Methotrexate 15mg Tablets – Uses, Dosage, Side Effects & Warnings

Introduction to Methotrexate 15mg

METROTREX 15 is a well-known medication containing Methotrexate (15mg), widely used for treating various autoimmune disorders, certain types of cancer, and inflammatory conditions. Methotrexate is classified as a disease-modifying antirheumatic drug (DMARD) and an antimetabolite, effectively managing conditions such as rheumatoid arthritis, psoriasis, and specific cancers.

This article explores the uses, benefits, dosage, side effects, precautions, and pricing of METROTREX 15, providing essential insights for patients and healthcare providers.

Key Ingredients

The primary active ingredient in METROTREX 15 is Methotrexate (15mg), which works by inhibiting dihydrofolate reductase, a crucial enzyme in DNA synthesis, ultimately preventing abnormal cell growth and reducing immune system overactivity.

Uses of METROTREX 15 (Methotrexate 15mg)

1. Rheumatoid Arthritis

METROTREX 15 is widely prescribed to patients suffering from rheumatoid arthritis (RA) to reduce inflammation, joint pain, and damage. It helps slow disease progression and improves joint mobility.

2. Psoriasis and Psoriatic Arthritis

This medication is effective in treating psoriasis, a chronic skin condition characterized by rapid skin cell growth, leading to scaling and inflammation. It also benefits patients with psoriatic arthritis, reducing joint pain and swelling.

3. Cancer Treatment

METROTREX 15 plays a significant role in chemotherapy for cancers such as leukemia, breast cancer, lung cancer, and lymphoma. It interferes with cancer cell replication, slowing down tumor growth.

4. Ectopic Pregnancy

In cases of ectopic pregnancy, where the fertilized egg implants outside the uterus, Methotrexate (15mg) is used to dissolve the pregnancy without requiring surgery.

5. Inflammatory Bowel Disease (IBD)

Conditions like Crohn’s disease and ulcerative colitis benefit from METROTREX 15, as it reduces inflammation and helps maintain remission.

How METROTREX 15 Works

Methotrexate (15mg) works by interfering with folic acid metabolism, inhibiting dihydrofolate reductase, an enzyme essential for DNA and RNA synthesis. This suppression leads to reduced cell proliferation, which is beneficial in autoimmune conditions and cancer therapy.

Dosage and Administration

General Dosage Guidelines

• For rheumatoid arthritis and psoriasis: Typically, 15mg once a week.

• For cancer treatment: Dosage varies based on cancer type and stage; administered under medical supervision.

• For ectopic pregnancy: A single intramuscular injection or multiple doses as prescribed.

Important Dosage Instructions

• Always take METROTREX 15 as directed by a healthcare provider.

• Take with plenty of water to avoid gastrointestinal side effects.

• Do not exceed the prescribed dose, as Methotrexate toxicity can be life-threatening.

Side Effects of METROTREX 15

Like all medications, Methotrexate (15mg) may cause side effects. Common and serious side effects include:

Common Side Effects

• Nausea and vomiting

• Fatigue and dizziness

• Loss of appetite

• Mouth ulcers

• Mild hair loss

Serious Side Effects

• Liver toxicity (hepatotoxicity)

• Bone marrow suppression (low blood cell counts)

• Severe lung infections and fibrosis

• Kidney impairment

• Gastrointestinal bleeding

• Increased risk of infections

If any severe symptoms appear, seek immediate medical attention.

Precautions and Warnings

Who Should Avoid METROTREX 15?

• Pregnant and breastfeeding women (Methotrexate is highly teratogenic)

• Patients with severe liver or kidney disease

• Individuals with active infections

• Alcohol consumers (Methotrexate increases liver toxicity)

Drug Interactions

METROTREX 15 interacts with several medications, including:

• NSAIDs (e.g., Ibuprofen, Aspirin) – Can increase toxicity.

• Antibiotics (e.g., Trimethoprim, Sulfonamides) – May cause blood disorders.

• Proton Pump Inhibitors (e.g., Omeprazole) – Reduces Methotrexate clearance.

Consult a doctor before combining METROTREX 15 with other drugs.

Benefits of METROTREX 15

• Highly effective in autoimmune diseases

• Slows disease progression in RA and psoriasis

• Essential in chemotherapy for various cancers

• Non-invasive alternative to surgery for ectopic pregnancy

• Well-researched and widely used globally

Price of METROTREX 15 in India

The price of Methotrexate (15mg) varies depending on the pharmacy and location. On average, the cost ranges between ₹150-₹500 per strip of 10 tablets. Prices may vary based on discounts and availability.

FAQs

1. Can I take METROTREX 15 daily?

No, Methotrexate (15mg) is usually taken once a week. Daily use can cause serious toxicity.

2. How long does it take for METROTREX 15 to work?

For rheumatoid arthritis and psoriasis, it may take 4-6 weeks to see improvements. For cancer treatment, the effects depend on the individual’s condition and dosage regimen.

3. Can I drink alcohol while taking METROTREX 15?

No, alcohol increases the risk of liver damage when combined with Methotrexate.

4. What should I do if I miss a dose?

Take the missed dose as soon as possible. However, do not double dose to make up for a missed one.

5. Is METROTREX 15 safe during pregnancy?

No, Methotrexate is strictly contraindicated during pregnancy and breastfeeding due to severe birth defects and toxicity.

Conclusion

METROTREX 15 (Methotrexate 15mg) is a potent and essential medication for managing autoimmune diseases, psoriasis, rheumatoid arthritis, cancer, and ectopic pregnancy. While highly effective, it requires strict medical supervision due to potential side effects and interactions. Patients must follow dosage guidelines, avoid alcohol, and consult their doctor regarding any concerns.

If prescribed METROTREX 15, ensure regular medical checkups to monitor liver function, kidney health, and blood counts to prevent complications. Always seek medical advice before starting or stopping this medication.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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