sitagliptin phosphate metformin hydrochloride

Introduction

GLISITAPTIN 50 is a pharmaceutical formulation containing Sitagliptin Phosphate (50mg), a potent oral medication used in the management of Type 2 Diabetes Mellitus (T2DM). It belongs to the Dipeptidyl Peptidase-4 (DPP-4) inhibitor class, which enhances the body's ability to regulate blood sugar levels effectively. Sitagliptin Phosphate is widely prescribed to improve glycemic control in adults, either as monotherapy or in combination with other antidiabetic medications.

Key Ingredients

• Sitagliptin Phosphate (50mg) – A DPP-4 inhibitor that increases insulin secretion and reduces glucagon levels in response to meals.

How Does GLISITAPTIN 50 Work?

Sitagliptin Phosphate (50mg) functions by inhibiting the DPP-4 enzyme, which is responsible for breaking down incretin hormones like GLP-1 (Glucagon-like peptide-1) and GIP (Gastric inhibitory polypeptide). These hormones play a crucial role in:

• Stimulating insulin release from the pancreas after meals.

• Suppressing excessive glucagon secretion, thereby preventing unwanted glucose production by the liver.

• Improving beta-cell function in the pancreas over time.

• Helping maintain a steady blood glucose level throughout the day.

Uses of GLISITAPTIN 50

GLISITAPTIN 50 is indicated for:

• Type 2 Diabetes Mellitus (T2DM) as an adjunct to diet and exercise.

• Monotherapy in patients who cannot tolerate or do not respond to metformin.

• Combination therapy with Metformin, Sulfonylureas, Insulin, or SGLT2 inhibitors to achieve optimal glycemic control.

• Reduction of HbA1c levels and improvement in overall metabolic health.

Dosage and Administration

• Standard Dosage: One tablet of GLISITAPTIN 50 (containing Sitagliptin Phosphate 50mg) once daily.

• With Metformin: Typically combined with Metformin SR for enhanced glycemic control.

• With Insulin or Sulfonylureas: Dosage adjustments may be required to prevent hypoglycemia.

• Renal Impairment: Dosage should be reduced in patients with moderate to severe kidney dysfunction.

Key Benefits of GLISITAPTIN 50

• Effectively lowers blood sugar levels by enhancing the body's natural insulin response.

• Reduces postprandial glucose spikes, leading to better long-term glucose control.

• Weight-neutral medication, making it suitable for overweight individuals with diabetes.

• Lower risk of hypoglycemia compared to sulfonylureas or insulin.

• Improves pancreatic beta-cell function and enhances insulin sensitivity.

Side Effects of GLISITAPTIN 50

While Sitagliptin Phosphate (50mg) is well-tolerated, some individuals may experience:

• Mild gastrointestinal discomfort (nausea, diarrhea, or bloating).

• Headache or dizziness.

• Upper respiratory tract infections (common cold, sore throat).

• Hypoglycemia, especially when used with insulin or sulfonylureas.

• Pancreatitis (rare but serious; symptoms include severe abdominal pain).

• Allergic reactions, such as rashes or swelling.

Precautions and Warnings

• Not recommended for Type 1 Diabetes or Diabetic Ketoacidosis (DKA).

• Patients with renal impairment should undergo kidney function tests before starting therapy.

• Monitor liver function if combined with hepatically metabolized drugs.

• Use with caution during pregnancy and lactation (consult a healthcare provider before use).

• Patients with a history of pancreatitis should use with caution.

Drug Interactions

GLISITAPTIN 50 may interact with:

• Insulin or Sulfonylureas – Increased risk of hypoglycemia.

• CYP3A4 Inhibitors – Potential alteration in drug metabolism.

• Digoxin – May slightly increase digoxin levels; monitoring is advised.

• ACE Inhibitors – Possible increased risk of angioedema.

Price and Availability in India

The Price of GLISITAPTIN 50 varies based on the manufacturer and pharmacy location. In India, the price typically ranges between ₹250 – ₹500 per strip of 10 tablets. It is available in leading pharmacies and can also be purchased through licensed online medical stores.

Conclusion

GLISITAPTIN 50 (Sitagliptin Phosphate 50mg) is an effective DPP-4 inhibitor for managing Type 2 Diabetes Mellitus. Its ability to enhance insulin secretion, suppress glucagon release, and improve glucose metabolism makes it a preferred choice for many diabetic patients. With low risk of hypoglycemia, weight neutrality, and significant HbA1c reduction, GLISITAPTIN 50 offers a well-balanced treatment approach for individuals seeking better glycemic control. However, it is essential to follow medical guidance to optimize benefits while minimizing risks.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW