Amiodarone (200mg) & AMIDRONE 200 Mg : Steris Healthcare PVT LTD

AMIDRONE 200 Mg

Amiodarone (200mg)

Amiodarone 200 mg is a potent antiarrhythmic medication widely used in the management of various types of cardiac arrhythmias. It is particularly effective in treating ventricular tachycardia, ventricular fibrillation, and atrial fibrillation. As a medication, it plays a crucial role in stabilizing the heart rhythm and preventing life-threatening cardiac conditions.

Uses

Amiodarone 200 mg is primarily indicated for:

1. Ventricular Tachycardia (VT): A rapid heart rate that originates from the lower chambers of the heart.
2. Ventricular Fibrillation (VF): A chaotic heart rhythm that can lead to sudden cardiac arrest if not treated promptly.
3. Atrial Fibrillation (AF): An irregular and often rapid heart rate originating from the upper chambers of the heart.
4. Supraventricular Tachycardia (SVT): A faster than normal heart rate that originates above the heart's ventricles.
5. Arrhythmia Prevention Post-Surgery: To prevent arrhythmias after cardiac surgery.

Dosage

The dosage of Amiodarone 200 mg varies depending on the condition being treated and the patient's response to therapy. It is critical to follow a healthcare provider's instructions precisely. Typical dosages include:

1. Loading Dose: An initial higher dose is often given to achieve a therapeutic level quickly. This might involve 800-1600 mg per day for 1-3 weeks.
2. Maintenance Dose: Once the desired effect is achieved, the dose is gradually reduced to a maintenance dose, usually 200-400 mg per day.

Amiodarone should be taken with food to enhance absorption and reduce stomach upset. Regular monitoring of heart function and blood levels is essential to adjust the dosage appropriately.

Side Effects

While Amiodarone 200 mg is effective in managing arrhythmias, it can have several side effects due to its complex pharmacological profile:

1. Cardiovascular: Bradycardia (slow heart rate), hypotension (low blood pressure), and exacerbation of arrhythmias.
2. Pulmonary: Pulmonary toxicity, including interstitial pneumonitis and pulmonary fibrosis, which can be life-threatening.
3. Thyroid: Hyperthyroidism or hypothyroidism due to the iodine content in amiodarone.
4. Hepatic: Elevation of liver enzymes, hepatitis, and liver failure.
5. Ophthalmic: Corneal microdeposits, visual disturbances, and optic neuropathy.
6. Dermatologic: Photosensitivity, blue-gray skin discoloration, and rash.
7. Gastrointestinal: Nausea, vomiting, and constipation.
8. Neurological: Peripheral neuropathy, tremor, and ataxia.

Precautions

Due to the potential for severe side effects, precautions are crucial when taking Amiodarone 200 mg:

1. Regular Monitoring: Frequent monitoring of heart rate, liver function, thyroid function, and pulmonary status.
2. Avoid Grapefruit Juice: Grapefruit juice can increase the levels of amiodarone in the blood, leading to toxicity.
3. Sun Protection: Use sunscreen and wear protective clothing to prevent photosensitivity reactions.
4. Inform Healthcare Providers: Always inform doctors about amiodarone use before any surgical procedure or new medication.
5. Contraindications: Amiodarone is contraindicated in patients with severe sinus-node dysfunction, second- or third-degree atrioventricular block, and a history of amiodarone-induced pulmonary toxicity.
6. Pregnancy and Breastfeeding: Amiodarone should be avoided during pregnancy and breastfeeding due to potential harm to the fetus or infant.

Drug Interactions

Amiodarone 200 mg can interact with various medications, which may alter its effectiveness or increase the risk of adverse effects. Notable interactions include:

1. Antiarrhythmics: Increased risk of arrhythmias.
2. Warfarin: Enhanced anticoagulant effect, necessitating close monitoring of INR.
3. Statins: Increased risk of muscle toxicity.
4. Beta-blockers and Calcium Channel Blockers: Additive effects on heart rate and blood pressure.
5. Digoxin: Increased levels of digoxin, leading to toxicity.

Conclusion

Amiodarone 200 mg is a vital medication in the management of severe arrhythmias. Its efficacy in controlling life-threatening cardiac conditions makes it indispensable in clinical practice. However, due to its extensive side effect profile and potential for severe interactions, it must be used under strict medical supervision. Regular monitoring and adherence to prescribed dosages are essential to maximize benefits and minimize risks. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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