated with chronic kidney disease.
3. Reduction of Cardiovascular Risk: Hyperphosphatemia is linked to an increased risk of cardiovascular diseases in CKD patients. SAVELINER 800 helps mitigate this risk by maintaining optimal phosphorus levels.

Mechanism of Action

SAVELINER 800 contains Sevelamer hydrochloride, which binds to dietary phosphorus in the gastrointestinal tract. This binding process forms an insoluble complex that is excreted in the feces, thus reducing the amount of phosphorus absorbed into the bloodstream. By lowering serum phosphorus levels, SAVELINER 800 helps prevent the complications associated with hyperphosphatemia, such as vascular calcification and secondary hyperparathyroidism.

Dosage and Administration

Initial Dose

For adults and children over 6 years old, the recommended initial dose of SAVELINER 800 varies based on the patient's serum phosphorus levels:

• Serum phosphorus > 5.5 and < 7.5 mg/dL: 800 mg three times daily with meals.
• Serum phosphorus ≥ 7.5 and < 9.0 mg/dL: 1,600 mg three times daily with meals.
• Serum phosphorus ≥ 9.0 mg/dL: 1,600 mg three times daily with meals.

Maintenance Dose

The dosage of SAVELINER 800 should be adjusted based on the patient's serum phosphorus levels. Regular monitoring is essential to determine the effective maintenance dose, which typically ranges between 800 mg and 1,600 mg three times daily with meals.

How to Take SAVELINER 800

• With Meals: SAVELINER 800 should be taken with meals to effectively bind dietary phosphorus.
• Swallow Whole: Do not crush, chew, or break the tablet. Swallow it whole with water.

Side Effects of SAVELINER 800

Like any medication, SAVELINER 800 can cause side effects. Common side effects include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, constipation, and abdominal pain are commonly reported.
• Metabolic Effects: There may be instances of metabolic acidosis, particularly in patients with pre-existing metabolic conditions.
• Vitamin Deficiency: Long-term use of SAVELINER 800 may reduce the absorption of fat-soluble vitamins (A, D, E, and K) and folic acid. Monitoring and supplementation may be necessary.

Serious Side Effects

• Severe Allergic Reactions: Rash, itching, swelling, severe dizziness, and trouble breathing.
• Intestinal Obstruction: Severe abdominal pain, bloating, and constipation may indicate an intestinal blockage.

Precautions and Warnings

• Medical History: Inform your healthcare provider about any history of bowel obstruction, swallowing disorders, or severe constipation.
• Pregnancy and Breastfeeding: The safety of SAVELINER 800 during pregnancy and breastfeeding is not well established. Consult your healthcare provider before use.
• Drug Interactions: SAVELINER 800 can interact with other medications, affecting their absorption. 

Drug Interactions

• Antiarrhythmics: Reduced absorption of antiarrhythmic drugs such as amiodarone.
• Antiseizure Medications: Reduced efficacy of antiseizure drugs like phenytoin.
• Thyroid Hormones: Decreased absorption of thyroid hormones, necessitating dosage adjustments.

Monitoring and Laboratory Tests

Regular monitoring of serum phosphorus levels is crucial to determine the effectiveness of SAVELINER 800 and to adjust the dosage as needed. Additionally, monitoring calcium, bicarbonate, and parathyroid hormone levels is recommended to manage CKD-related complications effectively.

Lifestyle and Dietary Recommendations

To enhance the effectiveness of SAVELINER 800, patients should adhere to dietary and lifestyle recommendations:

• Phosphorus-Restricted Diet: Limit the intake of high-phosphorus foods such as dairy products, nuts, seeds, and processed foods.
• Hydration: Maintain adequate hydration to support kidney function and overall health.
• Regular Exercise: Engage in regular physical activity to improve overall well-being and manage CKD symptoms.

Conclusion

SAVELINER 800 is a vital medication for managing hyperphosphatemia in patients with chronic kidney disease on dialysis. By effectively controlling serum phosphorus levels, SAVELINER 800 helps prevent complications such as bone disorders and cardiovascular diseases. Adhering to the prescribed dosage, monitoring phosphorus levels, and following dietary recommendations can significantly enhance the quality of life for CKD patients. Always consult your healthcare provider before starting or adjusting the dosage of SAVELINER 800 to ensure safe and effective use.Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology.

For further information 

Email: info@sterispharma.com /  contact@sterispharma.com

Call/WhatsApp:  7877551268, 7849827488 

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