Sitagliptin Phosphate Tablets IP 50mg

Introduction

ST-GLIPTIN 50 contains Sitagliptin (50mg), a widely used oral medication for the management of type 2 diabetes mellitus (T2DM). It belongs to the class of drugs known as Dipeptidyl Peptidase-4 (DPP-4) inhibitors, which help regulate blood sugar levels by enhancing the body's natural insulin production. Sitagliptin is effective in controlling blood glucose levels when used alongside a proper diet and exercise regimen.

Key Ingredients

Sitagliptin (50mg)

• DPP-4 Inhibitor: Works by blocking the action of DPP-4 enzymes, which degrade incretin hormones.

• Increases Insulin Secretion: Helps the pancreas release more insulin when blood sugar levels are high.

• Reduces Glucagon Production: Lowers the amount of sugar produced by the liver, thereby controlling blood glucose levels.

• Supports Beta-Cell Function: Protects insulin-producing beta cells in the pancreas.

Key Benefits

1. Effective Glycemic Control

   • Lowers fasting and postprandial blood glucose levels.

   • Enhances insulin sensitivity.

2. Weight-Neutral Medication

   • Unlike some other diabetes medications, Sitagliptin does not contribute to weight gain.

3. Low Risk of Hypoglycemia

   • Works in a glucose-dependent manner, reducing the risk of dangerously low blood sugar levels.

4. Combination-Friendly

   • Can be used alone or in combination with other antidiabetic drugs, such as Metformin, Sulfonylureas, or Insulin.

5. Cardiovascular Benefits

   • Some studies suggest that Sitagliptin may have a neutral or slightly beneficial effect on cardiovascular health.

6. Improved Beta-Cell Function

   • Helps preserve pancreatic function, leading to long-term blood sugar control.

How Does ST-GLIPTIN 50 Work?

Sitagliptin functions by targeting the incretin system in the body, which plays a crucial role in blood sugar regulation:

• Increases GLP-1 and GIP Levels: These hormones enhance insulin secretion in response to meals.

• Decreases Glucagon Secretion: Glucagon signals the liver to produce glucose; Sitagliptin helps suppress this effect.

• Enhances Insulin Sensitivity: It improves the body's ability to use insulin more effectively.

Indications & Uses

ST-GLIPTIN 50 is prescribed for patients with Type 2 Diabetes Mellitus who require better blood sugar control. It is commonly used in:

• Monotherapy: When diet and exercise alone are insufficient.

• Combination Therapy: Alongside Metformin, Sulfonylureas, or Insulin.

• Patients with Renal Impairment: Dose adjustments may be required based on kidney function.

Dosage & Administration

• Standard Dosage: 50mg once daily, usually taken with or without food.

• In Combination Therapy: Dose adjustments may be needed depending on the additional medications prescribed.

• For Patients with Kidney Disease: Lower doses may be recommended based on renal function.

• Missed Dose: If a dose is missed, take it as soon as possible. Do not double the dose to compensate.

Side Effects

While ST-GLIPTIN 50 is generally well-tolerated, some common side effects include:

Mild Side Effects

• Headache

• Upper respiratory tract infections (e.g., nasal congestion, sore throat)

• Stomach discomfort

• Mild nausea

Serious Side Effects (Rare)

• Pancreatitis: Severe abdominal pain, vomiting.

• Severe Allergic Reactions: Skin rash, swelling, or difficulty breathing.

• Joint Pain: Persistent or severe pain in the joints.

• Kidney Dysfunction: Worsening renal function in some cases.

Precautions & Warnings

1. Patients with Kidney Disease: Dose adjustments are necessary for those with impaired kidney function.

2. Risk of Pancreatitis: Monitor for signs of pancreatitis and discontinue use if symptoms occur.

3. Pregnancy & Breastfeeding: Consult a doctor before use during pregnancy or lactation.

4. Liver Disorders: Patients with liver disease should take extra precautions when using Sitagliptin.

5. Hypoglycemia Risk: While Sitagliptin alone does not cause hypoglycemia, the risk may increase when combined with Sulfonylureas or Insulin.

Drug Interactions

ST-GLIPTIN 50 may interact with certain medications, including:

• Insulin or Sulfonylureas: Increased risk of hypoglycemia.

• Digoxin: May increase digoxin blood levels.

• Corticosteroids & Diuretics: Can increase blood sugar levels, potentially reducing Sitagliptin’s effectiveness.

• ACE Inhibitors: Increased risk of angioedema (swelling of the face, lips, or throat).

Who Should Avoid ST-GLIPTIN 50?

• Patients with Type 1 Diabetes

• Individuals with a history of pancreatitis

• Severe kidney or liver disease patients

• Those with a known allergy to Sitagliptin or any of its components

Storage Instructions

• Store at room temperature (15°C - 30°C).

• Keep away from direct sunlight and moisture.

• Keep out of reach of children.

Price & Availability in India

The Sitagliptin 50mg price may vary depending on the brand and region. In India, the approximate cost ranges from ₹200 to ₹500 per strip of 10 tablets. However, it is advisable to check with local pharmacies or online stores for the latest pricing.

Conclusion

ST-GLIPTIN 50 (Sitagliptin 50mg) is a powerful and effective medication for managing Type 2 Diabetes Mellitus. It provides significant blood sugar control with minimal side effects and is weight-neutral, making it a preferred choice for many diabetic patients. When used appropriately under medical supervision, Sitagliptin can improve glycemic control, pancreatic function, and overall quality of life.

For best results, patients should combine ST-GLIPTIN 50 with a healthy diet, regular exercise, and routine blood sugar monitoring. Always consult your doctor before starting any new medication or altering your diabetes treatment plan.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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