Dapagliflozin and metformin Sustained Release Tablets

Introduction

GLIDAPAFLOZIN M 5/500 is a combination medication that contains Dapagliflozin (5mg) and Metformin (500mg). It is widely prescribed for the management of Type 2 Diabetes Mellitus (T2DM) in adults who require improved glycemic control. By combining two powerful antidiabetic agents, Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitor and Biguanide, this formulation effectively reduces blood sugar levels, enhances insulin sensitivity, and promotes better glucose utilization in the body.

Key Ingredients

1. Dapagliflozin (5mg) – An SGLT2 inhibitor that promotes glucose excretion through urine, thereby lowering blood sugar levels.

2. Metformin (500mg) – A biguanide that reduces hepatic glucose production and enhances insulin sensitivity in muscle cells.

How Does GLIDAPAFLOZIN M 5/500 Work?

The combination of Dapagliflozin and Metformin works through complementary mechanisms:

• Dapagliflozin: Blocks the reabsorption of glucose by the kidneys, facilitating its excretion through urine.

• Metformin: Reduces glucose production in the liver and increases peripheral insulin sensitivity, thereby enhancing glucose uptake by muscle cells.

Together, they help in maintaining stable blood glucose levels, reducing the risk of diabetes-related complications.

Uses of GLIDAPAFLOZIN M 5/500

GLIDAPAFLOZIN M 5/500 is primarily used for:

• Managing Type 2 Diabetes Mellitus when diet and exercise alone are insufficient.

• Lowering HbA1c levels to reduce long-term diabetic complications.

• Supporting weight management in diabetic patients due to glucose excretion benefits.

• Potentially improving cardiovascular health in diabetes patients with heart conditions.

Dosage and Administration

• The recommended starting dose is one tablet once or twice daily, as per a doctor’s prescription.

• It should be taken with meals to minimize gastrointestinal side effects.

• Dosage adjustments may be required based on kidney function and blood sugar levels.

Precautions and Warnings

• Kidney Function: Dapagliflozin may not be suitable for patients with severe kidney impairment.

• Lactic Acidosis: Metformin can increase the risk of lactic acidosis in certain individuals.

• Dehydration: Patients should ensure adequate fluid intake to prevent dehydration.

• Urinary Tract Infections (UTIs): Dapagliflozin increases glucose excretion in urine, potentially leading to UTIs.

• Hypoglycemia Risk: While the combination does not directly cause hypoglycemia, caution is advised if used with insulin or sulfonylureas.

Potential Side Effects

Some common and rare side effects associated with GLIDAPAFLOZIN M 5/500 include:

Common Side Effects:

• Nausea

• Diarrhea

• Frequent urination

• Mild dehydration

• Low blood pressure (Hypotension)

• Genital yeast infections

Rare but Serious Side Effects:

• Lactic Acidosis (from Metformin) – Symptoms include muscle pain, weakness, difficulty breathing.

• Ketoacidosis (from Dapagliflozin) – Can cause nausea, vomiting, stomach pain, and confusion.

• Severe Urinary Infections – May present with fever, pain, or burning sensation during urination.

• Allergic Reactions – Skin rashes, itching, or swelling.

Drug Interactions

Certain medications may interact with GLIDAPAFLOZIN M 5/500, such as:

• Diuretics – May enhance the risk of dehydration.

• Insulin or Sulfonylureas – May increase the risk of hypoglycemia.

• NSAIDs & ACE Inhibitors – Can affect kidney function when combined with Dapagliflozin.

• Alcohol – Should be avoided to minimize the risk of lactic acidosis from Metformin.

Benefits of GLIDAPAFLOZIN M 5/500

• Improved Glycemic Control – Effectively lowers fasting and postprandial glucose levels.

• Weight Loss Benefits – Helps in weight reduction due to glucose excretion.

• Heart & Kidney Protection – May reduce cardiovascular and renal complications in diabetic patients.

• Minimal Risk of Hypoglycemia – Unlike sulfonylureas or insulin, this combination has a lower risk of low blood sugar.

Who Should Not Take GLIDAPAFLOZIN M 5/500?

• Patients with Type 1 Diabetes or Diabetic Ketoacidosis (DKA).

• Individuals with severe kidney disease or liver dysfunction.

• Pregnant or breastfeeding women (unless advised by a doctor).

• Those with a history of lactic acidosis.

Lifestyle and Dietary Recommendations

To maximize the benefits of GLIDAPAFLOZIN M 5/500, consider the following lifestyle changes:

• Eat a Balanced Diet – Focus on whole grains, lean proteins, and fiber-rich vegetables.

• Exercise Regularly – Engage in at least 30 minutes of moderate exercise daily.

• Stay Hydrated – Drink plenty of fluids to prevent dehydration and urinary infections.

• Monitor Blood Sugar Levels – Regular glucose monitoring can help in dose adjustments.

Price and Availability in India

The price of GLIDAPAFLOZIN M 5/500 may vary depending on the brand and location. On average, a strip of 10 tablets costs around INR 250-400. It is available at leading pharmacies and online medical stores.

Conclusion

GLIDAPAFLOZIN M 5/500 (Dapagliflozin 5mg + Metformin 500mg) is a highly effective antidiabetic medication that helps in controlling blood sugar levels while offering additional benefits like weight management and cardiovascular protection. It is well-tolerated by most patients, but proper monitoring and adherence to a doctor’s advice are essential to avoid complications.

Always consult a healthcare professional before starting or modifying your diabetes treatment regimen.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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