Dapaflozin 10 mg + Metformin SR 500 mg

Introduction

GLIDAPAFLOZIN M 10/500 is an advanced oral medication for managing type 2 diabetes mellitus (T2DM). It contains a combination of Dapagliflozin (10mg) and Metformin (500mg) SR (Sustained Release), which work synergistically to control blood sugar levels, improve insulin sensitivity, and promote overall metabolic health. This medication is prescribed to individuals struggling with poor glycemic control despite diet and exercise modifications.

Key Ingredients

1. Dapagliflozin (10mg)

• Class: Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor

• Function: Reduces blood glucose by promoting glucose excretion through urine.

• Additional Benefits: Aids in weight loss, improves cardiovascular health, and reduces blood pressure.

2. Metformin SR (500mg)

• Class: Biguanide

• Function: Reduces glucose production in the liver and enhances insulin sensitivity.

• Additional Benefits: Helps in weight management and lowers bad cholesterol (LDL levels).

How Does It Work?

GLIDAPAFLOZIN M 10/500 works through dual-action mechanisms:

1. Dapagliflozin (SGLT2 Inhibitor)

   • Prevents glucose reabsorption in the kidneys.

   • Increases glucose excretion via urine.

   • Enhances insulin function by reducing blood sugar spikes.

2. Metformin (Biguanide)

   • Suppresses excess glucose production in the liver.

   • Improves muscle glucose uptake and utilization.

   • Lowers fasting and postprandial (after meal) glucose levels.

By combining these two agents, GLIDAPAFLOZIN M 10/500 ensures steady and effective glucose regulation throughout the day.

Key Benefits

• Effective Blood Sugar Control: Lowers HbA1c levels, reducing the risk of diabetes-related complications.

• Supports Weight Loss: Dapagliflozin promotes caloric loss through urine, leading to weight reduction.

• Cardiovascular Protection: Reduces risks of heart failure and hypertension.

• Enhanced Insulin Sensitivity: Helps cells utilize glucose efficiently, preventing insulin resistance.

• Sustained Release Mechanism: Ensures consistent drug action with fewer fluctuations in blood glucose levels.

• Lower Hypoglycemia Risk: Unlike sulfonylureas, it does not trigger excess insulin release, thus reducing low blood sugar episodes.

Recommended Dosage

The typical dosage for GLIDAPAFLOZIN M 10/500 is:

• Once or twice daily, depending on medical advice.

• Taken with meals to enhance effectiveness and reduce gastrointestinal side effects.

• Swallowed whole with water—do not crush or chew.

• Dosage adjustments may be needed based on renal function, age, and glycemic control.

Possible Side Effects

While GLIDAPAFLOZIN M 10/500 is well-tolerated, some users may experience:

• Urinary Tract Infections (UTIs) due to increased glucose excretion.

• Increased Urination (Polyuria) – a common effect of SGLT2 inhibitors.

• Mild Gastrointestinal Discomfort such as nausea, bloating, or diarrhea (due to Metformin).

• Hypotension (Low Blood Pressure), especially in patients on antihypertensive medications.

• Lactic Acidosis (Rare but Serious) – Avoid in patients with kidney dysfunction.

• Genital Infections – Increased sugar excretion may promote yeast infections.

Precautions and Warnings

• Kidney Function: Not recommended for patients with severe renal impairment.

• Liver Disorders: Caution in patients with hepatic dysfunction.

• Heart Conditions: Patients with unstable cardiovascular disease should consult their doctor.

• Elderly Patients: Monitor closely for dehydration and hypotension.

• Pregnancy & Breastfeeding: Should be avoided unless prescribed by a healthcare provider.

Drug Interactions

GLIDAPAFLOZIN M 10/500 may interact with:

• Diuretics: May enhance dehydration risks.

• Insulin or Sulfonylureas: Increased risk of hypoglycemia.

• NSAIDs (Painkillers): May affect kidney function.

• Beta-Blockers: Can mask hypoglycemia symptoms.

Always inform your doctor about any other medications, supplements, or herbal remedies before starting GLIDAPAFLOZIN M 10/500.

Price & Availability

The price of GLIDAPAFLOZIN M 10/500 varies based on brand, manufacturer, and location. In India, the cost generally ranges between ₹400 to ₹900 per strip of 10 tablets. Prices may vary depending on discounts, generic versions, and bulk purchases.

Frequently Asked Questions (FAQs)

1. Can GLIDAPAFLOZIN M 10/500 be taken on an empty stomach?

• No, it should be taken with food to minimize gastrointestinal discomfort.

2. How long does it take to see results?

• Blood sugar levels start improving within a few weeks, with significant HbA1c reduction in 3-6 months.

3. Can this medication help in weight loss?

• Yes, Dapagliflozin promotes caloric loss, leading to gradual weight reduction.

4. What should I do if I miss a dose?

• Take it as soon as you remember, but if it’s close to the next dose, skip it—never double-dose.

5. Is long-term use of GLIDAPAFLOZIN M 10/500 safe?

• Yes, but regular kidney function, blood glucose, and cardiovascular monitoring are recommended.

6. Can I consume alcohol while taking this medication?

• Alcohol should be avoided, as it increases the risk of lactic acidosis and affects blood sugar control.

Conclusion

GLIDAPAFLOZIN M 10/500 (Dapagliflozin 10mg + Metformin SR 500mg) is a highly effective dual therapy for type 2 diabetes, offering superior glycemic control, weight management, and cardiovascular benefits. However, proper dosage adherence, lifestyle modifications, and regular health check-ups are essential to maximize its benefits while minimizing risks.

If you have diabetes or are at risk, consult your healthcare provider to determine if GLIDAPAFLOZIN M 10/500 is the right choice for your treatment plan.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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