The Power of Empagliflozin (12.5mg) and Metformin Hydrochloride (1000mg) in Diabetes Management

Introduction

GLIEMPAFLOZIN MET 12.5mg/1000mg is a highly effective oral medication used for the management of type 2 diabetes mellitus. It combines two potent antidiabetic agents: Empagliflozin (12.5mg) and Metformin Hydrochloride (1000mg). This combination helps regulate blood glucose levels by enhancing insulin sensitivity, reducing glucose production, and promoting glucose excretion via urine. It is widely recommended for individuals struggling with high blood sugar levels despite lifestyle modifications.

Key Ingredients

Empagliflozin (12.5mg)

Empagliflozin belongs to the Sodium-Glucose Co-Transporter-2 (SGLT2) inhibitor class. It works by inhibiting SGLT2 proteins in the kidneys, thereby reducing glucose reabsorption and increasing glucose excretion through urine. This mechanism significantly lowers blood sugar levels and also aids in weight management.

Metformin Hydrochloride (1000mg)

Metformin is a first-line treatment for type 2 diabetes and falls under the biguanide class of drugs. It primarily acts by decreasing hepatic glucose production, improving insulin sensitivity, and enhancing peripheral glucose uptake. Unlike some other diabetes medications, Metformin Hydrochloride (1000mg) does not cause hypoglycemia when used alone.

Key Benefits of GLIEMPAFLOZIN MET 12.5mg/1000mg

• Effective Blood Sugar Control: The dual mechanism helps lower both fasting and postprandial glucose levels.

• Weight Management: Empagliflozin (12.5mg) promotes weight loss by eliminating excess glucose via urine.

• Cardiovascular Benefits: Studies suggest that Empagliflozin reduces the risk of cardiovascular events in diabetic patients.

• Improved Insulin Sensitivity: Metformin Hydrochloride (1000mg) enhances insulin efficiency, helping the body utilize glucose better.

• Kidney Protection: Empagliflozin has been shown to provide renal benefits, reducing the risk of diabetic kidney disease.

• Lower Risk of Hypoglycemia: Unlike sulfonylureas, this combination minimizes the risk of dangerously low blood sugar levels.

How Does GLIEMPAFLOZIN MET 12.5mg/1000mg Work?

The combination of Empagliflozin (12.5mg) and Metformin Hydrochloride (1000mg) ensures a dual-action approach:

1. Empagliflozin blocks SGLT2 transporters in the kidneys, leading to increased urinary glucose excretion.

2. Metformin decreases glucose production in the liver while improving insulin sensitivity, reducing blood sugar levels effectively.

Dosage & Administration

• The typical dosage of Empagliflozin (12.5mg) and Metformin Hydrochloride (1000mg) is one tablet daily, preferably with meals to reduce gastrointestinal side effects.

• Always follow your healthcare provider’s prescription and do not self-adjust the dosage.

• Adequate hydration is recommended to prevent dehydration due to increased urination caused by Empagliflozin (12.5mg).

Side Effects

While GLIEMPAFLOZIN MET 12.5mg/1000mg is generally well-tolerated, some individuals may experience:

• Urinary tract infections (UTIs)

• Increased urination due to glucose excretion

• Mild gastrointestinal discomfort (bloating, nausea, diarrhea)

• Hypotension (low blood pressure) in some cases

• Vitamin B12 deficiency (long-term use of Metformin)

• Lactic acidosis (very rare but serious side effect of Metformin)

Precautions & Warnings

• Not suitable for type 1 diabetes or diabetic ketoacidosis.

• Individuals with severe kidney impairment should avoid using Empagliflozin (12.5mg).

• Metformin Hydrochloride (1000mg) may increase the risk of lactic acidosis in individuals with kidney or liver disease.

• Avoid alcohol consumption while taking this medication.

• Monitor kidney function regularly, as Empagliflozin is excreted through the kidneys.

• Consult your doctor if you experience severe dehydration or persistent infections.

Who Should Take GLIEMPAFLOZIN MET 12.5mg/1000mg?

• Patients with type 2 diabetes who have uncontrolled blood sugar levels despite lifestyle changes.

• Individuals requiring a dual-action therapy for optimal glycemic control.

• Patients who need a diabetes medication with cardiovascular and renal protection benefits.

Who Should Avoid GLIEMPAFLOZIN MET 12.5mg/1000mg?

• Those with severe kidney or liver disease.

• Individuals with severe dehydration or hypotension.

• Patients with chronic urinary tract infections.

• Pregnant or breastfeeding women should consult a doctor before use.

Drug Interactions

• Diuretics: Increased risk of dehydration and low blood pressure.

• Insulin or sulfonylureas: May cause hypoglycemia.

• NSAIDs and ACE inhibitors: Can affect kidney function.

• Alcohol: Increases the risk of lactic acidosis with Metformin Hydrochloride (1000mg).

Storage Instructions

• Store at room temperature (25°C) in a dry place.

• Keep away from direct sunlight and moisture.

• Keep out of reach of children.

Price of GLIEMPAFLOZIN MET 12.5mg/1000mg in India

The price of Empagliflozin (12.5mg) and Metformin Hydrochloride (1000mg) varies based on brand and location. On average, it costs INR 400-800 per strip of 10 tablets. Prices may vary depending on pharmacy discounts and availability.

Conclusion

GLIEMPAFLOZIN MET 12.5mg/1000mg is a powerful anti-diabetic medication that effectively lowers blood sugar levels while offering weight management, cardiovascular, and kidney benefits. The combination of Empagliflozin (12.5mg) and Metformin Hydrochloride (1000mg) makes it an ideal choice for individuals struggling with type 2 diabetes. However, proper medical supervision is necessary to minimize risks and optimize treatment outcomes. Always consult your healthcare provider before starting this medication.

For more information, consult your diabetologist or pharmacist today!

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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