Ambrisentan 5 mg Uses: A Complete Guide for Pulmonary Hypertension Patients

Ambrisentan is a revolutionary medication used to treat pulmonary arterial hypertension (PAH)—a condition that significantly impacts a patient's breathing and overall heart health. If you're exploring the best options to manage PAH, look no further than AMBRISTAR 5, the trusted brand from Steris Healthcare. With proven results and high patient satisfaction, this guide will walk you through everything you need to know—from ambrisentan 5 mg uses to the ambrisentan mechanism of action, ambrisentan 10 mg alternatives, price, side effects, and much more.

 Understanding Pulmonary Arterial Hypertension (PAH)

PAH is a progressive disorder characterized by high blood pressure in the arteries that supply the lungs. This results in:

• Shortness of breath

• Fatigue

• Chest pain

• Lightheadedness

• Heart failure, if left untreated

Ambrisentan, by selectively blocking the endothelin-A receptor, is one of the most effective medications to halt the progression of PAH and enhance patients' quality of life.

 What is AMBRISTAR 5?

AMBRISTAR 5 contains Ambrisentan 5 mg and is marketed by Steris Healthcare, a company known for manufacturing quality-driven, affordable pharmaceuticals.

 Highlights:

• Selective endothelin-A receptor antagonist

• Oral, once-daily dosing

• Available in 5 mg and 10 mg strengths

• Proven to improve exercise capacity and slow disease progression

 Ambrisentan 5 mg Uses

 Approved Indications:

• Pulmonary Arterial Hypertension (WHO Group 1) in adults

• Can be used as monotherapy or in combination with other PAH therapies (e.g., phosphodiesterase-5 inhibitors)

 Other Off-label Investigations:

• Raynaud’s Phenomenon

• Scleroderma-associated complications

Please note, off-label uses should only be explored under strict medical supervision.

 Clinical Studies on Ambrisentan

Numerous clinical trials support the efficacy of Ambrisentan, including the ARIES-1 and ARIES-2 studies.

 Key Results:

• Significantly improved 6-minute walk distance (6MWD)

• Reduced symptoms of dyspnea and fatigue

• Lowered risk of PAH-related hospitalization

• Better tolerability compared to non-selective endothelin receptor antagonists

These studies confirm the clinical superiority and safety profile of Ambrisentan, making AMBRISTAR 5 a preferred choice in PAH therapy.

 Ambrisentan Mechanism of Action

The mechanism of action of Ambrisentan lies in its selective inhibition of the endothelin-A (ETA) receptor:

• Endothelin-1 causes blood vessels to narrow.

• By blocking ETA, Ambrisentan promotes vasodilation, especially in pulmonary arteries.

• It also reduces smooth muscle cell proliferation, a major contributor to PAH progression.

This targeted approach leads to enhanced pulmonary circulation, improved oxygenation, and reduced cardiac stress.

 Ambrisentan Dosage Guidelines

AMBRISTAR comes in two strengths:

• AMBRISTAR 5 (5 mg Ambrisentan)

• AMBRISTAR 10 (10 mg Ambrisentan)

 Initial Dosage:

Start with 5 mg once daily with or without food.

 Maintenance Dosage:

Increase to 10 mg once daily after 4 weeks if well-tolerated.

 Dosage Adjustments:

• In hepatic impairment: Avoid use

• In renal impairment: Use with caution

• Avoid co-administration with cyclosporine A unless adjusted

 Precautions & Warnings

• Pregnancy Category X – Strictly contraindicated. Use reliable contraception.

• May cause liver enzyme elevations – Regular liver function monitoring is advised.

• Fluid retention is possible – Monitor weight and signs of swelling.

• Avoid in patients with severe hepatic dysfunction.

 Drug Interactions

 Notable Interactions:

• Cyclosporine A – Requires dose adjustment

• Rifampin – May reduce Ambrisentan levels

• Hormonal contraceptives – Effectiveness may be altered; use additional contraception

• Avoid combining with strong CYP and OATP inhibitors unless clinically justified

 Storage Information

• Store below 30°C

• Keep in original packaging

• Protect from moisture and light

• Keep out of reach of children

 Ambrisentan 5 mg Price in India

The ambrisentan 5 mg price in India is competitive and accessible, especially through Steris Healthcare’s hospital and pharmacy distribution channels.

 Average Retail Price:

• ₹1700 – ₹2200 for a pack of 10 tablets (may vary by region and distributor)

Bulk supply and hospital pricing options are available for medical institutions.

 Patient Testimonials – What They Say About AMBRISTAR 5

 “After starting AMBRISTAR 5, my breathing improved within a month. I feel more active and energetic!” – Rekha P., Delhi

 “Steris Healthcare has made this vital medication affordable and available. Thank you for AMBRISTAR!” – Mahesh V., Mumbai

 “No side effects and significant improvement. This is a life-saving medication.” – Dr. R. Iyer, Cardiologist, Chennai

 FAQs – Frequently Asked Questions

1. What is the brand name for Ambrisentan 5 mg in India?

AMBRISTAR 5 by Steris Healthcare is a top-quality formulation of Ambrisentan 5 mg.

2. What is Ambrisentan 10 mg used for?

Ambrisentan 10 mg is used for patients who have tolerated the 5 mg dose and need enhanced efficacy in PAH management.

3. Can I take Ambrisentan long-term?

Yes, under medical supervision. Regular monitoring is essential.

4. Is AMBRISTAR 5 available over-the-counter?

No. It requires a doctor's prescription due to its potent effects and side effect profile.

5. Can Ambrisentan be taken with food?

Yes. It can be taken with or without food.

6. Is Ambrisentan safe for elderly patients?

Yes, but requires cautious dose initiation and regular follow-up.

 Call to Action – Breathe Better with AMBRISTAR 5

 Ready to take control of pulmonary arterial hypertension?
Ask your doctor about AMBRISTAR 5, a trusted product from Steris Healthcare.
 Healthcare Professionals & Hospitals – Contact Steris Healthcare for bulk orders, medical queries, and collaborations.

 Customer Helpline: +91-8209542042
 Website: www.sterishealthcare.com

 Why Choose Steris Healthcare?

Steris Healthcare stands tall in the pharmaceutical industry due to:

 GMP-certified manufacturing plants
 Stringent quality assurance practices
 Affordable medication portfolio
 Timely supply chain and nationwide reach
 Trusted by thousands of doctors and patients across India

With a vision to provide science-backed, accessible, and ethical care, Steris Healthcare remains committed to excellence.

 Conclusion

In conclusion, Ambrisentan plays a critical role in managing and treating pulmonary arterial hypertension, offering relief, hope, and longevity to patients. AMBRISTAR 5, the flagship brand by Steris Healthcare, ensures that this treatment is not only clinically effective but also affordable and trusted by healthcare professionals. From understanding ambrisentan 5 mg uses, dosage, side effects, to the ambrisentan mechanism of action, this guide has empowered you with all the essential knowledge.

Take a step toward better breathing and improved quality of life with AMBRISTAR 5—because your lungs deserve the best.