Gliclazide 30 mg

Introduction

GLICLAGLAZE MR 30 is an oral antidiabetic medication that contains Gliclazide SR (30 mg) as its active ingredient. It belongs to the sulfonylurea class of drugs and is primarily prescribed to manage Type 2 Diabetes Mellitus (T2DM). Gliclazide helps regulate blood sugar levels by stimulating insulin secretion from the pancreas, making it an effective option for non-insulin-dependent diabetics.

This article provides an in-depth overview of GLICLAGLAZE MR 30, including its uses, dosage, benefits, side effects, precautions, price, and more.

Key Ingredients

• Gliclazide SR (30 mg): A second-generation sulfonylurea that enhances insulin secretion from pancreatic beta cells.

• Sustained Release (SR) Formulation: Ensures prolonged drug action for better glycemic control.

Uses of GLICLAGLAZE MR 30

GLICLAGLAZE MR 30 is prescribed to patients with Type 2 Diabetes Mellitus (T2DM) to:

• Maintain optimal blood glucose levels

• Reduce hyperglycemia-related complications

• Enhance insulin response in pancreatic beta cells

• Lower the risk of microvascular and macrovascular diabetic complications

How Does GLICLAGLAZE MR 30 Work?

Gliclazide, the active ingredient in GLICLAGLAZE MR 30, works through multiple mechanisms:

1. Stimulates Insulin Secretion: Acts on pancreatic beta cells to increase insulin production.

2. Enhances Insulin Sensitivity: Improves the body's ability to utilize insulin effectively.

3. Reduces Hepatic Glucose Production: Lowers glucose production by the liver, preventing spikes in blood sugar.

4. Protects Against Diabetic Complications: Exhibits antioxidant and anti-inflammatory properties to safeguard against diabetic retinopathy, nephropathy, and neuropathy.

Dosage and Administration

Recommended Dosage:

• Initial Dose: 30 mg (one tablet) once daily with breakfast.

• Maintenance Dose: Can be increased up to 120 mg per day, depending on blood glucose levels.

• Maximum Dose: Should not exceed 120 mg/day.

Administration Instructions:

• Take once daily preferably in the morning.

• Swallow the tablet whole with a glass of water.

• Do not crush or chew the tablet.

• Maintain a consistent time each day for better blood glucose control.

• Adhere to a balanced diet and exercise regimen.

Benefits of GLICLAGLAZE MR 30

• Prolonged Blood Sugar Control: The SR (Sustained Release) formulation ensures a steady and long-lasting effect.

• Lowers HbA1c Levels: Helps in maintaining stable glycemic control.

• Reduces Risk of Hypoglycemia: Compared to older sulfonylureas, Gliclazide SR has a lower risk of causing low blood sugar episodes.

• Cardiovascular Protection: Gliclazide has demonstrated protective effects on blood vessels.

• Improves Beta-Cell Function: Enhances insulin secretion efficiency.

Side Effects of GLICLAGLAZE MR 30

Although GLICLAGLAZE MR 30 is well tolerated, some users may experience mild to moderate side effects:

Common Side Effects:

• Hypoglycemia (low blood sugar) – dizziness, sweating, hunger

• Headache

• Nausea or vomiting

• Diarrhea or constipation

• Mild weight gain

Rare but Serious Side Effects:

• Severe hypoglycemia (if taken without food or excessive exercise)

• Allergic reactions – rash, itching, swelling

• Liver dysfunction – yellowing of the skin/eyes (jaundice)

• Blood disorders – low white blood cell count (leukopenia) or low platelet count (thrombocytopenia)

• Gastrointestinal upset – severe stomach pain or bleeding

Precautions and Warnings

Who Should Not Take GLICLAGLAZE MR 30?

• Patients with Type 1 Diabetes or Diabetic Ketoacidosis (DKA)

• Individuals with severe kidney or liver disease

• Pregnant or breastfeeding women (unless prescribed by a doctor)

• People with severe sulfonylurea allergies

Precautionary Measures:

• Monitor blood sugar regularly to prevent hypoglycemia.

• Avoid alcohol consumption, as it can cause fluctuations in glucose levels.

• Adjust dose carefully if used alongside insulin or other antidiabetic medications.

• Elderly patients should use caution to prevent hypoglycemia.

Drug Interactions

GLICLAGLAZE MR 30 may interact with certain medications, affecting its efficacy:

Drugs That Increase the Risk of Hypoglycemia:

• Beta-blockers (e.g., Propranolol, Atenolol)

• Fluoroquinolone antibiotics (e.g., Ciprofloxacin, Levofloxacin)

• NSAIDs (e.g., Ibuprofen, Aspirin)

Drugs That Decrease Gliclazide’s Effectiveness:

• Corticosteroids (e.g., Prednisone, Dexamethasone)

• Diuretics (e.g., Hydrochlorothiazide, Furosemide)

• Oral Contraceptives

Price and Availability

The cost of GLICLAGLAZE MR 30 varies depending on the brand and pharmacy. In India, the approximate price per strip (10 tablets) is ₹50 – ₹150. Prices may fluctuate based on location and pharmacy discounts.

Frequently Asked Questions (FAQs)

1. Can GLICLAGLAZE MR 30 be taken with Metformin?

Yes, Gliclazide SR is often prescribed in combination with Metformin for better glycemic control.

2. What happens if I miss a dose?

If you miss a dose, take it as soon as you remember. If it’s close to the next dose, skip the missed dose—do not double the dose.

3. Can I stop taking GLICLAGLAZE MR 30 suddenly?

No, stopping Gliclazide SR suddenly can cause severe blood sugar fluctuations. Consult your doctor before making any changes.

4. Is GLICLAGLAZE MR 30 safe for long-term use?

Yes, when used as directed by a physician, GLICLAGLAZE MR 30 is safe for long-term diabetes management.

5. Does GLICLAGLAZE MR 30 cause weight gain?

Gliclazide may cause mild weight gain, but maintaining a healthy diet and exercise routine can prevent excessive weight gain.

Conclusion

GLICLAGLAZE MR 30 (Gliclazide SR 30 mg) is an effective oral antidiabetic drug that helps in controlling Type 2 Diabetes Mellitus (T2DM). It provides sustained blood sugar regulation, reduces diabetes-related complications, and improves insulin efficiency. While generally safe, patients must adhere to prescribed dosages, maintain a healthy lifestyle, and monitor for any potential side effects.

If you are considering GLICLAGLAZE MR 30, consult your doctor or endocrinologist for personalized medical advice.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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