Dapagliflozin

Introduction

GLIDAPAFLOZIN 10 is a pharmaceutical formulation containing Dapagliflozin (10mg), a potent oral antidiabetic drug. Dapagliflozin belongs to the SGLT2 inhibitor class, designed to manage Type 2 Diabetes Mellitus (T2DM) by enhancing glucose excretion through urine. It is an effective treatment for blood sugar control and is often prescribed as monotherapy or in combination with other antidiabetic medications.

What is Dapagliflozin?

Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by preventing glucose reabsorption in the kidneys, allowing excess sugar to be excreted in the urine. This process not only helps in lowering blood glucose levels but also contributes to weight loss and improved cardiovascular health.

Key Benefits of GLIDAPAFLOZIN 10

1. Effective Blood Sugar Control – Helps lower and maintain optimal glucose levels.

2. Weight Management – Assists in weight loss by eliminating excess glucose through urine.

3. Cardiovascular Protection – Reduces the risk of heart failure and related complications.

4. Kidney Function Support – Provides renal protective benefits for diabetic patients.

5. Reduction in Blood Pressure – Lowers systolic blood pressure as an added benefit.

How Does GLIDAPAFLOZIN 10 Work?

GLIDAPAFLOZIN 10 functions by inhibiting SGLT2 receptors in the kidney’s proximal tubules, thereby reducing glucose reabsorption. This mechanism leads to:

• Increased urinary glucose excretion (UGE)

• Reduced plasma glucose concentration

• Lower insulin resistance

• Enhanced glycemic control

By working independently of insulin pathways, Dapagliflozin 10mg is beneficial for patients with insulin resistance or those requiring an add-on therapy to existing medications like Metformin, Sulfonylureas, or DPP-4 inhibitors.

Indications – Who Can Use GLIDAPAFLOZIN 10?

Dapagliflozin (10mg) is primarily prescribed for:

• Type 2 Diabetes Mellitus (T2DM) – As monotherapy or in combination with other drugs.

• Heart Failure – Beneficial for individuals with heart failure with reduced ejection fraction (HFrEF).

• Chronic Kidney Disease (CKD) – Helps slow kidney function decline in diabetic and non-diabetic patients.

Dosage and Administration

Recommended Dosage:

• Standard Dose: 10mg once daily

• With or Without Food: Can be taken at any time of the day, preferably at the same time daily.

• Renal Impairment: Not recommended in patients with severe renal impairment (eGFR <25 mL/min/1.73m²).

Missed Dose:

• If a dose is missed, take it as soon as remembered.

• If close to the next scheduled dose, skip the missed dose—do not double dose.

Side Effects of GLIDAPAFLOZIN 10

While GLIDAPAFLOZIN 10 is generally well tolerated, some individuals may experience:

Common Side Effects:

• Urinary tract infections (UTIs)

• Increased urination

• Thirst and dehydration

• Mild dizziness

• Fatigue

Serious Side Effects (Rare Cases):

• Ketoacidosis – Symptoms include nausea, vomiting, abdominal pain, and difficulty breathing.

• Severe hypoglycemia – If combined with insulin or sulfonylureas.

• Genital yeast infections – More common in females.

• Kidney function decline – Requires monitoring in at-risk individuals.

Drug Interactions

Medications That May Interact with GLIDAPAFLOZIN 10:

1. Diuretics – May enhance dehydration risk.

2. Insulin and Sulfonylureas – Increased hypoglycemia risk.

3. Rifampin – May reduce Dapagliflozin effectiveness.

4. ACE Inhibitors & ARBs – Can impact kidney function.

Warnings and Precautions

• Not for Type 1 Diabetes or Diabetic Ketoacidosis (DKA).

• Monitor kidney function regularly in patients with kidney disease.

• Not recommended during pregnancy and breastfeeding.

• Stay hydrated to avoid dehydration and hypotension.

• Inform your doctor if you have frequent UTIs or genital infections.

Price and Availability in India

The Dapagliflozin 10mg price varies depending on the manufacturer and region in India. On average:

• Per Strip (10 Tablets): ₹300 – ₹500

• Monthly Supply (30 Tablets): ₹900 – ₹1500

FAQs About GLIDAPAFLOZIN 10

1. Can GLIDAPAFLOZIN 10 be taken on an empty stomach?

Yes, it can be taken with or without food.

2. Is GLIDAPAFLOZIN 10 safe for elderly patients?

Yes, but kidney function should be monitored closely.

3. Can Dapagliflozin cause dehydration?

Yes, it increases urine output, so staying hydrated is essential.

4. Can GLIDAPAFLOZIN 10 be used for weight loss?

While not a weight-loss medication, it may aid in reducing body weight.

5. How long does it take for Dapagliflozin to show results?

Significant improvements in blood sugar levels may be seen within 2-4 weeks.

Conclusion

GLIDAPAFLOZIN 10 (Dapagliflozin 10mg) is a highly effective SGLT2 inhibitor that provides blood sugar control, weight management, cardiovascular protection, and kidney health benefits. It is a valuable treatment option for individuals with Type 2 Diabetes Mellitus, particularly those who require an insulin-independent mechanism of action. Patients must follow dosage guidelines, monitor their kidney function, and stay well-hydrated to avoid potential side effects. Always consult your doctor before starting or adjusting any diabetes medication regimen.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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