Sevelamer 400 mg Tablet: View Uses, Benefits, Dosage & Side Effects.

Sevelamer 400 mg tablet is a phosphate binder commonly prescribed to individuals with chronic kidney disease (CKD), especially those on dialysis, to help manage and control elevated phosphate levels in the blood. Proper phosphate management is critical in patients with impaired kidney function, as high phosphate levels can lead to bone and cardiovascular complications. Sevelamer is used to manage elevated blood phosphorus levels in dialysis patients with chronic renal disease. This guide will help you understand everything about Sevelamer 400 mg – its uses, benefits, dosage guidelines, precautions, and possible side effects.  

What is Sevelamer 400 mg Tablet?

Sevelamer is a non-absorbable phosphate binder, available in tablet form, typically in 400 mg and 800 mg strengths. Unlike calcium-based phosphate binders, Sevelamer does not contribute to calcium overload in the body. It works by binding with phosphate in the digestive tract, reducing its absorption into the bloodstream. 

Sevelamer 400 mg Tablet: Uses

Sevelamer is primarily used in the treatment of:

1. Hyperphosphatemia in Chronic Kidney Disease (CKD)

• Patients with CKD, especially those undergoing hemodialysis or peritoneal dialysis, often experience elevated levels of phosphate in the blood.

• High phosphate levels can lead to bone weakening, calcification of blood vessels, and other complications.

• Sevelamer helps reduce serum phosphate levels by binding to phosphate in food during digestion.

2. Prevention of Renal Bone Disease

• Sevelamer helps prevent bone disease associated with kidney failure by lowering phosphate levels and maintaining a proper balance of minerals in the body. 

How Sevelamer Works

After oral administration, Sevelamer Tablet binds to dietary phosphate in the gut and forms an insoluble complex. This complex is not absorbed into the bloodstream and is excreted in the feces. This mechanism helps lower serum phosphate levels without causing a rise in calcium or aluminum levels in the body. 

Key Benefits of Sevelamer 400 mg Tablet

1. Reduces Phosphate Levels Without Increasing Calcium

   • Unlike other phosphate binders such as calcium acetate, Sevelamer does not increase calcium levels in the blood.

2. Cardiovascular Protection

   • High phosphate levels are linked to vascular calcification and cardiovascular disease in CKD patients. By reducing phosphate, Sevelamer may reduce this risk.

3. Lowers LDL Cholesterol

   • Sevelamer has been shown to reduce LDL (bad) cholesterol levels in some patients.

4. Improves Bone Health

   • Helps prevent mineral and bone disorders in dialysis patients by reducing phosphate load.

Sevelamer 400 mg Dosage Guidelines

The dosage of Sevelamer should always be determined by a healthcare professional based on individual patient needs, serum phosphate levels, and dietary phosphate intake.

General Dosage Recommendations:

• Initial Dose: Typically ranges from 800 to 1600 mg three times a day with meals.

• Maintenance Dose: Adjusted based on serum phosphate levels.

Important Instructions:

• Take with Meals: Sevelamer should always be taken with food to effectively bind dietary phosphate.

• Do Not Crush or Chew: Tablets should be swallowed whole.

• Hydration: Drink plenty of fluids unless advised otherwise by your doctor. 

Sevelamer 400 mg Side Effects

Sevelamer is generally well-tolerated, but some patients may experience side effects.

Common Side Effects:

• Nausea

• Vomiting

• Constipation

• Diarrhea

• Abdominal pain

• Flatulence

Less Common but Serious Side Effects:

• Bowel obstruction

• Gastrointestinal perforation

• Fecal impaction

• Hypophosphatemia (low phosphate levels)

If you experience severe abdominal pain, persistent constipation, or signs of intestinal blockage, seek medical help immediately. 

Precautions and Warnings

• Pregnancy and Breastfeeding: Consult your doctor before taking Sevelamer if you are pregnant or nursing. 

• Gastrointestinal Disorders: Not recommended in patients with bowel obstruction or severe digestive tract disorders.

• Drug Interactions: Sevelamer may reduce the absorption of some medications, such as ciprofloxacin, thyroid supplements, and certain anti-epileptic drugs. Take other medications at least 1 hour before or 3 hours after Sevelamer.

Sevelamer 400 mg Price and Availability

The price of Sevelamer 400 mg may vary depending on the brand and location. It is available in most medical stores and online pharmacies. On average, the cost can range from ₹60 to ₹150 per tablet depending on the manufacturer and pack size. 

Why Choose Sevelamer 400 mg Tablet From Steris Healthcare?

Sevelamer 400 mg Tablet from Steris Healthcare stands out as a trusted solution for managing elevated phosphate levels in patients with chronic kidney disease (CKD), particularly those undergoing dialysis. At Steris Healthcare, we prioritize quality, efficacy, and patient safety in every formulation — and Sevelamer 400 mg is no exception. Manufactured under stringent quality standards and GMP-certified facilities, this phosphate binder helps prevent complications like bone damage and heart issues caused by hyperphosphatemia.

One of the key advantages of choosing Sevelamer from Steris Healthcare is the reliable bioavailability and minimal systemic absorption, ensuring it acts locally in the gut to bind phosphate effectively without affecting other bodily functions. Our product does not contain calcium or metal-based binders, which helps reduce the risk of vascular calcification.

Steris Healthcare also ensures cost-effectiveness and availability, making it easier for patients and healthcare providers to maintain consistent therapy. Backed by clinical research, medical guidance, and pharmacist support, our Sevelamer 400 mg tablet offers peace of mind to both prescribers and users.